Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Янв. 8, 2025
Abstract
Background
Predictive,
preventive,
and
personalized
medicine
(PPPM/3PM)
is
a
strategy
aimed
at
improving
the
prognosis
of
cancer,
programmed
cell
death
(PCD)
increasingly
recognized
as
potential
target
in
cancer
therapy
prognosis.
However,
PCD-based
predictive
model
for
serous
ovarian
carcinoma
(SOC)
lacking.
In
present
study,
we
to
establish
index
(CDI)–based
using
PCD-related
genes.
Methods
We
included
1254
genes
from
12
PCD
patterns
our
analysis.
Differentially
expressed
(DEGs)
Cancer
Genome
Atlas
(TCGA)
Genotype-Tissue
Expression
(GTEx)
were
screened.
Subsequently,
14
PCD-gene-based
CDI
model.
Genomics,
single-cell
transcriptomes,
bulk
spatial
clinical
information
TCGA-OV,
GSE26193,
GSE63885,
GSE140082
collected
analyzed
verify
prediction
Results
The
was
an
independent
prognostic
risk
factor
patients
with
SOC.
Patients
SOC
high
had
lower
survival
rates
poorer
prognoses
than
those
low
CDI.
Specific
parameters
combined
nomogram
that
accurately
assessed
patient
survival.
used
PCD-genes
observe
differences
between
groups.
results
showed
immunosuppression
hardly
benefited
immunotherapy;
therefore,
trametinib_1372
BMS-754807
may
be
therapeutic
agents
these
patients.
Conclusions
CDI-based
model,
which
established
genes,
predicted
tumor
microenvironment,
immunotherapy
response,
drug
sensitivity
Thus
this
help
improve
diagnostic
efficacy
PPPM.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 3033 - 3033
Опубликована: Фев. 3, 2023
Immunogenic
cell
death
(ICD)
is
a
form
of
programmed
with
strong
sense
inflammatory
detection,
whose
powerful
situational
awareness
can
cause
the
reactivation
aberrant
immunity.
However,
role
ICD
in
pathogenesis
severe
acute
pancreatitis
(SAP)
has
yet
to
be
investigated.
This
study
aims
explore
pivotal
genes
associated
SAP
and
how
they
relate
immune
infiltration
short-chain
fatty
acids
(SCFAs),
order
provide
theoretical
foundation
for
further,
in-depth
mechanistic
studies.
We
downloaded
GSE194331
datasets
from
Gene
Expression
Omnibus
(GEO).
The
use
differentially
expressed
gene
(DEG)
analysis;
weighted
co-expression
network
analysis
(WGCNA)
least
absolute
shrinkage
selection
operator
(LASSO)
regression
allowed
us
identify
total
three
ICD-related
hub
(LY96,
BCL2,
IFNGR1)
SAP.
Furthermore,
single
sample
set
enrichment
(ssGSEA)
demonstrated
that
are
closely
specific
cells,
activation
pathways
metabolism
SCFAs
(especially
butyrate).
These
findings
were
validated
through
expression
patterns
both
clinical
patients
rat
animal
models
In
conclusion,
first
concept
was
proposed
our
study.
important
implications
future
investigations
into
pro-inflammatory
mechanisms
mediated
by
damage-associated
molecular
(DAMPs)
late
stages
Advanced Materials,
Год журнала:
2023,
Номер
36(6)
Опубликована: Окт. 12, 2023
Abstract
Owing
to
low
immunogenicity‐induced
immune
escape
and
short‐term
circulating
responses,
the
efficiency
of
immunotherapy
is
unsatisfactory.
Therefore,
triggering
immunogenic
cell
death
establishing
a
long‐term,
mutually
reinforced
treatment
modality
are
urgent
challenges.
In
this
study,
ultrathin
CaBi
2
Nb
O
9
nanosheets
with
tunable
oxygen
vacancies
(abbreviated
as
CBNO‐OV1)
prepared
for
synergistic
necroptosis
immunotherapy.
The
optimized
vacancy
concentration
significantly
improves
piezoelectric
effect
under
ultrasound
irradiation,
thereby
considerably
improving
generation
reactive
species
(ROS).
Density
functional
theory
shows
that
can
improve
electron
hole
separation
by
suppressing
their
recombination,
thus
resulting
in
enhanced
piezocatalytic
activity.
Moreover,
permeability
tumor
membranes,
Ca
2+
influx.
Additionally,
CBNO‐OV1
also
releases
portion
,
which
induces
assisted
explosive
ROS.
Ribonucleic
acid
transcription
tests
suggest
mechanisms
associated
response
activation
necroptosis.
More
importantly,
trigger
significant
vivo,
activating
macrophage
M1
polarization
through
NF‐kappa
B
pathway
promoting
T‐cell
differentiation.Tumor
Necrosis
Factor‐α
differentiated
from
macrophages
conversely
promotes
necroptosis,
realizing
effect.
This
study
demonstrates
feasibility
amplifying
efficacy.
Tumor
immunotherapy
is
an
important
tool
in
oncology
treatment.
However,
only
a
small
percentage
of
patients
have
effective
immune
response
to
tumor
due
the
poor
infiltration
pro-inflammatory
cells
"cold"
tumors
and
immunosuppressive
network
microenvironment
(TME).
Ferroptosis
has
been
widely
used
as
novel
strategy
enhance
immunotherapy.
Herein,
manganese
molybdate
nanoparticles
(MnMoOx
NPs)
depleted
highly
expressed
glutathione
(GSH)
inhibited
peroxidase
4
(GPX4)
expression,
thus
triggering
ferroptosis,
inducing
cell
death
(ICD),
further
releasing
damage-associated
molecular
patterns
(DAMPs),
enhancing
Furthermore,
MnMoOx
NPs
can
efficiently
suppress
tumors,
promote
maturation
dendritic
(DCs),
infiltrate
T
cells,
reverse
microenvironment,
making
"hot"
tumor.
Combination
with
checkpoint
inhibitor
(ICI)
(α-PD-L1)
enhanced
anti-tumor
effect
metastases
well.
The
work
provides
new
idea
for
development
nonferrous
inducers
ferroptosis
cancer
Cell Proliferation,
Год журнала:
2024,
Номер
57(8)
Опубликована: Апрель 9, 2024
Abstract
Chemotherapy,
radiotherapy,
and
immunotherapy
represent
key
tumour
treatment
strategies.
Notably,
immune
checkpoint
inhibitors
(ICIs),
particularly
anti‐programmed
cell
death
1
(PD1)
ligand
(PD‐L1),
have
shown
clinical
efficacy
in
immunotherapy.
However,
the
limited
effectiveness
of
ICIs
is
evident
due
to
many
cancers
exhibiting
poor
responses
this
treatment.
An
emerging
avenue
involves
triggering
non‐apoptotic
regulated
(RCD),
a
significant
mechanism
driving
cancer
diverse
treatments.
Recent
research
demonstrates
that
combining
RCD
inducers
with
significantly
enhances
their
antitumor
across
various
types.
The
use
anti‐PD‐1/PD‐L1
activates
CD8
+
T
cells,
prompting
initiation
novel
forms,
such
as
ferroptosis,
pyroptosis,
necroptosis.
functions
mechanisms
anti‐PD1/PD‐L1
therapy
remain
insufficiently
explored.
This
review
summarises
roles
necroptosis
It
emphasises
synergy
between
nanomaterials
PD‐1/PD‐L1
induce
different
Furthermore,
targeting
signalling
pathways
combination
therapies
holds
promise
prospective
strategy
for
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Янв. 12, 2024
Abstract
Extracellular
vesicles
(EVs)
have
gained
increasing
recognition
as
significant
regulators
of
intercellular
communication
in
various
physiological
and
pathological
processes.
These
play
a
pivotal
role
cancer
progression
by
facilitating
the
transfer
diverse
cargoes,
including
lipids,
proteins,
nucleic
acids.
Regulated
cell
death
(RCD),
orderly
autonomous
cells,
is
controlled
variety
biomacromolecules
and,
turn,
influences
biological
processes
progression.
Recent
studies
demonstrated
that
EV
cargoes
regulate
oncogenes
tumor
suppressors
to
mediate
different
nonapoptotic
forms
RCD,
notably
ferroptosis,
pyroptosis,
necroptosis.
Nevertheless,
comprehensive
exploration
EV-mediated
RCD
context
has
not
been
performed.
This
review
summarizes
progress
regarding
functions
underlying
mechanisms
EVs
mediating
delivery
Additionally,
delves
into
potential
clinical
applications
its
significance
areas
diagnosis
therapy.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 5, 2024
Cancer
immunotherapy
has
made
tremendous
advancements
in
treating
various
malignancies.
The
biggest
hurdle
to
successful
would
be
the
immunosuppressive
tumor
microenvironment
(TME)
and
low
immunogenicity
of
cancer
cells.
To
make
successful,
‘cold’
TME
must
converted
‘hot’
immunostimulatory
status
activate
residual
host
immune
responses.
this
end,
equilibrium
should
broken,
immunogenic
cell
death
ought
induced
stimulate
tumor-killing
cells
appropriately.
Photodynamic
therapy
(PDT)
is
an
efficient
way
inducing
(ICD)
disrupting
immune-restrictive
tissues.
PDT
trigger
a
chain
reaction
that
have
ICD-induced
antigens
presented
In
principle,
strategic
combination
synergize
enhance
therapeutic
outcomes
many
intractable
tumors.
Novel
technologies
employing
nanocarriers
were
developed
deliver
photosensitizers
immunotherapeutic
efficiently.
New-generation
nanomedicines
been
for
recent
years,
which
will
accelerate
clinical
applications.