Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 270 - 270
Опубликована: Фев. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Язык: Английский
Metabolic Syndrome and Schizophrenia: Adding a Piece to the Interplay Between the Kynurenine Pathway and Inflammation
Metabolites,
Год журнала:
2025,
Номер
15(3), С. 176 - 176
Опубликована: Март 5, 2025
The
biology
of
schizophrenia
is
highly
complex
and
multifaceted.
Numerous
efforts
have
been
made
over
the
years
to
disentangle
heterogeneity
disease,
gradually
leading
a
more
detailed
understanding
its
underlying
pathogenic
mechanisms.
Two
cardinal
elements
in
pathophysiology
are
neuroinflammation
alterations
neurotransmission.
kynurenine
(KYN)
pathway
(KP)
particular
importance
because
it
inducted
by
systemic
low-grade
inflammation
peripheral
tissues,
producing
metabolites
that
neuroactive
(i.e.,
modulating
glutamatergic
cholinergic
neurotransmission),
neuroprotective,
or
neurotoxic.
Consequently,
KP
at
crossroads
between
two
primary
systems
involved
pathogenesis
schizophrenia.
It
bridges
central
nervous
system
(CNS)
periphery,
as
can
cross
blood–brain
barrier
modulate
neuronal
activity.
Metabolic
syndrome
plays
crucial
role
this
context,
frequently
co-occurs
with
schizophrenia,
contributing
sub-inflammatory
state
able
activate
KP.
This
narrative
review
provides
valuable
insights
into
these
interactions,
offering
framework
for
developing
targeted
therapeutic
interventions
precision
psychiatry
approaches
disorder.
Язык: Английский
Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction
Neurotoxicity Research,
Год журнала:
2025,
Номер
43(2)
Опубликована: Март 28, 2025
Язык: Английский
Developing a risk assessment model for treatment-resistant schizophrenia: The role of niacin receptor GPR109A and prostaglandin receptors DP1, EP2, and EP4 in the niacin-induced flushing pathway
Schizophrenia Research,
Год журнала:
2025,
Номер
280, С. 30 - 38
Опубликована: Апрель 11, 2025
Язык: Английский
A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia
Huan Yu,
Rui Li,
Xue‐jun Liang
и другие.
BMC Psychiatry,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 20, 2024
Major
depressive
disorder
(MDD)
and
schizophrenia
(SCH)
are
common
severe
mental
disorders
that
mainly
diagnosed
depending
on
the
subjective
identification
by
psychiatrists.
Finding
potential
objective
biomarkers
can
distinguish
these
two
diseases
is
still
meaningful.
In
present
study,
we
investigate
differences
in
plasma
inflammatory
cytokines
short-chain
fatty
acids
(SCFAs)
among
patients
with
MDD
(n
=
24)
SCH
24),
gender-
age-matched
healthy
controls
(HC,
n
27)
identify
biomarkers.
We
found
concentrations
of
pro-inflammatory
were
increased,
whereas
anti-inflammatory
decreased
both
SCH.
Meanwhile,
except
for
an
increase
4-Methylvaleric
acid,
other
SCFAs
statistical
reduced
Moreover,
biomarker
panels
developed
effectively
discriminate
from
HC
(AUC
0.997),
0.999),
each
(MDD
SCH,
AUC
0.983).
These
data
suggest
alterations
might
be
one
features
distinguishing
Chinese
Clinical
Trial
Registry:
ChiCTR2100051243,
registration
date:
2021/09/16.
Язык: Английский
Cognitive rehabilitation in schizophrenia research: a bibliometric and visualization analysis
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 11, 2024
Objective
Cognitive
impairment
is
notably
prevalent
among
schizophrenic
individuals
and
acknowledged
as
one
of
the
core
features
disorder.
Despite
proliferation
literature
on
cognitive
rehabilitation
treatments
for
schizophrenia
in
recent
years,
there
remains
a
dearth
systematic
reviews
selections
research
this
area.
From
bibliometric
perspective,
study
aims
to
analyze
discuss
current
state,
developmental
trends,
potential
hotspots
over
past
two
decades.
Methods
The
Core
database
Web
Science
was
utilized
retrieve
articles
Schizophrenia
that
were
published
from
2004
2024.
Bibliometrics
applied
perform
both
quantitative
qualitative
analyses
authors,
institutions,
countries,
journals,
references,
keywords,
leveraging
tools
such
CiteSpace,
VOSviewer,
R
software
package
Bibliometrix.
Results
A
total
2,413
encompassed
study,
comprising
1,774
regular
373
review
articles.
United
States
emerged
country
with
highest
productivity
citation
counts,
engaging
academic
collaborations
40
nations.
This
followed
by
Kingdom
Spain.
King’s
College
London
stood
out
leading
institution
field.
However,
article
average
rate
authored
Susan
R.
McGurk
Dartmouth
Centre
Psychiatric
Research
States.
proved
be
most
influential
journal
domain,
its
being
cited
10,000
times.
Conclusion
provides
comprehensive
achievements
spanning
2024,
outlines
global
trends
future
projections.
Currently,
methods
neural
plasticity
brain
represent
cutting-edge
research.
safety,
efficacy,
standardization
virtual
reality
are
poised
emerge
Additionally,
neurobiological
foundations
remediation
therapy
constitute
an
unexplored
territory
ripe
further
investigation.
Язык: Английский