Molecular subtyping of small cell lung cancer

Seminars in Cancer Biology, Год журнала: 2022, Номер 86, С. 450 - 462

Опубликована: Май 21, 2022

Язык: Английский

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Identification of Key Biomarkers Associated with Immunogenic Cell Death and Their Regulatory Mechanisms in Severe Acute Pancreatitis Based on WGCNA and Machine Learning

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 3033 - 3033

Опубликована: Фев. 3, 2023

Immunogenic cell death (ICD) is a form of programmed with strong sense inflammatory detection, whose powerful situational awareness can cause the reactivation aberrant immunity. However, role ICD in pathogenesis severe acute pancreatitis (SAP) has yet to be investigated. This study aims explore pivotal genes associated SAP and how they relate immune infiltration short-chain fatty acids (SCFAs), order provide theoretical foundation for further, in-depth mechanistic studies. We downloaded GSE194331 datasets from Gene Expression Omnibus (GEO). The use differentially expressed gene (DEG) analysis; weighted co-expression network analysis (WGCNA) least absolute shrinkage selection operator (LASSO) regression allowed us identify total three ICD-related hub (LY96, BCL2, IFNGR1) SAP. Furthermore, single sample set enrichment (ssGSEA) demonstrated that are closely specific cells, activation pathways metabolism SCFAs (especially butyrate). These findings were validated through expression patterns both clinical patients rat animal models In conclusion, first concept was proposed our study. important implications future investigations into pro-inflammatory mechanisms mediated by damage-associated molecular (DAMPs) late stages

Язык: Английский

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Towards artificial intelligence to multi-omics characterization of tumor heterogeneity in esophageal cancer

Seminars in Cancer Biology, Год журнала: 2023, Номер 91, С. 35 - 49

Опубликована: Март 1, 2023

Язык: Английский

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Revealing the Mutually Enhanced Mechanism of Necroptosis and Immunotherapy Induced by Defect Engineering and Piezoelectric Effect

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Окт. 12, 2023

Abstract Owing to low immunogenicity‐induced immune escape and short‐term circulating responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering immunogenic cell death establishing a long‐term, mutually reinforced treatment modality are urgent challenges. In this study, ultrathin CaBi 2 Nb O 9 nanosheets with tunable oxygen vacancies (abbreviated as CBNO‐OV1) prepared for synergistic necroptosis immunotherapy. The optimized vacancy concentration significantly improves piezoelectric effect under ultrasound irradiation, thereby considerably improving generation reactive species (ROS). Density functional theory shows that can improve electron hole separation by suppressing their recombination, thus resulting in enhanced piezocatalytic activity. Moreover, permeability tumor membranes, Ca 2+ influx. Additionally, CBNO‐OV1 also releases portion , which induces assisted explosive ROS. Ribonucleic acid transcription tests suggest mechanisms associated response activation necroptosis. More importantly, trigger significant vivo, activating macrophage M1 polarization through NF‐kappa B pathway promoting T‐cell differentiation.Tumor Necrosis Factor‐α differentiated from macrophages conversely promotes necroptosis, realizing effect. This study demonstrates feasibility amplifying efficacy.

Язык: Английский

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Nonferrous Ferroptosis Inducer Manganese Molybdate Nanoparticles to Enhance Tumor Immunotherapy

Small, Год журнала: 2023, Номер 19(45)

Опубликована: Июль 7, 2023

Tumor immunotherapy is an important tool in oncology treatment. However, only a small percentage of patients have effective immune response to tumor due the poor infiltration pro-inflammatory cells "cold" tumors and immunosuppressive network microenvironment (TME). Ferroptosis has been widely used as novel strategy enhance immunotherapy. Herein, manganese molybdate nanoparticles (MnMoOx NPs) depleted highly expressed glutathione (GSH) inhibited peroxidase 4 (GPX4) expression, thus triggering ferroptosis, inducing cell death (ICD), further releasing damage-associated molecular patterns (DAMPs), enhancing Furthermore, MnMoOx NPs can efficiently suppress tumors, promote maturation dendritic (DCs), infiltrate T cells, reverse microenvironment, making "hot" tumor. Combination with checkpoint inhibitor (ICI) (α-PD-L1) enhanced anti-tumor effect metastases well. The work provides new idea for development nonferrous inducers ferroptosis cancer

Язык: Английский

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Cancer plasticity in therapy resistance: Mechanisms and novel strategies

Drug Resistance Updates, Год журнала: 2024, Номер 76, С. 101114 - 101114

Опубликована: Июнь 22, 2024

Язык: Английский

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Extracellular vesicle-mediated ferroptosis, pyroptosis, and necroptosis: potential clinical applications in cancer therapy

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Янв. 12, 2024

Abstract Extracellular vesicles (EVs) have gained increasing recognition as significant regulators of intercellular communication in various physiological and pathological processes. These play a pivotal role cancer progression by facilitating the transfer diverse cargoes, including lipids, proteins, nucleic acids. Regulated cell death (RCD), orderly autonomous cells, is controlled variety biomacromolecules and, turn, influences biological processes progression. Recent studies demonstrated that EV cargoes regulate oncogenes tumor suppressors to mediate different nonapoptotic forms RCD, notably ferroptosis, pyroptosis, necroptosis. Nevertheless, comprehensive exploration EV-mediated RCD context has not been performed. This review summarizes progress regarding functions underlying mechanisms EVs mediating delivery Additionally, delves into potential clinical applications its significance areas diagnosis therapy.

Язык: Английский

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Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy

Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 470 - 485

Опубликована: Фев. 2, 2024

Язык: Английский

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Targeting novel regulated cell death: Ferroptosis, pyroptosis and necroptosis in anti‐PD‐1/PD‐L1 cancer immunotherapy

Cell Proliferation, Год журнала: 2024, Номер 57(8)

Опубликована: Апрель 9, 2024

Abstract Chemotherapy, radiotherapy, and immunotherapy represent key tumour treatment strategies. Notably, immune checkpoint inhibitors (ICIs), particularly anti‐programmed cell death 1 (PD1) ligand (PD‐L1), have shown clinical efficacy in immunotherapy. However, the limited effectiveness of ICIs is evident due to many cancers exhibiting poor responses this treatment. An emerging avenue involves triggering non‐apoptotic regulated (RCD), a significant mechanism driving cancer diverse treatments. Recent research demonstrates that combining RCD inducers with significantly enhances their antitumor across various types. The use anti‐PD‐1/PD‐L1 activates CD8 + T cells, prompting initiation novel forms, such as ferroptosis, pyroptosis, necroptosis. functions mechanisms anti‐PD1/PD‐L1 therapy remain insufficiently explored. This review summarises roles necroptosis It emphasises synergy between nanomaterials PD‐1/PD‐L1 induce different Furthermore, targeting signalling pathways combination therapies holds promise prospective strategy for

Язык: Английский

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Enhancing cancer immunotherapy with photodynamic therapy and nanoparticle: making tumor microenvironment hotter to make immunotherapeutic work better

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 5, 2024

Cancer immunotherapy has made tremendous advancements in treating various malignancies. The biggest hurdle to successful would be the immunosuppressive tumor microenvironment (TME) and low immunogenicity of cancer cells. To make successful, ‘cold’ TME must converted ‘hot’ immunostimulatory status activate residual host immune responses. this end, equilibrium should broken, immunogenic cell death ought induced stimulate tumor-killing cells appropriately. Photodynamic therapy (PDT) is an efficient way inducing (ICD) disrupting immune-restrictive tissues. PDT trigger a chain reaction that have ICD-induced antigens presented In principle, strategic combination synergize enhance therapeutic outcomes many intractable tumors. Novel technologies employing nanocarriers were developed deliver photosensitizers immunotherapeutic efficiently. New-generation nanomedicines been for recent years, which will accelerate clinical applications.

Язык: Английский

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