ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
17(1), С. 867 - 879
Опубликована: Дек. 18, 2024
Enzyme
catalysis
is
a
promising
method
for
producing
chiral
chemicals
with
high
stereoselectivity
under
mild
conditions.
However,
the
traditional
batch
reaction
suffers
from
low
enzyme
stability,
cofactor
recycling,
and
poor
reusability.
Here,
we
present
continuous-flow
using
coimmobilized
dual
enzymes
synthesis
of
γ-/δ-lactones,
which
are
widely
used
in
fragrances
flavors.
Typically,
carbonyl
reductase
mutant
SmCRM5
Serratia
marcescens,
was
by
covalent
binding
BmGDH,
glucose
dehydrogenase
capable
recovering
recycling
NADPH.
After
immobilization,
BmGDH
exhibited
8.9-/8.7-fold
increase
catalytic
efficiency
(kcat/Km)
57-/15-fold
half-life
at
30
°C,
respectively.
We
demonstrated
that
continuous
flow
reactor
showed
higher
rate
space-time
yield
(1586
g·L–1
d–1)
than
free
immobilized
production
(R)-δ-decalactone.
This
can
run
continuously
more
650
h
99%
ee
80%
conversion,
total
volume
exceeds
1500
volumes.
The
robustness
this
system
provides
green
efficient
value-added
chemicals.
Journal of Food Process Engineering,
Год журнала:
2024,
Номер
47(7)
Опубликована: Июль 1, 2024
Abstract
Power
ultrasound
is
a
kind
of
green
and
environmentally
friendly
processing
technology.
Still,
because
its
uneven
distribution
acoustic
pressure
in
the
propagation
medium,
large‐scale
industrial
application
limited.
In
order
to
make
more
effective
use
waves,
this
paper
uses
counter‐current
ultrasound‐assisted
extraction
container
as
geometric
model
simulation,
calculates
field
by
COMSOL
Multiphysics
software,
investigates
effect
on
fluid
field,
temperature
field.
The
simulation
results
showed
that
increased
with
increase
power
frequency,
tended
balance
rise
distance,
cavitation
was
likely
occur.
medium
velocity
vorticity
fluid,
which
conducive
generation
mixing
effects.
Under
pulse
working
mode
for
4
min,
central
axis
stepped
order,
maximum
19.3°C.
We
can
see
establishment
provides
some
theoretical
guidance
practical
food
industry.
Practical
Applications
limitation
mainly
lies
nonuniform
when
propagates
medium.
Therefore,
mastering
multiple
physical
fields
reaction
zone
through
has
important
technical
support
guiding
significance
designing
efficient
equipment
production
ultrasound.
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
103, С. 106781 - 106781
Опубликована: Янв. 24, 2024
Ultrasonic-assisted
activated
carbon
separation
(UACS)
was
first
employed
to
improve
product
quality
by
regulating
adsorption
rate
and
removing
bacterial
endotoxin
from
salvia
miltiorrhizae
injection.
The
related
three
variables:
dosage,
ultrasonic
power,
pH.
With
the
increase
of
dosage
0.05
%
1.0
%,
rates
salvianolic
acids
increased
simultaneously.
at
which
bacteria
endotoxins
52.52
97.16
were
much
higher
than
acids.
As
power
0
700
W,
on
declined
less
10
but
more
87
%.
pH
2.00
8.00,
acid
dropped
whereas
remained
relatively
stable.
On
basis
response
surface
methodology
(RSM),
optimal
conditions
established
be
dose
0.70
600
7.90.
experimental
94.15
satisfied
injection
criterion.
Meanwhile,
acids'
1.92
for
tanshinol,
4.05
protocatechualdehyde,
2.21
rosmarinic
acid,
3.77
B,
all
lower
conventional
(CACA).
Salvianolic
mechanism
is
dependent
component's
molecular
state.
Under
ideal
conditions,
states
four
fall
between
1.13
6.60
can
improved
while
maintaining
safety
reducing
5
use
ultrasound
accelerate
desorption
mass
transfer
surface.
When
used
in
process
producing
injection,
solution
around
5.00,
proportion
each
state
tanshinol
7.05
protocatechualdehyde
48.93
13.79
B
10.28
respectively.
loss
useful
components
evident,
corresponding
ranged
20.74
41.05
average
variation
plasma
His
IgE
significant
(P
<
0.05)
following
0.01
carbon,
however
dramatically
decreased
with
UACS
CACA
>
0.05).
a
intensity
60
W/L
density
1.20
W/cm2
may
resolve
contradiction
endotoxin,
according
experiments
conducted
different
intensities.
According
this
study,
has
lot
potential
applications
pharmaceutical
manufacturing
industry
represent
breakthrough
field
separation.
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
104, С. 106816 - 106816
Опубликована: Фев. 23, 2024
Bubbles
oscillating
in
the
presence
of
ultrasound
is
commonly
employed
biomedical
applications
for
drug
delivery,
enhanced
thrombolysis,
and
transport
manipulation
cells.
This
possible
because
bubbles
tend
to
interact
with
undergo
periodic
shape
changes
known
as
shape-mode
oscillation,
concomitant
generation
liquid
agitation
or
streaming.
phenomenon
examined
both
experimentally
theoretically
on
a
single
bubble
at
frequency
(45
±
1)
kHz.
Effects
ultrasonic
power
flowfield
were
explored.
Experiments
revealed
different
trends
development
streaming
velocities
acoustic
forcing
conditions
(5.53,
6.80
7.02
Vpp),
lowest
(0.5
mm/s)
highest
(1.1
values
time-averaged
mean
velocity
occurring
Vpp
Vpp,
respectively.
Simulations
captured
simultaneous
evolution
bubble-shapes
that
helped
create
flow
vortices
surrounding
bubble.
These
collectively
responsible
generating
signature
patterns
dominant
bubble,
could
also
generate
localised
shear
stresses
practical
application.
The
pressure
profiles
around
confirmed
connection
applied
reflected
soundwaves
driving
this
phenomenon.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(15), С. 17512 - 17523
Опубликована: Июль 26, 2024
Magnetic
nanomaterials
typically
exhibit
good
solid–liquid
separation
properties
and
surface
modifiability,
making
them
widely
used
in
the
purification
of
highly
toxic
pollutants
despite
problem
magnetic
agglomeration.
Herein,
pure
Fe3O4
nanoparticles,
graphene
oxide
(GO)-modified
nanocomposites,
polypyrrole
(PPy)-modified
GO
PPy-comodified
nanocomposites
were
as
adsorbents
to
explore
universal
effective
dispersion
methods
functionalized
nanoadsorbents
from
perspective
acoustic
parameters.
System
tests
have
shown
that
regardless
whether
is
modified
or
not,
ultrasound
radiation
can
significantly
enhance
adsorption
Cr(VI)
(2.1–7.3-folds).
Detailed
performance
tests,
ultrasonic
parameters,
color
development
experiments
show
enhanced
characteristics
with
improved
a
strong
frequency/power
dependence.
Interestingly,
single
modification
layer,
especially
combined
weakens
this
effect.
After
5
cycles,
nanomaterial
still
has
more
than
90%
efficiency,
indicating
nanoadsorbent
cycle
stability.
In
addition,
method
exhibits
excellent
removal
activity
for
other
heavy
metal
ions
(such
Pb2+)
actual
wastewater.
This
work
confirms
ultrasound-assisted
simple,
efficient,
sustainable
way
fully
demonstrate
application
magnetic-based
nanoadsorbents.
