FOXM1: a new therapeutic target of extramammary Paget disease DOI Creative Commons
Takamichi Ito, Yuka Tanaka,

Yumiko Kaku‐Ito

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 19, 2024

Abstract Extramammary Paget disease (EMPD) is a rare skin cancer that primarily affects older individuals predominantly in areas with apocrine sweat glands. Although most early EMPD lesions are indolent, patients metastatic have poor prognosis due to the lack of effective systemic treatment. In this study, we investigated role forkhead box M1 (FOXM1), potent transcription factor, and assessed potential FOXM1 as therapeutic target. Immunohistochemistry 112 primary 17 samples revealed expression increased tumor progression. Patients whom was expressed more than 10% cells had significantly shorter disease-specific survival other ( p = 0.0397). vitro studies using our newly established cell line, KS-EMPD-1, found high FOXM1. Knockdown impaired viability, migration, invasion. Inhibition thiostrepton also reduced viability dose-dependent manner. These findings suggest promising target for EMPD.

Язык: Английский

NEK2 promotes the progression of osteosarcoma through the AKT/p-AKT pathway and interacts with FoxM1 DOI

Xin Tan,

X. H. Liang,

Yi Feng

и другие.

Medical Oncology, Год журнала: 2025, Номер 42(4)

Опубликована: Март 19, 2025

Язык: Английский

Процитировано

0
APOC1, transcriptionally regulated by FOXM1, promotes M2 macrophage polarization and cervical cancer progression DOI
Qing Chai, Yan Qi, Xiaoyan Nie

и другие.

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Год журнала: 2025, Номер 830, С. 111904 - 111904

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
A Senescence-Associated Gene Signature for Prognostic Prediction and Therapeutic Targeting in Adrenocortical Carcinoma DOI Creative Commons
Hangya Peng, Qiujing Chen, Lei Ye

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 894 - 894

Опубликована: Апрель 8, 2025

Background/Objectives: Cellular senescence plays a critical role in tumorigenesis, immune cell infiltration, and treatment response. Adrenocortical carcinoma (ACC) is malignant tumor that lacks effective therapies. This study aimed to construct validate senescence-related gene signature as an independent prognostic predictor for ACC explore its impact on the microenvironment, immunotherapy, chemotherapy Methods: Data were collected from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database. Using Kaplan–Meier survival analysis, LASSO penalized Cox regression multivariable regression, we identified model with four genes (HJURP, CDK1, FOXM1, CHEK1). model’s value was validated through risk score curves, receiver operating characteristic (ROC) curves. Tumor mutation burden assessed maftools, microenvironment analyzed using CIBERSORT ESTIMATE. Immune chemotherapeutic responses Dysfunction Exclusion (TIDE) OncoPredict. Results: derived our showed strong association overall (OS) patients (p < 0.001, HR = 2.478). Higher scores correlated more advanced stages greater frequency of somatic mutations. Differentially expressed (DEGs) downregulated high-risk group significantly enriched immune-related pathways. Furthermore, predicted have reduced sensitivity immunotherapy 0.02). Bioinformatics analysis potential agents, including BI-2536 MIM1, options patients. Conclusions: Our findings indicate this may serve valuable tool predicting patients, those receiving immunotherapy.

Язык: Английский

Процитировано

0
Targeting friend leukemia integration 1: A promising approach for prevention and treatment of solid tumors DOI
Moumita Kundu, Ankita Dey, Pradipta Maji

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 309, С. 143080 - 143080

Опубликована: Апрель 12, 2025

Язык: Английский

Процитировано

0
The oncogenic role of FOXM1 in hepatocellular carcinoma: molecular mechanisms, clinical significance, and therapeutic potentials DOI
Fengtian He, He Liu, Fangcheng Zhao

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Overexpression of FOXM1 drives mycosis fungoides progression by regulating the cell cycle DOI
Kecen Liu, Huizhong Wang,

Jingyang Dang

и другие.

Journal of Dermatological Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
FOXM1 could serve as a bridge mediating prognosis and immunity for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing DOI Creative Commons
Jianhua Zhou,

Zheng-fu Xu,

Yang Yu

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 28, 2025

Язык: Английский

Процитировано

0
FOXM1 boosts glycolysis by upregulating SQLE to inhibit anoikis in breast cancer cells DOI Creative Commons

Mei Xu,

Guoyuan Pan, Qian Zhang

и другие.

Journal of Cancer Research and Clinical Oncology, Год журнала: 2025, Номер 151(5)

Опубликована: Май 13, 2025

Resisting anoikis is a prerequisite for cancer to spread and invade major cause of cancer-related deaths. Yet, the intricate mechanisms how cells evade remain largely unknown. There significant need explore these play out in breast (BC). Bioinformatics analysis revealed expression levels SQLE FOXM1 BC tissue, along with their correlation. The enrichment pathways were also explored. qPCR detected cells. CCK-8 assessed cell viability, while flow cytometry measured anoikis. Western blot was employed examine protein key genes glycolytic metabolism apoptosis-related proteins. Extracellular acidification rate quantified, corresponding kits evaluated glucose consumption, lactate production, adenosine triphosphate Dual-luciferase reporter assays chromatin immunoprecipitation tests unveiled binding relationship between SQLE. found be highly expressed enriched associated glycolysis. curbed via aerobic glycolysis pathway. direct positive correlation expression. Recovery experiments substantiated that targeted suppress upregulates SQLE, which turn mediates BC. FOXM1/SQLE axis promising therapeutic target treatment.

Язык: Английский

Процитировано

0
Computed Tomography-Based Radiomics to Predict FOXM1 Expression and Overall Survival in Patients with Clear Cell Renal Cell Carcinoma DOI
Jingwei Zhao, Qi Zhang, Yan Chen

и другие.

Academic Radiology, Год журнала: 2024, Номер 31(9), С. 3635 - 3646

Опубликована: Март 12, 2024

Язык: Английский

Процитировано

3
Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies DOI Creative Commons
Zhengyue Zhang, Yanjie Zhang

Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)

Опубликована: Апрель 2, 2024

Cancer stem cells (CSCs) were first discovered in the 1990s, revealing mysteries of cancer origin, migration, recurrence and drug-resistance from a new perspective. The expression pluripotent genes complex signal regulatory networks are significant features CSC, also act as core factors to affect characteristics CSC. Transcription is necessary link regulate phenotype potential involving chromatin environment, nucleosome occupancy, histone modification, transcription factor (TF) availability cis-regulatory elements, which suffer ambient pressure. Especially, activity TFs deeply affected by both internal external factors, foundation CSC transcriptional regulation current research framework. Growing evidence indicates that regulating epigenetic modifications alter stemness effective, some special promoters enhancers can serve targets influence properties Clarifying will assist us directly target key TFs, or hinder through environmental other related order achieve goal inhibiting tumors. This paper comprehensively reviews traditional aspects regulation, explores progress insights impact on status tumor microenvironment (TME), hypoxia, metabolism meaningful conjunction with latest research. Finally, we present opinions omnidirectional targeting CSCs eliminate address resistance.

Язык: Английский

Процитировано

3