Journal of Orthopaedic Surgery and Research,
Год журнала:
2023,
Номер
18(1)
Опубликована: Дек. 9, 2023
Abstract
Background
It
has
previously
been
proven
that
circadian
rhythm
disruption
is
associated
with
the
incidence
and
deterioration
of
several
tumors,
which
potentially
leads
to
increased
tumor
susceptibility
a
worse
prognosis
for
tumor-bearing
patients.
However,
their
potential
role
in
osteosarcoma
yet
be
sufficiently
investigated.
Methods
Transcriptomic
clinical
data
84
samples
70
normal
bone
tissue
were
obtained
from
TARGET
GTEx
databases,
rhythm-related
genes
Genecards,
lncRNAs
(CRLs)
by
Pearson
correlation
analysis,
differential
expression
protein–protein
interaction
(PPI)
analysis.
COX
regression
LASSO
performed
on
CRLs
order
construct
prognostic
prediction
signature
(CRPS).
CRPS
reliability
was
verified
Kaplan–Meier
(KM),
principal
component
analysis
(PCA),
nomogram,
receiver
operating
characteristic
(ROC)
curve.
effects
immune
microenvironment
explored
enrichment
infiltration
effect
critical
gene
RP11-414H17.5
experimentally
verified.
Result
consisting
three
constructed
its
area
under
curve
(AUC)
values
predicted
reached
0.892
training
group
0.843
test
group,
p
value
<
0.05
KM
stable
performance
across
different
subgroups.
PCA
found
could
significantly
distinguish
between
risk
subgroups,
exhibited
excellent
microenvironment.
The
experiment
can
promote
metastasis
inhibit
apoptosis
cells.
Conclusion
study
revealed
plays
crucial
progression
identified
impact
key
osteosarcoma,
provides
novel
insights
into
diagnosis
therapy.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 3, 2025
Background
Colorectal
adenomas,
which
are
precancerous
lesions
that
can
develop
into
colorectal
cancer,
present
a
significant
challenge
due
to
the
lack
of
comprehensive
early
screening
and
clear
identification
risk
factors.
Objectives
We
conduct
double-blind,
prospective
cross-sectional
analysis
examine
relationship
between
lifestyle,
mental
health,
adenomas.
Methods
Between
June
2023
July
2024,
we
surveyed
246
participants
at
Hubei
Provincial
Hospital
Traditional
Chinese
Medicine
in
Wuhan
using
self-administered
online
questionnaire.
Results
The
majority
were
over
age
50
(49.6%),
married
or
living
with
partner
(87.08%),
employed
as
office
workers
technicians
(44.3%).
Among
total
population,
435
individuals
(53.5%)
diagnosed
A
positive
association
was
observed
being
manager
(OR
=
2.340;
95%
CI
1.043–5.248)
presence
well
having
BMI
28
6.000;
1.501–23.991).
After
adjusting
for
professional
role
BMI,
no
associations
found
scores
on
HADS-D
(AOR
1.031;
0.967–1.099)
PSS-10
0.971;
0.923–1.022)
scales
However,
higher
AUDIT
1.001–1.144),
CDS-12
1.028;
1.003–1.054),
PSQI
1.079;
1.003–1.161),
HADS-A
1.156;
1.059–1.262)
significantly
associated
an
increased
likelihood
Conclusion
study
highlights
significance
addressing
alcohol
consumption,
smoking,
sleep
quality,
anxiety
reduce
Targeted
health
interventions
may
play
crucial
alleviating
this
burden
enhancing
overall
population
health.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2872 - 2872
Опубликована: Март 21, 2025
Sleep
is
a
fundamental
process
essential
for
all
organisms.
deprivation
can
lead
to
significant
detrimental
effects,
contributing
various
physiological
disorders
and
elevating
the
risk
of
several
diseases.
Investigating
relationship
between
sleep
human
diseases
offers
valuable
insights
into
molecular
mechanisms
governing
regulation,
potentially
guiding
development
more
effective
treatments
associated
This
study
explored
roles
sleep-related
genes
in
biological
processes
their
associations
with
chronic
diseases,
mainly
including
neurological,
metabolic,
cardiovascular
cancer.
Additionally,
an
analysis
on
was
also
performed
understand
potential
role
tumorigenesis.
review
aims
enhance
understanding
link
novel
therapeutic
approaches
targeting
circadian
rhythm-related
Immunological Reviews,
Год журнала:
2023,
Номер
321(1), С. 169 - 180
Опубликована: Ноя. 10, 2023
Cancer
arises
from
the
growth
and
division
of
uncontrolled
erroneous
cells.
Programmed
cell
death
(PCD),
or
regulated
(RCD),
includes
natural
processes
that
eliminate
damaged
abnormal
Dysregulation
PCD
is
a
hallmark
cancer,
as
cancer
cells
often
evade
continue
to
proliferate.
Exosomes
nanoscale
extracellular
vesicles
secreted
by
different
types
carrying
variety
molecules,
including
nucleic
acids,
proteins,
lipids,
have
indispensable
role
in
communication
between
cells,
can
influence
various
cellular
processes,
PCD.
been
shown
modulate
transferring
pro-
antideath
molecules
neighboring
Additionally,
exosomes
facilitate
spread
surrounding
making
them
promising
treatment
cancers.
The
exosomes'
diagnostic
potential
also
an
active
area
research.
be
isolated
wide
range
bodily
fluids
tissues,
such
blood
urine,
provide
noninvasive
way
monitor
progression
response.
Furthermore,
employed
delivery
system
for
therapeutic
agents.
By
engineering
carry
drugs
other
they
targeted
specifically
reducing
toxicity
healthy
tissues.
Here,
we
discussed
diagnosis
prevention
cancers,
tumor
immunotherapy,
drug
delivery,
well
Obesity Facts,
Год журнала:
2024,
Номер
unknown, С. 1 - 20
Опубликована: Окт. 21, 2024
Obesity,
a
prevalent
and
multifactorial
disease,
is
linked
to
range
of
metabolic
abnormalities,
including
insulin
resistance,
dyslipidemia,
chronic
inflammation.
These
imbalances
not
only
contribute
cardiometabolic
diseases
but
also
play
significant
role
in
cancer
pathogenesis.
The
rising
prevalence
obesity
underscores
the
need
investigate
dietary
strategies
for
effective
weight
management
individuals
with
overweight
or
cancer.
This
European
Society
Study
Obesity
(EASO)
position
statement
aimed
summarize
current
evidence
on
provide
insights
major
nutritional
interventions,
Mediterranean
diet
(MedDiet),
ketogenic
(KD),
intermittent
fasting
(IF),
that
should
be
adopted
manage
MedDiet,
characterized
by
high
consumption
plant-based
foods
moderate
intake
olive
oil,
fish,
nuts,
has
been
associated
reduced
risk.
KD
IF
are
emerging
interventions
potential
benefits
loss
health.
KD,
inducing
ketosis,
IF,
through
periodic
cycles,
may
offer
anticancer
effects
modifying
tumor
metabolism
improving
sensitivity.
Despite
promising
results,
these
approaches
limited
inconsistent,
challenges
variability
adherence
personalized
plans.
European Journal of Cancer Care,
Год журнала:
2024,
Номер
2024, С. 1 - 15
Опубликована: Март 23, 2024
Background.
Circadian
rhythm
disruption
involves
tumorigenesis
and
tumor
progression.
However,
the
influences
of
circadian
on
microenvironment
(TME)
prognosis
hepatocellular
carcinoma
(HCC)
are
unknown.
Methods.
Bulk
RNA-seq
single-cell
from
TCGA,
ICGC,
GEO
were
used
to
comprehensively
identify
prognostic
control
cells
associated
genes
(CRRGs)
using
R
Python
packages.
Besides,
rhythm-related
signature
was
identified
validated.
The
biological
function,
immune
infiltration,
therapeutic
response
with
(CR)
risk
detected.
Results.
A
total
252
differentially
expressed
CRRGs
in
HCC
identified,
a
high
CR
score
revealed
poor
survival.
We
annotated
11
major
cell
types
TME;
(B
cells,
myeloid,
CD4+
CD8+
NK
Tregs)
score,
hepatocyte,
bio-potent
fibroblasts,
endothelial
low
identified.
Moreover,
five
(RPL29,
PFKFB3,
RPS7,
SLC6A6,
RPLP2)
selected
validated
as
HCC.
calculated
based
signature,
patients
then
divided
into
high-risk
low-risk
groups
according
median
value
score.
High
is
linked
several
metabolism-related
pathways
canonical
cancer-related
negatively
immunotherapeutic
responses
positively
some
chemotherapeutic
drugs.
Conclusion.
Our
finding
provides
novel
represents
viable
“time-dependent”
option
for
treatment.
Diabetology & Metabolic Syndrome,
Год журнала:
2024,
Номер
16(1)
Опубликована: Ноя. 10, 2024
We
investigated
the
association
between
sleep
problems
and
cardiometabolic
risks
potential
linking
effect
of
metabolites
metabolic
pathways
based
on
multi-layered
research,
including
observational,
mendelian
randomization
(MR),
metabolomics
analysis.
