Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1514 - 1514
Опубликована: Май 17, 2023
At
present,
colorectal
cancer
(CRC)
is
the
second
deadliest
type
of
cancer,
partly
because
a
high
percentage
cases
are
diagnosed
at
advanced
stages
when
tumors
have
already
metastasized.
Thus,
there
an
urgent
need
to
develop
novel
diagnostic
systems
that
allow
early
detection
as
well
new
therapeutic
more
specific
than
those
currently
available.
In
this
context,
nanotechnology
plays
very
important
role
in
development
targeted
platforms.
recent
decades,
many
types
nanomaterials
with
advantageous
properties
been
used
for
nano-oncology
applications
and
loaded
different
agents,
capable
recognizing
tumor
cells
or
biomarkers.
Indeed,
among
most
widely
monoclonal
antibodies,
administration
them
approved
by
main
drug
regulatory
agencies
treatment
several
including
CRC.
way,
review
comprehensively
discusses
drawbacks
conventional
screening
technologies
CRC,
it
presents
advances
application
antibody-loaded
nanoplatforms
CRC
detection,
therapy
theranostics
applications.
Indus journal of bioscience research.,
Год журнала:
2025,
Номер
3(1), С. 429 - 437
Опубликована: Янв. 20, 2025
Plant
virus
nanoparticles
(VNPs)
are
inexpensive
to
produce,
dependable,
and
reusable
have
emerged
as
a
versatile
promising
platform
in
nanomedicine,
particularly
cancer
therapy.
These
biogenic
nanostructures
possess
unique
physicochemical
properties,
including
biocompatibility,
biodegradability,
structural
uniformity,
making
them
ideal
candidates
for
targeted
drug
delivery.
The
ability
of
such
encapsulate
chemotherapeutic
agents
functionalize
with
tumor-specific
ligands
facilitates
precise
delivery
cancerous
tissues,
minimizing
off-target
effects
enhancing
therapeutic
efficacy.
In
addition,
plant
viral
vectors
(VLPs)
an
attractive
option
causing
anti-tumor
immunity
because
they
undoubtedly
secure,
harmless,
suitable
mass
manufacture
pharmacological
adaptation.
This
review
delves
into
the
molecular
architecture
nanoparticles,
their
functional
modifications,
mechanisms
by
which
interact
cells.
Additionally,
it
highlights
preclinical
studies
emerging
clinical
applications,
addressing
both
opportunities
challenges
translating
VNPs
from
bench
bedside.
By
exploring
anticancer
potentials
VNPs,
this
paper
aims
underscore
role
shaping
future
sustainable,
plant-derived
nanotechnology
oncology.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Янв. 23, 2025
With
the
rapid
development
of
nanotechnology,
nanoultrasonography
has
emerged
as
a
promising
medical
imaging
technique
that
demonstrates
significant
potential
in
diagnosis
and
treatment
gastrointestinal
(GI)
diseases.
This
review
discusses
applications
field,
including
improvements
resolution,
diagnostic
accuracy,
latest
research
findings,
prospects
for
clinical
application.
By
analyzing
existing
literature,
we
explore
role
enhancing
enabling
targeted
drug
delivery,
improving
therapeutic
outcomes,
thereby
providing
reference
future
directions.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 21, 2025
Purpose
This
meta-analysis
aimed
to
compare
the
diagnostic
effectiveness
of
[
68
Ga]Ga-FAPI-04
PET
and
18
F]FDG
for
detecting
lymph
node
metastasis
in
digestive
system
cancer
patients.
Methods
A
comprehensive
search
PubMed,
Web
Science,
Embase
databases
was
conducted
identify
relevant
articles
up
June
2024.
Studies
were
included
if
they
evaluated
performance
Sensitivity
specificity
assessed
using
DerSimonian
Laird
method
transformed
Freeman-Tukey
double
arcsine
transformation.
Results
Fifteen
articles,
encompassing
a
total
617
patients,
this
study.
The
overall
sensitivity
diagnosing
cancers
0.82
(95%
CI:
0.67–0.93),
0.91
0.84–0.97).
In
comparison,
0.51
0.38–0.63),
with
0.81
0.64–0.94).
These
results
suggest
that
has
significantly
higher
(
P
<
0.01)
similar
=
0.20)
compared
cancers.
Conclusion
Our
indicates
However,
high
heterogeneity
among
studies
may
impact
robustness
current
evidence.
Therefore,
future
research
should
prioritize
larger
prospective
more
diverse
populations
specific
subtypes
draw
definitive
conclusions.
Systematic
review
registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024572412
,
Unique
Identifier:
CRD42024572412.
Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
Abstract
Background
Colorectal
cancer
(CRC)
is
a
prominent
global
with
high
mortality
rates
among
human
beings.
Efficient
diagnosis
and
treatment
have
always
been
challenge
for
CRC
management.
Fluorescence
guided
therapy,
which
combines
therapy
into
one
platform,
has
brought
new
chance
achieving
precise
theranostics.
Among
this,
photosensitizers,
applied
in
photodynamic
(PDT),
given
the
integration
of
real-time
imaging
capacity
efficacious
feasibility,
show
great
potential
to
serve
as
remarkable
tools.
Although
much
effort
put
constructing
photosensitizers
locating
destroying
cells,
it
still
need
develop
novel
attain
specific
detection
fulfil
effective
therapy.
Methods
Probe
HTI
was
rational
synthesized
CRC.
Spectrometric
determination
carried
out
first,
followed
by
1
O
2
generation
ability
test.
Then,
displayed
distinguishing
cells
from
normal
Further,
PDT
effect
photosensitizer
studied
vitro.
Additionally,
used
BALB/c
nude
mice
model
validate
its
viscosity
labelling
tumor
suppression
characteristics.
Results
We
successfully
fabricated
mitochondrial
targeting
probe,
HTI,
together
sensitivity,
ultralow
background
interference,
excellent
capacity.
favorably
detection,
displaying
11-fold
fluorescent
intensity
enhancement
solvents
1.57
cp
2043
cp.
demonstrated
that
could
distinguish
upon
difference
viscosity.
Moreover,
qualified
producing
efficiency
supported
sparkling
signals
DCFH
after
incubation
under
light
irradiation.
More
importantly,
performance
CDX
determined,
enriching
multifunctional
validation
vivo.
Conclusions
In
this
study,
sensitive
response
possess
Both
vitro
cell
vivo
trials
proved
effectively
served
robust
scaffold
labeling
clearance.
This
breakthrough
discovery
held
immense
advancing
early
management
through
PDT.
By
leveraging
HTI's
properties,
medical
professionals
benefit
improved
diagnostic
accuracy
targeted
management,
ultimately
leading
enhanced
patient
outcomes.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1706 - 1706
Опубликована: Июнь 10, 2023
Cancer
is
a
top
global
public
health
concern.
At
present,
molecular
targeted
therapy
has
emerged
as
one
of
the
main
therapies
for
cancer,
with
high
efficacy
and
safety.
The
medical
world
continues
to
struggle
development
efficient,
extremely
selective,
low-toxicity
anticancer
medications.
Heterocyclic
scaffolds
based
on
structure
tumor
therapeutic
targets
are
widely
used
in
drug
design.
In
addition,
revolution
medicine
been
brought
by
quick
advancement
nanotechnology.
Many
nanomedicines
have
taken
cancer
new
level.
this
review,
we
highlight
heterocyclic
molecular-targeted
drugs
well
heterocyclic-associated
cancer.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 806 - 806
Опубликована: Июнь 14, 2024
Pancreatic
cancer
(PC)
is
characterized
by
its
notably
poor
prognosis
and
high
mortality
rate,
underscoring
the
critical
need
for
advancements
in
diagnosis
therapy.
Gold
nanoparticles
(AuNPs),
with
their
distinctive
physicochemical
characteristics,
demonstrate
significant
application
potential
For
example,
upon
exposure
to
lasers
of
certain
wavelengths,
they
facilitate
localized
heating,
rendering
them
extremely
effective
photothermal
Additionally,
extensive
surface
area
enables
conjugation
therapeutic
agents
or
targeting
molecules,
increasing
accuracy
drug
delivery
systems.
Moreover,
AuNPs
can
serve
as
radiosensitizers,
enhancing
efficacy
radiotherapy
boosting
radiation
absorption
tumor
cells.
Here,
we
systematically
reviewed
future
directions
treatment
PC.
Although
have
advantages
improving
diagnostic
efficacy,
well
minimizing
damage
normal
tissues,
concerns
about
toxicity
safety
be
comprehensively
evaluated.
