A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19

Pharmaceutics, Год журнала: 2021, Номер 13(11), С. 1759 - 1759

Опубликована: Окт. 21, 2021

In 2019, the world suffered from emergence of COVID-19 infection, one most difficult pandemics in recent history. Millions confirmed deaths this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is last discovered member family Coronaviridae. Various studies shown that natural compounds effective antiviral properties against coronaviruses inhibiting multiple viral targets, including spike proteins and enzymes. review presents classification a detailed explanation SARS-CoV-2 molecular characteristics structure–function relationships. We present all currently available crystal structures different emphasized on structure virus binding modes their ligands. also discusses various therapeutic approaches for treatment vaccinations. addition, we highlight compare existing data about extracted algae, fungi, plants, scorpion venom were used as agents infection. Moreover, discuss repurposing select approved other viruses.

Язык: Английский

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Label free electrochemical DNA biosensor for COVID-19 diagnosis

Talanta, Год журнала: 2022, Номер 253, С. 123992 - 123992

Опубликована: Окт. 8, 2022

Язык: Английский

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COVID‐19: A systematic review and update on prevention, diagnosis, and treatment

MedComm, Год журнала: 2022, Номер 3(1)

Опубликована: Фев. 17, 2022

Abstract Since the rapid onset of COVID‐19 or SARS‐CoV‐2 pandemic in world 2019, extensive studies have been conducted to unveil behavior and emission pattern virus order determine best ways diagnosis thereof formulate effective drugs vaccines combat disease. The emergence novel diagnostic therapeutic techniques considering multiplicity reports from one side contradictions assessments other necessitates instantaneous updates on progress clinical investigations. There is also growing public anxiety time mutation COVID‐19, as reflected considerable mortality transmission, respectively, delta Omicron variants. We comprehensively review summarize different aspects prevention, diagnosis, treatment COVID‐19. First, biological characteristics were explained standpoint. Thereafter, preclinical animal models discussed frame symptoms effects patient with strategies in‐silico/computational biology. Finally, opportunities challenges nanoscience/nanotechnology identification, discussed. This covers almost all SARS‐CoV‐2‐related topics extensively deepen understanding latest achievements (last updated January 11, 2022).

Язык: Английский

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Electrochemical and optical-based systems for SARS-COV-2 and various pathogens assessment

Advances in Natural Sciences Nanoscience and Nanotechnology, Год журнала: 2023, Номер 14(3), С. 033001 - 033001

Опубликована: Авг. 17, 2023

Abstract A critical step in the process for preventing and identifying emergencies relating to health, safety, welfare is testing quick diagnosis of microbial pathogens. Due fast spread waterborne food borne infections society high costs associated with them, pathogen identification has emerged as one most difficult parts water sectors. Since turn century, pathogens have demonstrated enormous epidemiological pandemic potential. The emergence dissemination a novel virus potential endanger livelihoods well-being individuals worldwide. severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) coronavirus propagated almost every country on Earth had considerable negative influence economies communities. Despite improvements techniques viral diseases, all nations must now execute biosensing speedy, sensitive, focused, consistent manner order address pressing global issues. Hence, this review, we critically summarised recent advancement electrochemical well optical biosensors monitoring SARS-COV-2 various Then, began by providing technical overview cutting-edge strategies utilised combat diseases it, including utilisation point-of-care technology (POCT), artificial intelligence (AI), internet medical things (IoMT). This review article explores integration POC, IoMT, AI technologies context personal healthcare, focusing their expedite treatment conditions, ultimately leading improved patient outcomes. Subsequently, notion execution multiplex are presented enhance comprehension detecting multiple analytes. Finally, conclusions future directions been presented.

Язык: Английский

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Reviewing methods of deep learning for diagnosing COVID-19, its variants and synergistic medicine combinations

Computers in Biology and Medicine, Год журнала: 2023, Номер 163, С. 107191 - 107191

Опубликована: Июнь 20, 2023

Язык: Английский

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Silver Nanoparticle Sensor Array for the Detection of SARS-CoV-2

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(8), С. 9136 - 9146

Опубликована: Апрель 15, 2024

We report a silver nanoparticle (AgNP) sensor array to detect SARS-CoV-2 viral particles utilizing five peptide receptors produce colorimetric response. show that the interaction of virus with peptides interferes shift in plasmonic absorbance and hinders formation snowflake-like fractal assemblies between AgNPs bridging peptides. The limit detection water was 500,000 copies/mL. demonstrate capabilities distinguish (Beta, Delta, Omicron variants) from influenza at 99% confidence level through linear discriminant analysis. also able discriminate three out negative exhaled breath condensate samples positive EBC samples.

Язык: Английский

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Natural Bioactive Molecules: An Alternative Approach to the Treatment and Control of COVID-19

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(23), С. 12638 - 12638

Опубликована: Ноя. 23, 2021

Several coronaviruses (CoVs) have been associated with serious health hazards in recent decades, resulting the deaths of thousands around globe. The coronavirus pandemic has emphasized importance discovering novel and effective antiviral medicines as quickly possible to prevent more loss human lives. Positive-sense RNA viruses group spikes protruding from their surfaces an abnormally large genome enclose CoVs. CoVs already related a range respiratory infectious diseases possibly fatal humans, such MERS, SARS, current COVID-19 outbreak. As result, prevention, treatment, medications against (HCoV) is urgently needed. In years, many natural substances discovered variety biological significance, including properties. Throughout this work, we reviewed wide that interrupt life cycles for MERS well potential application treatment COVID-19.

Язык: Английский

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Smart and emerging point of care electrochemical sensors based on nanomaterials for SARS-CoV-2 virus detection: Towards designing a future rapid diagnostic tool

Chemosphere, Год журнала: 2024, Номер 352, С. 141269 - 141269

Опубликована: Янв. 31, 2024

Язык: Английский

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Photoluminescence-based biosensor for the detection of antibodies against SARS-CoV-2 virus proteins by ZnO tetrapod structure integrated within microfluidic system

The Science of The Total Environment, Год журнала: 2024, Номер 939, С. 173333 - 173333

Опубликована: Май 17, 2024

Язык: Английский

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A CRISPR/Cas13a-powered catalytic hairpin assembly evanescent wave fluorescence biosensor for target amplification-free SARS-CoV-2 detection

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 405, С. 135296 - 135296

Опубликована: Янв. 10, 2024

Язык: Английский

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