Nitrogen removal performance and microbial community characteristics of a submerged macrophyte pond–constructed wetland composite system

Journal of Water Process Engineering, Год журнала: 2025, Номер 72, С. 107492 - 107492

Опубликована: Март 20, 2025

Язык: Английский

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Residues of 6PPD-Q in the Aquatic Environment and Toxicity to Aquatic Organisms: A Review

Fishes, Год журнала: 2025, Номер 10(4), С. 146 - 146

Опубликована: Март 25, 2025

N-(1,3-dimethylbutyl)-N’-phenyl-p-benzoquinone (6PPD-Q) is an emerging environmental contaminant that widely distributed in aquatic environments and presents significant toxicological risks to organisms. As 6PPD-Q primarily derived from oxidative transformation of the tire antioxidant N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD), its persistence potential for bioaccumulation organisms have raised widespread concerns. This study reviews sources, spatial distribution, migration, behaviors 6PPD-Q, as well degradation mechanisms different media. Additionally, this review systematically explores effects on organisms, including physiological, biochemical, molecular impacts fish, crustaceans, mollusks, algae, with a focus mechanisms. Finally, we discuss limitations current research propose key directions future studies, long-term ecological risk assessments, bioaccumulation, metabolic pathway analysis, optimization pollution control strategies, aiming provide scientific basis assessment management 6PPD-Q.

Язык: Английский

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Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

6PPDQ, a rubber tire-derived environmental pollutant, exhibits significant hepatotoxicity. However, its hepatotoxic mechanisms remain insufficiently studied and systematically evaluated. This study integrated network toxicology, transcriptomics, metabolomics to investigate toxicity mechanisms. ADMETlab 3.0 was used predict physicochemical properties multiorgan toxicity. The targets related 6PPDQ liver injury were obtained from public databases, protein-protein interaction (PPI) constructed identify key targets. Meanwhile, molecular docking performed assess 6PPDQ's binding affinity core proteins. Transcriptomics differential gene expression analysis on the livers of Kunming mice exposed 4 mg/kg explore transcriptomic alterations, while metabolomic profiling identified disrupted metabolic pathways. Network toxicology results reveal that primarily induces hepatotoxicity through apoptosis, inflammation, lipid disturbances. Key targets, including P53, Mapk1, Mapk14, Casp8, Traf6, Ripk1, Tnf, are identified, with strong affinities suggesting direct interactions. Transcriptomic analyses further confirms disruptions in TNF, NF-kappa B, oxidative phosphorylation, autophagy pathways, glycerolipid metabolism. Overall, this provides comprehensive mechanistic framework for 6PPDQ-induced new perspective subsequent studies mechanism

Язык: Английский

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Phytotoxic effects of 6PPD on wheat: Insights into germination inhibition, oxidative stress, and metabolic disruptions

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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