Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes DOI Creative Commons
Luca Pangrazzi, Andreas Meryk

Biology, Год журнала: 2024, Номер 14(1), С. 17 - 17

Опубликована: Дек. 27, 2024

Immunosenescence, the age-related decline in immune function, is a complex biological process with profound implications for health and longevity. This phenomenon, characterized by alterations both innate adaptive immunity, increases susceptibility to infections, reduces vaccine efficacy, contributes development of diseases. At cellular level, immunosenescence manifests as decreased production naive T B cells, accumulation memory senescent thymic involution, dysregulated cytokine production. Recent advances molecular biology have shed light on underlying mechanisms immunosenescence, including telomere attrition, epigenetic alterations, mitochondrial dysfunction, changes key signaling pathways such NF-κB mTOR. These lead functional impairments various cell types, altering their proliferative capacity, differentiation, effector functions. Emerging research suggests that lifestyle factors may modulate rate extent at levels. Physical activity, nutrition, stress management, sleep patterns been shown influence inflammatory markers, oxidative older adults. review provides comprehensive analysis explores how interventions impact these processes. We will examine current understanding genomic, epigenomic, proteomic levels, discuss can potentially mitigate or partially reverse aspects aging. By integrating recent findings from immunology, gerontology, biology, we aim elucidate intricate interplay between aging informing future strategies maintaining competence populations.

Язык: Английский

Fungi, immunosenescence and cancer DOI Creative Commons
Bin Xu,

Zan Luo,

Xing Niu

и другие.

Seminars in Cancer Biology, Год журнала: 2025, Номер 109, С. 67 - 82

Опубликована: Янв. 7, 2025

Язык: Английский

Процитировано

4
Quality control of mitochondrial nucleoids DOI
Hao Liu,

Haixia Zhuang,

Du Feng

и другие.

Trends in Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Activation of pyroptosis and immunogenic cell death by targeted liposomal cisplatin for enhanced chemo-immunotherapy for osteosarcoma DOI

Jingyou Bi,

Yuchen Han,

Xin-Li Han

и другие.

Nano Today, Год журнала: 2025, Номер 62, С. 102717 - 102717

Опубликована: Март 19, 2025

Язык: Английский

Процитировано

0
Cytosolic cytochrome c represses ferroptosis DOI
Xinxin Song, Zhuan Zhou, Jiao Liu

и другие.

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Immunogenic Cell Death and Metabolic Reprogramming in Cancer: Mechanisms, Synergies, and Innovative Therapeutic Strategies DOI Creative Commons
Jie Jiang, Ying Yan, Chunhui Yang

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 950 - 950

Опубликована: Апрель 12, 2025

Immunogenic cell death (ICD) is a promising cancer therapy where dying tumor cells release damage-associated molecular patterns (DAMPs) to activate immune responses. Recent research highlights the critical role of metabolic reprogramming in cells, including Warburg effect, oxidative stress, and lipid metabolism, modulating ICD shaping microenvironment. These changes enhance activation, making tumors more susceptible surveillance. This review explores mechanisms linking mitochondrial endoplasmic reticulum (ER) ferroptosis. It also discusses innovative therapeutic strategies, such as personalized combination therapies, inhibitors, targeted delivery systems, improve efficacy. The future immunotherapy lies integrating activation overcome evasion, with multi-omics approaches microbiome modulation offering new avenues for enhanced treatment outcomes.

Язык: Английский

Процитировано

0
Nanotechnology-Based Strategies for Safe and Effective Immunotherapy DOI Creative Commons
Seungpyo Hong, Juwon Park, Yoo Jin Oh

и другие.

Molecules, Год журнала: 2024, Номер 29(24), С. 5855 - 5855

Опубликована: Дек. 11, 2024

Cancer immunotherapy using immune checkpoint blockades has emerged as a promising therapeutic approach. However, faces challenges such low response rates in solid tumors, necessitating strategies to remodel the immune-suppressive tumor microenvironment (TME) into an immune-activated state. One of primary approaches achieve this transformation is through induction immunogenic cell death (ICD). Herein, we discussed maximize ICD nanoparticles. In particular, review highlighted various studies integrating chemotherapy, radiation therapy (RT), photodynamic (PDT), and photothermal (PTT) with nanoparticle-based immunotherapy. The research covered aims provide valuable insights for future on nanoparticle-assisted

Язык: Английский

Процитировано

1
Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes DOI Creative Commons
Luca Pangrazzi, Andreas Meryk

Biology, Год журнала: 2024, Номер 14(1), С. 17 - 17

Опубликована: Дек. 27, 2024

Immunosenescence, the age-related decline in immune function, is a complex biological process with profound implications for health and longevity. This phenomenon, characterized by alterations both innate adaptive immunity, increases susceptibility to infections, reduces vaccine efficacy, contributes development of diseases. At cellular level, immunosenescence manifests as decreased production naive T B cells, accumulation memory senescent thymic involution, dysregulated cytokine production. Recent advances molecular biology have shed light on underlying mechanisms immunosenescence, including telomere attrition, epigenetic alterations, mitochondrial dysfunction, changes key signaling pathways such NF-κB mTOR. These lead functional impairments various cell types, altering their proliferative capacity, differentiation, effector functions. Emerging research suggests that lifestyle factors may modulate rate extent at levels. Physical activity, nutrition, stress management, sleep patterns been shown influence inflammatory markers, oxidative older adults. review provides comprehensive analysis explores how interventions impact these processes. We will examine current understanding genomic, epigenomic, proteomic levels, discuss can potentially mitigate or partially reverse aspects aging. By integrating recent findings from immunology, gerontology, biology, we aim elucidate intricate interplay between aging informing future strategies maintaining competence populations.

Язык: Английский

Процитировано

1