
Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17
Опубликована: Апрель 9, 2025
Long-term adherence to the Mediterranean Diet has been shown improve cognitive function in patients. However, there is a lack of evidence regarding impact diet and impairment on long-term mortality outcomes. This study aims explore whether an interaction between degree The included 2,520 participants from National Health Nutrition Examination Survey (NHANES) conducted 2011 2014. was assessed using 9-point alternative index (aMED index). Cognitive Consortium Establish Registry for Alzheimer's disease (CERAD), Animal Fluency Test (AFT), Digital Symbol Substitution (DSST). By accessing public records Death Index (NDI), NHANES participants' information linked death certificate determine causes during follow-up period, up December 31, 2019, with specified according ICD-10. Participants were categorized based median aMED score into low (scores 0-3), moderate (score 4), high 5-9) groups. by calculating arithmetic mean standardized scores (Z-scores) each test. below first quartile considered have impairment. Cox proportional hazards regression models used assess relationship impairment, aMED, all-cause cardiovascular Additionally, these outcomes evaluated. participants, 481 deaths which 129 (26.8%) cardiovascular-related. population 4, 632 individuals (25.1%) A higher associated reduced risk cardiovascular-related (HR, 0.65; 95% CI, 0.52-0.81, p < 0.001; HR, 0.73; 0.47-0.91, = 0.039). increased 1.78; 1.46-2.18, 1.80; 1.22-2.64, 0.003). Individuals both lower had risks mortality. Subgroup analysis indicates that only subgroup There increasing (p 0.028). concerning mortality, but not Among more significant
Язык: Английский