PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties

European journal of ecology, biology and agriculture., Год журнала: 2025, Номер 2(2), С. 30 - 46

Опубликована: Март 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Язык: Английский

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A machine learning multimodal profiling of per- and Polyfluoroalkyls (PFAS) distribution across animal species organs via clustering and dimensionality reduction techniques

Food Research International, Год журнала: 2025, Номер 211, С. 116463 - 116463

Опубликована: Апрель 19, 2025

Язык: Английский

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Unveiling PFAS hazard in European surface waters using an interpretable machine-learning model

Environment International, Год журнала: 2025, Номер 199, С. 109504 - 109504

Опубликована: Май 1, 2025

Язык: Английский

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Hair analysis as a non-invasive method for assessing the exposure of wildlife to per- and poly-fluoroalkyl substances (PFAS)

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126443 - 126443

Опубликована: Май 1, 2025

Язык: Английский

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