Archives of Pharmaceutical Sciences Ain Shams University,
Год журнала:
2024,
Номер
8(1), С. 133 - 145
Опубликована: Апрель 9, 2024
The
carcinogenesis
process
includes
several
epigenetic
modifications
that
mainly
target
the
silencing
of
tumor
suppressor
genes
(TS
genes)
including
ribonucleic
acid
(RNA)
editing,
deoxyribonucleic
(DNA)
hypermethylation
and
histone
modification,
either
by
methylation
demethylation,
or
acetylation
deacetylation.
Histone
deacetylation
is
one
most
important
responsible
for
cancer
development,
thereby,
design
new
selective
deacetylase
inhibitors
(HDACIs)
a
promising
chemotherapeutic
target.
Up
to
this
time,
all
HDACIs
approved
are
hydroxamic
based.
Yet,
acids
often
show
drawbacks
upon
administration,
such
as
poor
pharmacokinetic
properties,
selectivity,
multiple
toxicities.
That's
why
urge
emersion
category
compounds
was
crucial.
Thereby,
non-hydroxamate
based
attracted
widespread
attention
being
part
biologically
active
safer
alternative
hydroxamate
ones.
In
mini-review,
we
aim
focus
on
HDACIs,
specifically
those
used
anticancer
agents,
concept
behind
their
development.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2479 - 2479
Опубликована: Фев. 20, 2024
The
genes
coding
for
the
tumor
suppressors
p53
and
retinoblastoma
(Rb)
are
inactivated
in
vast
majority
of
small
cell
lung
cancer
(SCLC)
tumors.
Data
support
notion
that
these
two
deleterious
genetic
events
represent
initial
steps
development
SCLC,
making
them
essential
a
epithelial
to
progress
toward
acquisition
malignant
phenotype.
With
loss
TP53
RB1,
their
broad
suppressive
functions
eliminated
normal
is
able
proliferate
indefinitely,
escape
entering
into
cellular
senescence,
evade
death,
no
matter
damage
it
has
experienced.
Within
this
setting,
cells
accumulate
further
oncogenic
mutations
well
on
way
becoming
SCLC
cells.
Understanding
molecular
mechanisms
lesions
effects
within
paramount
importance,
order
tackle
aggressive
deadly
cancer.
present
review
summarizes
current
knowledge
Rb
aberrations,
biological
significance,
prospective
therapeutic
potential,
highlighting
completed
ongoing
clinical
trials
with
agents
target
downstream
pathways.
NAR Genomics and Bioinformatics,
Год журнала:
2025,
Номер
7(1)
Опубликована: Янв. 7, 2025
Abstract
Understanding
the
role
of
transcription
and
factors
(TFs)
in
cellular
identity
disease,
such
as
cancer,
is
essential.
However,
comprehensive
data
resources
for
cell
line-specific
TF-to-target
gene
annotations
are
currently
limited.
To
address
this,
we
employed
a
straightforward
method
to
define
regulons
that
capture
cell-specific
aspects
TF
binding
transcript
expression
levels.
By
integrating
transcriptome
data,
generated
40
common
lines
comprising
both
proximal
distal
regulatory
events.
Through
systematic
benchmarking
involving
knockout
experiments,
demonstrated
performance
on
par
with
state-of-the-art
methods,
our
being
easily
applicable
other
types
interest.
We
present
case
studies
using
three
cancer
single-cell
datasets
showcase
utility
these
cell-type-specific
exploring
transcriptional
dysregulation.
In
summary,
this
study
provides
valuable
pipeline
resource
systematically
regulations,
emphasizing
network
analysis
deciphering
disease
mechanisms.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 27, 2025
Head
and
neck
squamous
cell
carcinoma
(HNSC)
is
a
common
malignant
tumor
with
high
incidence
mortality
rates.
ETS
variant
transcription
factor
4
(ETV4),
an
important
factor,
plays
key
role
in
various
cancers.
However,
the
of
ETV4
HNSC
remains
unclear.
This
study
aimed
to
explore
potential
prognostic
value
oncogenic
effects
HNSC.
We
analyzed
expression
patients'
data
from
TCGA
database,
alongside
clinical
pathological
characteristics.
The
STRING
GEPIA
databases
were
utilized
ETV4's
interaction
proteins
related
genes.
Gene
Set
Enrichment
Analysis
(GSEA)
was
performed
on
stratified
TCGA-HNSC
cohort
based
levels.
correlation
between
immune
cells,
checkpoints,
regulatory
genes
further
using
R
packages
TISIDB
database.
Finally,
knockdown
nasopharyngeal
cells
(NPCs)
siRNA
evaluate
proliferation,
migration,
invasion
CCK-8,
wound
healing,
clone
formation,
Transwell
assays.
significantly
overexpressed
closely
characteristics
prognosis.
GSEA
enrichment
analysis
showed
significant
multiple
suppression
pathways.
Further
immune-related
indicated
that
negatively
correlated
most
tumor-infiltrating
lymphocyte
type
characteristic
molecules,
immunoinhibitors,
activators
MHC
molecules.
Knocking
down
inhibited
migration
NPCs.
may
serve
as
biomarker
immunotherapy
target
High
have
negative
effect
level,
matrix
components
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 807 - 807
Опубликована: Июль 7, 2024
In
mammals,
specificity
protein
1
(SP1)
was
the
first
Cys2-His2
zinc
finger
transcription
factor
to
be
isolated
within
and
Krüppel-like
(Sp/KLF)
gene
family.
SP1
regulates
expression
by
binding
Guanine–Cytosine
(GC)-rich
sequences
on
promoter
regions
of
target
genes,
affecting
various
cellular
processes.
Additionally,
activity
is
markedly
influenced
posttranslational
modifications,
such
as
phosphorylation,
acetylation,
glycosylation,
proteolysis.
implicated
in
regulation
apoptosis,
cell
hypertrophy,
inflammation,
oxidative
stress,
lipid
metabolism,
plaque
stabilization,
endothelial
dysfunction,
fibrosis,
calcification,
other
pathological
These
processes
impact
onset
progression
numerous
cardiovascular
disorders,
including
coronary
heart
disease,
ischemia-reperfusion
injury,
cardiomyopathy,
arrhythmia,
vascular
disease.
emerges
a
potential
for
prevention
therapeutic
intervention
cardiac
ailments.
this
review,
we
delve
into
biological
functions,
pathophysiological
mechanisms,
clinical
implications
pathology
offer
valuable
insights
regulatory
functions
diseases
unveil
novel
avenues
treatment
conditions.
Glioma
remains
one
of
the
most
challenging
brain
tumors
with
poor
prognosis.
In
this
study,
we
aimed
to
elucidate
role
TUBB6
in
glioma
and
its
potential
as
a
diagnostic
prognostic
biomarker.
Analysis
GSE42656
TCGA
datasets
revealed
that
was
significantly
upregulated
tissues
compared
normal
tissues.
The
value
demonstrated
an
area
under
curve
(AUC)
0.702,
suggesting
it
could
be
used
biomarker
differentiate
gliomas
Correlation
analyses
high
expressions
were
associated
advanced
WHO
grades,
IDH
mutation
status,
histological
types
glioma.
Further
investigation
identified
NFKB1
key
transcription
factor
binds
promoter
region
TUBB6,
upregulating
expression
cells.
Elevated
levels
overall
survival
disease-specific
patients.
Knockdown
resulted
reduced
cells,
confirming
regulatory
roles
expression.
Prognostic
analysis
using
CGGA
poorer
(OS)
(DSS)
independent
for
both
OS
DSS.
Additionally,
pan-cancer
dysregulated
various
tumor
showed
across
multiple
cancers.
Functional
enrichment
TUBB6-associated
differentially
expressed
genes
indicated
involvement
immune
response,
extracellular
matrix
remodeling,
cytokine
signaling
pathways.
vitro
experiments
knockdown
suppressed
cell
proliferation
promoted
apoptosis
by
regulating
canonical
Wnt/β-catenin
pathway.
Our
findings
suggest
contributes
malignancy
through
effects
on
conclusion,
emerges
promising
diagnosis
Its
regulation
pathways
underscore
therapeutic
target
treatment.
Lung Cancer,
Год журнала:
2024,
Номер
195, С. 107918 - 107918
Опубликована: Авг. 5, 2024
Tigger
transposable
element-derived
1
(TIGD1)
expression
and
its
underlying
functions
regulatory
mechanisms
in
lung
adenocarcinoma
(LUAD)
remain
unknown.
Therefore,
we
intended
to
explore
the
expression,
potential
functions,
of
TIGD1
LUAD.
