Novel Green Approaches for the Preparation of Gold Nanoparticles and Their Promising Potential in Oncology

Processes, Год журнала: 2022, Номер 10(2), С. 426 - 426

Опубликована: Фев. 21, 2022

The difficulty of achieving targeted drug delivery following administration currently marketed anticancer therapeutics is a still concern. Metallic nanoparticles (NPs) developed through nanotechnology breakthroughs appear to be promising in this regard. Research studies pertaining gold NPs have indicated their applicability cancer diagnosis, and therapy. These also recently paved the path for precise site-specific targeting. Our review paper thus highlights scope impact biogenetically generated In critical, constructive, methodical manner, we compare advantages offered by over other metal NPs. Moreover, focus on novel ‘greener’ strategies that been explored preparation shed light disadvantages conventional NP synthesis routes. Future prospects use oncotherapy domains require further investigation are addressed.

Язык: Английский

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Response surface methodology: Optimization of myco-synthesized gold and silver nanoparticles by Trichoderma saturnisporum

Biomass Conversion and Biorefinery, Год журнала: 2023, Номер unknown

Опубликована: Дек. 23, 2023

Abstract In the current study, optimal reaction condition for fabrication of Au and Ag nanoparticles by using Trichoderma saturnisporum was developed. Optimization fermentation conditions extracellular AuNPs AgNPs synthesis response surface methodology achieved. To accomplish ideal state, green reaction’s effective parameters central composite face design were used. Precursor concentrations, pH, temperature found to be most nanomaterials. The model’s realization used a respectable foot. Normal probability plots; interaction plots, including effect variance analysis (ANOVA), contour Pareto charts optimize components. Significance threshold (5%) influence all factors. production process also influenced some potential connections between these recommended regression model fits experimental data extremely well. findings this study looked at how much more bio-fabrication possible with producer compared traditional optimization techniques.

Язык: Английский

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Biogenic synthesis of nanoparticles using microbes and plants: mechanisms and multifaceted applications

International Journal of Environmental & Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 29

Опубликована: Янв. 18, 2024

The utilisation of botanical materials and microorganisms in nanoparticle (NPs) synthesis has emerged as an environmentally sustainable alternative when compared to conventional methodologies which include various hazardous chemical agents. These eco-friendly NPs have recently received attention due their potential applications across diverse fields. Multiple investigations also demonstrated the efficacy environmentally-friendly synthesised nanoparticles medical applications, including targeted drug delivery, cancer therapy, wound healing. Furthermore, green-synthesised exhibit promising environmental remediation, owing remarkable photodegradation capabilities. photocatalysts harnesses light transform pollutants into benign byproducts. Green exceptional effectiveness degrading contaminants, encompassing heavy metals, herbicides, dyes. biogenic using microbes plant-derived represents affordable, beneficial, biologically safe approach. Several been fabricated through bio-reduction biological substances or extracts. Metallic produced natural means adsorption, photocatalysis, water purification. friendly protocols captured significant from scientific community over past decade. This comprehensive review serves a consolidated reference, summarising current relevant research findings pertaining prospective contexts.

Язык: Английский

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ERBB2 as a Multifaceted Biomarker in Head and Neck Squamous Cell Carcinoma: In Silico and In Vitro Evidence

Опубликована: Янв. 1, 2025

Background: Head and neck squamous cell carcinoma (HNSC) is a prevalent aggressive cancer, with ERBB2 (also known as HER2) being gene of interest due to its role in various cancers. This study investigates the expression, promoter methylation, potential prognostic significance HNSC, aiming elucidate disease's progression biomarker. Methods: utilized multiple bioinformatics tools databases, including UALCAN, GEPIA2, cBioPortal, perform expression methylation analyses, survival assessments, enrichment studies. Validation was conducted using RT-qPCR HNSC normal lines. Results: significantly down-regulated samples compared tissues. down-regulation consistent across clinical parameters, age, gender, race, cancer stages. The hypermethylated samples, providing mechanism for reduced expression. Kaplan-Meier analysis revealed that low associated poorer overall patients. Functional analyses indicated genes are involved critical pathways such ErbB signaling pathway, EGFR tyrosine kinase inhibitor resistance, PI3K-Akt pathway. Analysis genetic mutations showed mutation frequency (3%) suggesting minor these disease progression. confirmed lower lines (FaDu Cal27) control (HOK HaCaT). Conclusion: highlights significant hypermethylation which correlates outcomes. These findings suggest plays crucial pathogenesis may serve biomarker therapeutic target this type.

Язык: Английский

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A narrative review on the use of Green synthesized metallic nanoparticles for targeted cancer therapy

Bioorganic Chemistry, Год журнала: 2025, Номер 157, С. 108305 - 108305

Опубликована: Фев. 23, 2025

Язык: Английский

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