Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machine learning study DOI Creative Commons
Lele Ye,

Chunhao Long,

Binbing Xu

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 8, 2025

Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, programmed cell death (PCD) increasingly recognized as potential target in cancer therapy prognosis. However, PCD-based predictive model for serous ovarian carcinoma (SOC) lacking. In present study, we to establish index (CDI)–based using PCD-related genes. Methods We included 1254 genes from 12 PCD patterns our analysis. Differentially expressed (DEGs) Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were screened. Subsequently, 14 PCD-gene-based CDI model. Genomics, single-cell transcriptomes, bulk spatial clinical information TCGA-OV, GSE26193, GSE63885, GSE140082 collected analyzed verify prediction Results The was an independent prognostic risk factor patients with SOC. Patients SOC high had lower survival rates poorer prognoses than those low CDI. Specific parameters combined nomogram that accurately assessed patient survival. used PCD-genes observe differences between groups. results showed immunosuppression hardly benefited immunotherapy; therefore, trametinib_1372 BMS-754807 may be therapeutic agents these patients. Conclusions CDI-based model, which established genes, predicted tumor microenvironment, immunotherapy response, drug sensitivity Thus this help improve diagnostic efficacy PPPM.

Язык: Английский

Molecular subtyping of small cell lung cancer DOI
Jie Liang,

Xiaojiao Guan,

Guangyao Bao

и другие.

Seminars in Cancer Biology, Год журнала: 2022, Номер 86, С. 450 - 462

Опубликована: Май 21, 2022

Язык: Английский

Процитировано

40
Identification of Key Biomarkers Associated with Immunogenic Cell Death and Their Regulatory Mechanisms in Severe Acute Pancreatitis Based on WGCNA and Machine Learning DOI Open Access
Zhengjian Wang, Jin Liu, Yuting Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 3033 - 3033

Опубликована: Фев. 3, 2023

Immunogenic cell death (ICD) is a form of programmed with strong sense inflammatory detection, whose powerful situational awareness can cause the reactivation aberrant immunity. However, role ICD in pathogenesis severe acute pancreatitis (SAP) has yet to be investigated. This study aims explore pivotal genes associated SAP and how they relate immune infiltration short-chain fatty acids (SCFAs), order provide theoretical foundation for further, in-depth mechanistic studies. We downloaded GSE194331 datasets from Gene Expression Omnibus (GEO). The use differentially expressed gene (DEG) analysis; weighted co-expression network analysis (WGCNA) least absolute shrinkage selection operator (LASSO) regression allowed us identify total three ICD-related hub (LY96, BCL2, IFNGR1) SAP. Furthermore, single sample set enrichment (ssGSEA) demonstrated that are closely specific cells, activation pathways metabolism SCFAs (especially butyrate). These findings were validated through expression patterns both clinical patients rat animal models In conclusion, first concept was proposed our study. important implications future investigations into pro-inflammatory mechanisms mediated by damage-associated molecular (DAMPs) late stages

Язык: Английский

Процитировано

40
Towards artificial intelligence to multi-omics characterization of tumor heterogeneity in esophageal cancer DOI
Junyu Li, Lin Li,

Peimeng You

и другие.

Seminars in Cancer Biology, Год журнала: 2023, Номер 91, С. 35 - 49

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

30
Revealing the Mutually Enhanced Mechanism of Necroptosis and Immunotherapy Induced by Defect Engineering and Piezoelectric Effect DOI Open Access

Yaqian Du,

Jiani Yang,

Fei He

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Окт. 12, 2023

Abstract Owing to low immunogenicity‐induced immune escape and short‐term circulating responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering immunogenic cell death establishing a long‐term, mutually reinforced treatment modality are urgent challenges. In this study, ultrathin CaBi 2 Nb O 9 nanosheets with tunable oxygen vacancies (abbreviated as CBNO‐OV1) prepared for synergistic necroptosis immunotherapy. The optimized vacancy concentration significantly improves piezoelectric effect under ultrasound irradiation, thereby considerably improving generation reactive species (ROS). Density functional theory shows that can improve electron hole separation by suppressing their recombination, thus resulting in enhanced piezocatalytic activity. Moreover, permeability tumor membranes, Ca 2+ influx. Additionally, CBNO‐OV1 also releases portion , which induces assisted explosive ROS. Ribonucleic acid transcription tests suggest mechanisms associated response activation necroptosis. More importantly, trigger significant vivo, activating macrophage M1 polarization through NF‐kappa B pathway promoting T‐cell differentiation.Tumor Necrosis Factor‐α differentiated from macrophages conversely promotes necroptosis, realizing effect. This study demonstrates feasibility amplifying efficacy.

Язык: Английский

Процитировано

30
Nonferrous Ferroptosis Inducer Manganese Molybdate Nanoparticles to Enhance Tumor Immunotherapy DOI Open Access

Huali Lei,

Quguang Li, Zifan Pei

и другие.

Small, Год журнала: 2023, Номер 19(45)

Опубликована: Июль 7, 2023

Tumor immunotherapy is an important tool in oncology treatment. However, only a small percentage of patients have effective immune response to tumor due the poor infiltration pro-inflammatory cells "cold" tumors and immunosuppressive network microenvironment (TME). Ferroptosis has been widely used as novel strategy enhance immunotherapy. Herein, manganese molybdate nanoparticles (MnMoOx NPs) depleted highly expressed glutathione (GSH) inhibited peroxidase 4 (GPX4) expression, thus triggering ferroptosis, inducing cell death (ICD), further releasing damage-associated molecular patterns (DAMPs), enhancing Furthermore, MnMoOx NPs can efficiently suppress tumors, promote maturation dendritic (DCs), infiltrate T cells, reverse microenvironment, making "hot" tumor. Combination with checkpoint inhibitor (ICI) (α-PD-L1) enhanced anti-tumor effect metastases well. The work provides new idea for development nonferrous inducers ferroptosis cancer

Язык: Английский

Процитировано

29
Targeting novel regulated cell death: Ferroptosis, pyroptosis and necroptosis in anti‐PD‐1/PD‐L1 cancer immunotherapy DOI Creative Commons
Li Yu, Ke Huang, Yixiang Liao

и другие.

Cell Proliferation, Год журнала: 2024, Номер 57(8)

Опубликована: Апрель 9, 2024

Abstract Chemotherapy, radiotherapy, and immunotherapy represent key tumour treatment strategies. Notably, immune checkpoint inhibitors (ICIs), particularly anti‐programmed cell death 1 (PD1) ligand (PD‐L1), have shown clinical efficacy in immunotherapy. However, the limited effectiveness of ICIs is evident due to many cancers exhibiting poor responses this treatment. An emerging avenue involves triggering non‐apoptotic regulated (RCD), a significant mechanism driving cancer diverse treatments. Recent research demonstrates that combining RCD inducers with significantly enhances their antitumor across various types. The use anti‐PD‐1/PD‐L1 activates CD8 + T cells, prompting initiation novel forms, such as ferroptosis, pyroptosis, necroptosis. functions mechanisms anti‐PD1/PD‐L1 therapy remain insufficiently explored. This review summarises roles necroptosis It emphasises synergy between nanomaterials PD‐1/PD‐L1 induce different Furthermore, targeting signalling pathways combination therapies holds promise prospective strategy for

Язык: Английский

Процитировано

17
Cancer plasticity in therapy resistance: Mechanisms and novel strategies DOI

Xing Niu,

Wenjing Liu,

Zhang Yinling

и другие.

Drug Resistance Updates, Год журнала: 2024, Номер 76, С. 101114 - 101114

Опубликована: Июнь 22, 2024

Язык: Английский

Процитировано

17
Extracellular vesicle-mediated ferroptosis, pyroptosis, and necroptosis: potential clinical applications in cancer therapy DOI Creative Commons

Yi-Chi Yang,

Qian Jiang,

Ke-Ping Yang

и другие.

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Янв. 12, 2024

Abstract Extracellular vesicles (EVs) have gained increasing recognition as significant regulators of intercellular communication in various physiological and pathological processes. These play a pivotal role cancer progression by facilitating the transfer diverse cargoes, including lipids, proteins, nucleic acids. Regulated cell death (RCD), orderly autonomous cells, is controlled variety biomacromolecules and, turn, influences biological processes progression. Recent studies demonstrated that EV cargoes regulate oncogenes tumor suppressors to mediate different nonapoptotic forms RCD, notably ferroptosis, pyroptosis, necroptosis. Nevertheless, comprehensive exploration EV-mediated RCD context has not been performed. This review summarizes progress regarding functions underlying mechanisms EVs mediating delivery Additionally, delves into potential clinical applications its significance areas diagnosis therapy.

Язык: Английский

Процитировано

14
Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy DOI

Shiquan Sun,

Yong He,

Jiaqi Xu

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 470 - 485

Опубликована: Фев. 2, 2024

Язык: Английский

Процитировано

14
Enhancing cancer immunotherapy with photodynamic therapy and nanoparticle: making tumor microenvironment hotter to make immunotherapeutic work better DOI Creative Commons

Jayalakshmi Thiruppathi,

Veena Vijayan, In‐Kyu Park

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 5, 2024

Cancer immunotherapy has made tremendous advancements in treating various malignancies. The biggest hurdle to successful would be the immunosuppressive tumor microenvironment (TME) and low immunogenicity of cancer cells. To make successful, ‘cold’ TME must converted ‘hot’ immunostimulatory status activate residual host immune responses. this end, equilibrium should broken, immunogenic cell death ought induced stimulate tumor-killing cells appropriately. Photodynamic therapy (PDT) is an efficient way inducing (ICD) disrupting immune-restrictive tissues. PDT trigger a chain reaction that have ICD-induced antigens presented In principle, strategic combination synergize enhance therapeutic outcomes many intractable tumors. Novel technologies employing nanocarriers were developed deliver photosensitizers immunotherapeutic efficiently. New-generation nanomedicines been for recent years, which will accelerate clinical applications.

Язык: Английский

Процитировано

12