Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(7), С. 2815 - 2853
Опубликована: Апрель 24, 2024
Regulated
cell
death
(RCD)
is
a
controlled
form
of
orchestrated
by
one
or
more
cascading
signaling
pathways,
making
it
amenable
to
pharmacological
intervention.
RCD
subroutines
can
be
categorized
as
apoptotic
non-apoptotic
and
play
essential
roles
in
maintaining
homeostasis,
facilitating
development,
modulating
immunity.
Accumulating
evidence
has
recently
revealed
that
evasion
frequently
the
primary
cause
tumor
survival.
Several
have
garnered
attention
promising
cancer
therapies
due
their
ability
induce
regression
prevent
relapse,
comparable
apoptosis.
Moreover,
they
offer
potential
solutions
for
overcoming
acquired
resistance
tumors
toward
drugs.
With
an
increasing
understanding
underlying
mechanisms
governing
these
subroutines,
growing
number
small-molecule
compounds
targeting
single
multiple
pathways
been
discovered,
providing
novel
strategies
current
therapy.
In
this
review,
we
comprehensively
summarized
regulatory
emerging
mainly
including
autophagy-dependent
death,
ferroptosis,
cuproptosis,
disulfidptosis,
necroptosis,
pyroptosis,
alkaliptosis,
oxeiptosis,
parthanatos,
mitochondrial
permeability
transition
(MPT)-driven
necrosis,
entotic
NETotic
lysosome-dependent
immunogenic
(ICD).
Furthermore,
focused
on
discussing
related
compounds.
brief,
insightful
findings
may
provide
valuable
guidance
investigating
individual
collaborative
approaches
towards
different
ultimately
driving
discovery
target
significantly
enhance
future
therapeutics.
Abstract
The
PI3K/AKT/mTOR
(PAM)
signaling
pathway
is
a
highly
conserved
signal
transduction
network
in
eukaryotic
cells
that
promotes
cell
survival,
growth,
and
cycle
progression.
Growth
factor
signalling
to
transcription
factors
the
PAM
axis
regulated
by
multiple
cross-interactions
with
several
other
pathways,
dysregulation
of
can
predispose
cancer
development.
most
frequently
activated
human
often
implicated
resistance
anticancer
therapies.
Dysfunction
components
this
such
as
hyperactivity
PI3K,
loss
function
PTEN,
gain-of-function
AKT,
are
notorious
drivers
treatment
disease
progression
cancer.
In
review
we
highlight
major
dysregulations
cancer,
discuss
results
AKT
mTOR
inhibitors
monotherapy
co-administation
antineoplastic
agents
clinical
trials
strategy
for
overcoming
resistance.
Finally,
mechanisms
targeted
therapies,
including
immunology
immunotherapies
also
discussed.
Signal Transduction and Targeted Therapy,
Год журнала:
2021,
Номер
6(1)
Опубликована: Ноя. 24, 2021
Circular
RNAs
(circRNAs),
covalently
closed
noncoding
RNAs,
are
widely
expressed
in
eukaryotes
and
viruses.
They
can
function
by
regulating
target
gene
expression,
linear
RNA
transcription
protein
generation.
The
phosphoinositide
3-kinase
(PI3K)/AKT
signaling
pathway
plays
key
roles
many
biological
cellular
processes,
such
as
cell
proliferation,
growth,
invasion,
migration,
angiogenesis.
It
also
a
pivotal
role
cancer
progression.
Emerging
data
suggest
that
the
circRNA/PI3K/AKT
axis
modulates
expression
of
cancer-associated
genes
thus
regulates
tumor
Aberrant
regulation
circRNAs
is
significantly
associated
with
clinicopathological
characteristics
an
important
functions.
In
this
review,
we
summarized
functions
PI3K-AKT-related
vitro
vivo
assessed
their
associations
characteristics.
We
further
discussed
diagnosis,
prognostication,
treatment
cancers.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 4, 2023
The
physiological
processes
of
cell
growth,
proliferation,
differentiation,
and
apoptosis
are
closely
related
to
STAT3,
it
has
been
demonstrated
that
aberrant
STAT3
expression
an
impact
on
the
onset
progression
a
number
inflammatory
immunological
disorders,
fibrotic
diseases,
malignancies.
In
order
produce
necessary
biological
effects,
macrophages
(M0)
can
be
polarized
into
pro-inflammatory
(M1)
anti-inflammatory
(M2)
types
in
response
various
microenvironmental
stimuli.
signaling
is
involved
macrophage
polarization,
research
effect
polarization
gained
attention
recent
years.
provide
references
for
treatment
investigation
disorders
this
review
compiles
pertinent
pathways
associated
with
from
many
fundamental
studies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13381 - 13381
Опубликована: Авг. 29, 2023
Diabetes
mellitus
is
a
chronic
multifaceted
disease
with
multiple
potential
complications,
the
treatment
of
which
can
only
delay
and
prolong
terminal
stage
disease,
i.e.,
type
2
diabetes
(T2DM).
The
World
Health
Organization
predicts
that
will
be
seventh
leading
cause
death
by
2030.
Although
many
antidiabetic
medicines
have
been
successfully
developed
in
recent
years,
such
as
GLP-1
receptor
agonists
SGLT-2
inhibitors,
single-target
drugs
are
gradually
failing
to
meet
therapeutic
requirements
owing
individual
variability,
diversity
pathogenesis,
organismal
resistance.
Therefore,
there
remains
need
investigate
pathogenesis
T2DM
more
depth,
identify
targets,
provide
improved
glycemic
control
solutions.
This
review
presents
an
overview
mechanisms
action
development
latest
agents
targeting
years.
It
also
discusses
emerging
target-based
therapies
new
targets
emerged
within
last
three
aim
our
theoretical
basis
for
further
advancement
targeted
T2DM.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 25, 2024
Abstract
Fatty
acid
metabolism,
particularly
fatty
synthesis,
is
a
very
important
cellular
physiological
process
in
which
nutrients
are
used
for
energy
storage
and
biofilm
synthesis.
As
key
enzyme
the
synthase
(FASN)
receiving
increasing
attention.
Although
previous
studies
on
FASN
have
mainly
focused
various
malignancies,
many
recently
reported
that
regulates
survival,
differentiation,
function
of
immune
cells,
subsequently
participates
occurrence
development
immune-related
diseases.
However,
few
to
date
systematically
summarized
molecular
mechanisms
cell
biology
related
In
this
review,
we
discuss
regulatory
effect
progress
research
implications
Understanding
diseases
can
offer
insights
into
novel
treatment
strategies
clinical
Novel
therapeutic
agents
in
clinical
trials
offer
a
paradigm
shift
the
approach
to
battling
this
prevalent
and
destructive
disease,
area
of
cancer
therapy
is
on
precipice
trans
formative
revolution.
Despite
importance
tried-and-true
treatments
like
surgery,
radiation,
chemotherapy,
disease
continues
evolve
adapt,
making
new,
more
potent
methods
necessary.
The
field
currently
witnessing
emergence
wide
range
innovative
approaches.
Immunotherapy,
including
checkpoint
inhibitors,
CAR-T
cell
treatment,
vaccines,
utilizes
host's
immune
system
selectively
target
eradicate
malignant
cells
while
minimizing
harm
normal
tissue.
development
targeted
medicines
kinase
inhibitors
monoclonal
antibodies
has
allowed
for
less
harmful
approaches
treating
cancer.
With
help
genomics
molecular
profiling,
"precision
medicine"
customizes
therapies
each
patient's
unique
genetic
makeup
maximize
efficacy
unwanted
side
effects.
Epigenetic
therapies,
metabolic
interventions,
radio-pharmaceuticals,
an
increasing
emphasis
combination
with
synergistic
effects
further
broaden
landscape.
Multiple-stage
are
essential
determining
safety
these
novel
drugs,
allowing
patients
gain
access
also
furthering
scientific
understanding.
future
rife
promise,
as
integration
artificial
intelligence
big
data
potential
revolutionize
early
detection
prevention.
Collaboration
among
researchers,
healthcare
providers,
active
involvement
remain
bedrock
ongoing
battle
against
In
conclusion,
dynamic
evolving
landscape
provides
hope
improved
treatment
outcomes,
emphasizing
patient-centered,
data-driven,
ethically
grounded
we
collectively
strive
towards
cancer-free
world.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 14, 2024
Abstract
Receptor
tyrosine
kinases
(RTKs),
a
category
of
transmembrane
receptors,
have
gained
significant
clinical
attention
in
oncology
due
to
their
central
role
cancer
pathogenesis.
Genetic
alterations,
including
mutations,
amplifications,
and
overexpression
certain
RTKs,
are
critical
creating
environments
conducive
tumor
development.
Following
discovery,
extensive
research
has
revealed
how
RTK
dysregulation
contributes
oncogenesis,
with
many
subtypes
showing
dependency
on
aberrant
signaling
for
proliferation,
survival
progression.
These
findings
paved
the
way
targeted
therapies
that
aim
inhibit
crucial
biological
pathways
cancer.
As
result,
RTKs
emerged
as
primary
targets
anticancer
therapeutic
Over
past
two
decades,
this
led
synthesis
validation
numerous
small
molecule
kinase
inhibitors
(TKIs),
now
effectively
utilized
treating
various
types.
In
manuscript
we
provide
comprehensive
understanding
context
We
explored
alterations
specific
receptors
across
different
malignancies,
special
dedicated
examination
current
inhibitors,
highlighting
potential
therapies.
By
integrating
latest
evidence,
seek
elucidate
pivotal
biology
efficacy
inhibition
promising
treatment
outcomes.
Antioxidants,
Год журнала:
2024,
Номер
13(2), С. 203 - 203
Опубликована: Фев. 5, 2024
Antioxidant
peptides
are
currently
a
hotspot
in
food
science,
pharmaceuticals,
and
cosmetics.
In
different
fields,
the
screening,
activity
evaluation,
mechanisms,
applications
of
antioxidant
pivotal
areas
research.
Among
these
topics,
efficient
screening
stands
at
forefront
cutting-edge
To
this
end,
with
novel
technologies
has
significantly
accelerated
research
process,
gradually
replacing
traditional
approach.
After
screened
identified,
time-consuming
evaluation
is
another
indispensable
procedure,
especially
vivo
models.
Cellular
rodent
models
have
been
widely
used
for
whilst
non-rodent
provide
an
solution,
even
potential
high-throughput
screening.
Meanwhile,
further
molecular
mechanisms
can
elucidate
essence
underlying
activity,
which
related
to
several
signaling
pathways,
including
Keap1-Nrf2/ARE,
mitochondria-dependent
apoptosis,
TGF-β/SMAD,
AMPK/SIRT1/PGC-1α,
PI3K/Akt/mTOR,
NF-κB.
Last
but
not
least,
broad
manufacture,
therapy,
cosmetics
industry,
requires
systematic
review.
This
review
introduces
peptides,
categorized
new
vision.
A
wide
range
assays,
encompassing
cellular
models,
as
well
provided
comprehensive
manner.
addition,
recent
advances
analyzed
specific
cases.
Finally,
production,
systematically
reviewed.
