Nutrition Reviews,
Год журнала:
2023,
Номер
82(9), С. 1281 - 1291
Опубликована: Окт. 30, 2023
Cancer
is
a
mysterious
disease.
Among
other
alterations,
tumor
cells,
importantly,
have
metabolic
modifications.
A
well-known
modification
commonly
observed
in
cancer
cells
has
been
termed
the
Warburg
effect.
This
phenomenon
defined
as
high
preference
for
glucose
uptake,
and
increased
lactate
production
from
that
glucose,
even
when
oxygen
readily
available.
Some
anti-cancer
drugs
target
proposed
effect,
some
dietary
regimens
can
function
similarly.
However,
most
suitable
strategies
treating
particular
cancers
are
not
yet
well
understood.
The
aim
of
this
review
was
to
describe
findings
regarding
impact
various
targeting
evidence
suggests
combining
routine
therapies
with
diet-based
may
improve
outcome
cancer.
designing
individualized
must
be
our
ultimate
goal.
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 22, 2025
Abstract
Combining
metabolic
therapy
with
photothermal
(PTT)
shows
promise
for
the
treatment
of
triple‐negative
breast
cancer
(TNBC).
However,
a
strategy
is
still
required
to
effectively
overcome
adaptation
TNBC
thermotolerance
during
thermotherapy,
thereby
enhancing
therapeutic
outcomes.
In
this
study,
polydopamine‐integrated
nanomedicine
designed,
glucose
oxidase
(GOx)
chemically
conjugated
its
surface
and
curcumin
(Cur)‐loaded
calcium
phosphate
(CaP)
shell.
The
outer
CaP
layer
disintegrates
in
response
acidic
environment
tumor
cells,
releasing
ions
efflux
inhibitor
Cur,
which
causes
mitochondrial
functional
disruption
by
inducing
overload.
Concurrently,
GOx
consumes
intracellular
inhibit
glycolysis.
dual
intervention
metabolism
glycolysis
serves
counteract
adaptations
TNBC,
blocking
pathways
energy
supply,
results
56.61%
reduction
ATP.
addition,
inhibition
ATP
production
regulation
can
downregulate
expression
heat
shock
proteins
(HSPs)
sensitized
PTT,
HSP70
level
HSP90
are
downregulated
25.68%
41.89%,
respectively.
This
study
provides
new
insights
into
combining
PTT
TNBC.
Molecular Therapy — Oncolytics,
Год журнала:
2023,
Номер
28, С. 212 - 229
Опубликована: Фев. 6, 2023
Breast
cancer
is
the
leading
cause
of
cancer-related
deaths
in
females
worldwide,
and
liver
one
most
common
sites
distant
metastases
breast
patients.
Patients
with
face
limited
treatment
options,
drug
resistance
highly
prevalent,
to
a
poor
prognosis
short
survival.
Liver
respond
extremely
poorly
immunotherapy
have
shown
treatments
such
as
chemotherapy
targeted
therapies.
Therefore,
develop
optimize
strategies
well
explore
potential
therapeutic
approaches,
it
crucial
understand
mechanisms
In
this
review,
we
summarize
recent
advances
research
discuss
their
for
improving
patient
prognoses
outcomes.
International Journal of Biological Sciences,
Год журнала:
2023,
Номер
20(2), С. 516 - 536
Опубликована: Дек. 5, 2023
A
key
player
in
mitochondrial
respiration,
p32,
often
referred
to
as
C1QBP,
is
mostly
found
the
matrix.
Previously,
we
showed
that
p32
interacts
with
DLAT
mitochondria.
Here,
expression
was
reduced
ccRCC
and
suppressed
progression
metastasis
animal
models.
We
observed
increasing
led
an
increase
oxidative
phosphorylation
by
interacting
DLAT,
thus,
regulating
activation
of
pyruvate
dehydrogenase
complex
(PDHc).
Mechanistically,
expression,
concert
suppresses
PDHc
activity
TCA
cycle.
Furthermore,
our
research
discovered
has
a
direct
binding
affinity
for
copper,
facilitating
copper-induced
oligomerization
lipo-DLAT
specifically
cells.
This
finding
reveals
innovative
function
p32/DLAT/copper
glycometabolism
cycle
ccRCC.
Importantly,
provides
important
new
understandings
underlying
molecular
processes
causing
abnormal
metabolism
linked
this
cancer.
Nutrition Reviews,
Год журнала:
2023,
Номер
82(9), С. 1281 - 1291
Опубликована: Окт. 30, 2023
Cancer
is
a
mysterious
disease.
Among
other
alterations,
tumor
cells,
importantly,
have
metabolic
modifications.
A
well-known
modification
commonly
observed
in
cancer
cells
has
been
termed
the
Warburg
effect.
This
phenomenon
defined
as
high
preference
for
glucose
uptake,
and
increased
lactate
production
from
that
glucose,
even
when
oxygen
readily
available.
Some
anti-cancer
drugs
target
proposed
effect,
some
dietary
regimens
can
function
similarly.
However,
most
suitable
strategies
treating
particular
cancers
are
not
yet
well
understood.
The
aim
of
this
review
was
to
describe
findings
regarding
impact
various
targeting
evidence
suggests
combining
routine
therapies
with
diet-based
may
improve
outcome
cancer.
designing
individualized
must
be
our
ultimate
goal.
