Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117934 - 117934
Опубликована: Фев. 21, 2025
Язык: Английский
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217567 - 217567
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 27, 2025
Abstract Methyltransferase-like 1 (METTL1)-mediated m7G modification is a common occurrence in various RNA species, including mRNAs, tRNAs, rRNAs, and miRNAs. Recent evidence suggests that this linked to the development of several cancers, making it promising target for cancer therapy. However, specific role cutaneous squamous cell carcinoma (cSCC) not well understood. In study, we observed conspicuously elevated levels METTL1 cSCC tumors lines. Inhibiting led reduced survival, migration, invasion, xenograft tumor growth cells. Mechanistically, through combination sequencing, methylated immunoprecipitation (MeRIP)-qPCR, mRNA stability assays, discovered responsible ATF4 mRNA, leading increased expression ATF4. Importantly, demonstrated dependent on methyltransferase activity METTL1. Additionally, positive association between tumors. Intriguingly, restoring cells only promoted glycolysis but also reversed anti-tumor effects knockdown. conclusion, our results underscore critical tumorigenesis, suggesting future therapies.
Язык: Английский
Процитировано
1
Journal of Personalized Medicine, Год журнала: 2025, Номер 15(2), С. 50 - 50
Опубликована: Янв. 27, 2025
Drug resistance remains a significant barrier to effective cancer therapy. Cancer cells evade treatment by reprogramming their metabolism, switching from glycolysis oxidative phosphorylation (OXPHOS), and relying on alternative carbon sources such as glutamine. These adaptations not only enable tumor survival but also contribute immune evasion through mechanisms reactive oxygen species (ROS) generation the upregulation of checkpoint molecules like PD-L1. This review explores potential targeting metabolic weaknesses in drug-resistant cancers enhance therapeutic efficacy. Key pathways involved resistance, including glycolysis, glutamine kynurenine pathway, are discussed. The combination inhibitors with (ICIs), particularly anti-PD-1/PD-L1 therapies, represents promising approach overcoming both mechanisms. Clinical trials combining therapies have shown early promise, further research is needed optimize combinations identify biomarkers for patient selection. In conclusion, metabolism blockade offers novel drug providing pathway improved outcomes Future directions include personalized treatments based profiles expanding other types.
Язык: Английский
Процитировано
1
Frontiers in Marine Science, Год журнала: 2025, Номер 12
Опубликована: Фев. 5, 2025
This study evaluated the effects of hypoxia on heart juvenile four-finger threadfin ( Eleutheronema tetradactylum ) through physiological and transcriptome analysis. Juveniles with an average weight 122.82 g length 24.60 cm were used. Hypoxia significantly increased serum myocardial enzyme activities, including creatine kinase (CK), kinase-MB isoenzyme, lactate dehydrogenase (LDH), α-hydroxybutyrate (HDBH). These indicators initially rose then declined, reflecting cardiac stress suggesting their potential as early biomarkers for real-time aquaculture monitoring. Histological analysis revealed structural damage in fibers under hypoxia, increasing severity over time. underscores need to minimize oxygen fluctuations prevent tissue degeneration. Transcriptome identified upregulated genes involved cell communication, immune responses, intracellular signaling, offering targets breeding hypoxia-tolerant species. Kyoto Encyclopedia Genes Genomes pathway enrichment highlighted key pathways such mitogen-activated protein (MAPK), hypoxia-inducible factor-1 (HIF-1), endocytosis, phagosome formation. The MAPK plays a critical role cellular survival, proliferation, apoptosis. Hypoxia-induced activation MAPKs like ERK, JNK, p38 regulates stress-responsive genes. HIF-1 signaling homeostasis, HIF-1α stabilizing hypoxia-responsive VEGFA, which promotes vascular remodeling enhances delivery. findings collectively offer practical applications enhancing management, monitoring biochemical markers, adopting breeding, adjusting environmental conditions mitigate stress, ensuring better productivity sustainability. research provides foundation further studies molecular mechanisms
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117934 - 117934
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1