Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12155 - 12155
Опубликована: Ноя. 12, 2024
The
interplay
between
functional
food
nutrients
and
neurosteroids
has
garnered
significant
attention
for
its
potential
to
enhance
stress
resilience
in
health
and/or
disease.
Several
bioactive
nutrients,
including
medicinal
herbs,
flavonoids,
bioavailable
polyphenol-combined
nanoparticles,
as
well
probiotics,
vitamin
D
omega-3
fatty
acids,
have
been
shown
improve
blood-brain
barrier
(BBB)
dysfunction,
endogenous
neurosteroid
homeostasis
brain
function.
These
can
inhibit
oxidative
neuroinflammation,
which
are
linked
the
pathogenesis
of
various
neurological
disorders.
Interestingly,
flavonoids
exhibit
dose-dependent
effects,
activating
nuclear
factor
erythroid
2-related
2
(Nrf2)
pathway
at
physiological/low
dose
(neurohormesis).
This
leads
upregulation
antioxidant
phase
II
genes
proteins
such
heme
oxygenase-1
(HO-1)
sirtuin-1
(Sirt1),
activated
by
curcumin
resveratrol,
respectively.
adaptive
neuronal
response
mechanisms
help
protect
against
reactive
oxygen
species
(ROS)
neurotoxicity.
Impaired
Nrf2
hormone
signaling
exacerbate
selective
vulnerability
neuroinflammatory
conditions,
contributing
onset
progression
neurodegenerative
psychiatric
disorders,
Alzheimer's
disease,
anxiety
depression
other
due
neurons
stress.
review
focuses
on
targeting
redox
regulate
BBB
damage
associated
with
altered
GABAergic
neurotransmission.
By
exploring
underlying
molecular
using
innovative
technologies,
we
aim
develop
promising
neuroprotective
strategies
personalized
nutritional
neuroregenerative
therapies
prevent
or
attenuate
ultimately
promoting
health.
Язык: Английский
The use of induced pluripotent stem cells as a platform for the study of depression
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 9, 2024
The
neurobiological
mechanisms
underlying
major
depressive
disorder
(MDD)
remain
largely
unexplored
due
to
the
limited
availability
of
study
models
in
humans.
Induced
pluripotent
stem
cells
(iPSCs)
have
overcome
multiple
limitations
retrospective
clinical
studies,
contributing
a
more
detailed
understanding
molecular
pathways
that
presumably
contribute
manifestation
depression.
Despite
significant
progress
made
by
these
models,
there
are
still
formidable
challenges
will
eventually
be
addressed
platforms,
as
further
studies
may
emerge.
This
review
examine
most
recent
advances
comprehension
depression
using
human
neurons
and
non-neuronal
derived
from
induced
patients
with
highlights
importance
platforms
increase
our
knowledge
address
this
psychiatric
efficiently.
Язык: Английский