Molecules,
Год журнала:
2024,
Номер
30(1), С. 51 - 51
Опубликована: Дек. 26, 2024
In
recent
years,
there
has
been
growing
interest
in
the
development
of
greener
alternatives
to
traditional
reagents
used
carbon–carbon
coupling
reactions,
particularly
response
environmental
concerns.
The
commonly
aryl
halides,
despite
being
highly
reactive
Suzuki–Miyaura
(SMC),
pose
significant
risks.
As
a
result,
research
shifted
towards
exploring
use
phenols,
which
are
widely
accessible
and
environmentally
benign.
However,
phenols
considerably
less
due
poor
leaving
group
properties
hydroxyl
group,
necessitating
prior
activation
facilitate
their
reactions.
This
work
aims
review
investigations
on
strategies
for
focusing
application
related
C-C
couplings.
addition,
exploration
potential
conducting
step
“in
situ”
will
also
be
discussed.
We
hope
that
this
article
pave
way
more
sustainable
efficient
methodologies,
addressing
both
ecological
practical
challenges
organic
synthesis.
Antioxidants,
Год журнала:
2024,
Номер
13(10), С. 1198 - 1198
Опубликована: Окт. 3, 2024
A
series
of
16
(hetero)aryl
compounds
based
on
coumarin
and
equol
has
been
efficiently
synthesized
by
exploring
the
palladium-catalyzed
Suzuki
cross-coupling
reactions.
Polyphenol
(4-methyl-7-hydroxy
coumarin)
was
initially
converted
to
corresponding
imidazylate
then
subjected
coupling
reaction
with
4-methoxyphenylboronic
acid
obtain
coupled
product.
This
modified
approach
later
developed
into
a
one-pot
methodology
directly
reacting
polyphenol
1,1-sulfonyldiimidazole
(SDI)
boronic
in
situ
product
one
step.
Moreover,
an
array
(poly)phenols
were
diverse
this
optimized
step-economic
protocol.
The
screening
their
potential
antioxidant
activities
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
assay.
In
our
investigation,
Molecules,
Год журнала:
2024,
Номер
30(1), С. 51 - 51
Опубликована: Дек. 26, 2024
In
recent
years,
there
has
been
growing
interest
in
the
development
of
greener
alternatives
to
traditional
reagents
used
carbon–carbon
coupling
reactions,
particularly
response
environmental
concerns.
The
commonly
aryl
halides,
despite
being
highly
reactive
Suzuki–Miyaura
(SMC),
pose
significant
risks.
As
a
result,
research
shifted
towards
exploring
use
phenols,
which
are
widely
accessible
and
environmentally
benign.
However,
phenols
considerably
less
due
poor
leaving
group
properties
hydroxyl
group,
necessitating
prior
activation
facilitate
their
reactions.
This
work
aims
review
investigations
on
strategies
for
focusing
application
related
C-C
couplings.
addition,
exploration
potential
conducting
step
“in
situ”
will
also
be
discussed.
We
hope
that
this
article
pave
way
more
sustainable
efficient
methodologies,
addressing
both
ecological
practical
challenges
organic
synthesis.
