Digital and AI-Enhanced Cognitive Behavioral Therapy for Insomnia: Neurocognitive Mechanisms and Clinical Outcomes

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2265 - 2265

Опубликована: Март 26, 2025

Background/Objectives: This systematic review explores the integration of digital and AI-enhanced cognitive behavioral therapy (CBT) for insomnia, focusing on underlying neurocognitive mechanisms associated clinical outcomes. Insomnia significantly impairs functioning, overall health, quality life. Although traditional CBT has demonstrated efficacy, its scalability ability to deliver individualized care remain limited. Emerging AI-driven interventions-including chatbots, mobile applications, web-based platforms-present innovative avenues delivering more accessible personalized insomnia treatments. Methods: Following PRISMA guidelines, this synthesized findings from 78 studies published between 2004 2024. A search was conducted across PubMed, Scopus, Web Science, PsycINFO. Studies were included based predefined criteria prioritizing randomized controlled trials (RCTs) high-quality empirical research that evaluated AI-augmented interventions targeting sleep disorders, particularly insomnia. Results: The suggest improves parameters, patient adherence, satisfaction, personalization in alignment with individual profiles. Moreover, these technologies address critical limitations conventional CBT, notably those related access scalability. AI-based tools appear especially promising optimizing treatment delivery adapting cognitive-behavioral patterns. Conclusions: While demonstrates strong potential advancing through broader accessibility, several challenges persist. These include uncertainties surrounding long-term practical implementation barriers, ethical considerations. Future large-scale longitudinal is necessary confirm sustained benefits AI-powered

Язык: Английский

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Understanding the Impact of the COVID-19 Pandemic, Lockdowns and Social Isolation on Sleep Quality

Nature and Science of Sleep, Год журнала: 2021, Номер Volume 13, С. 2053 - 2064

Опубликована: Ноя. 1, 2021

Abstract: The uncertain, ever-changing and an ongoing nature of the COVID-19 pandemic means that it may take some time before we can fully appreciate negative effect lockdown on our sleep mental health. It is increasingly recognised in aftermath pandemic, several persistent sleep, neuropsychiatric physical sequelae continue long after over. A body evidence to date also highlights a significant disparity health difficulties specific vulnerable groups community, with different temporal profiles issues are reported. In this perspective, argue for possible mechanistic impact its imposed restrictions social isolation quality. We similarly discuss potential international differences, as well similarities, behind reported idiosyncratic biological vulnerabilities have contributed genesis issues. Lastly, propose implementations innovations be needed restructuring disorders services order benefit recovering patients. Keywords: insomnia, hypersomnia, lockdown,

Язык: Английский

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Sleep Dysfunction in COVID-19 Patients: Prevalence, Risk Factors, Mechanisms, and Management

Journal of Personalized Medicine, Год журнала: 2021, Номер 11(11), С. 1203 - 1203

Опубликована: Ноя. 14, 2021

During the COVID-19 pandemic, need to establish prevalence of sleep dysfunction and psychological distress, identify predisposing protective factors, explore effective management strategies remains an important priority. Evidence date suggests that a considerable proportion patients experience significant disturbances (estimated afflict up 50–75%) as well distress such depression, anxiety, traumatic stress. Duration hospitalization, pre-existing mental health concerns, lower absolute lymphocyte count, increased neutrophil-to-lymphocyte ratio have been all associated with greater risk in infected hospitalized patients. Furthermore, this review, we discuss link between deprivation, susceptibility viral infections, psychosocial wellbeing relevance summarize existing evidence regarding presence role apnea individuals. Finally, highlight importance suitable interventions order prevent manage avoid long-term physical implications. Future research should aim provide high-quality information including high risk, underserved, or difficult reach populations on consequences effectiveness applied interventions.

Язык: Английский

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COVID-19 and Sleep Disturbances: A Literature Review of Clinical Evidence

Medicina, Год журнала: 2023, Номер 59(5), С. 818 - 818

Опубликована: Апрель 22, 2023

The need for adequate good quality sleep to optimally function is well known. Over years, various physical, psychological, biological, and social factors have been investigated understand their impact on sleep. However, understanding the etiological processes that are involved in causing disturbances (SD) as impacted by stressful phases such pandemics has not studied. Many management strategies surfaced during latest “coronavirus disease of 2019 (COVID-19) pandemic. occurrence these SD infected uninfected individuals poses a investigate linked this phase. Some include practices distancing, masking, vaccines, medications availability, changes routines, lifestyles. As status infection improved, collective term all prolonged effects COVID-19 after resolution primary called post-COVID-19 syndrome (PCS) surfaced. Apart from impacting infectious phase, aftereffects virus left an even greater PCS. Various mechanisms hypothesized be PCS, but available data inconclusive. Further, varied patterns incidence SDs differed many factors, age, gender, geographical location, making clinical more challenging. This review elucidates coronavirus 2 (SARS-CoV-2) (COVID) health We also different causal relationships, strategies, knowledge gaps related

Язык: Английский

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Comparative Effectiveness of Digital Cognitive Behavioral Therapy vs Medication Therapy Among Patients With Insomnia

JAMA Network Open, Год журнала: 2023, Номер 6(4), С. e237597 - e237597

Опубликована: Апрель 11, 2023

Importance Although digital cognitive behavioral therapy for insomnia (dCBT-I) has been studied in many randomized clinical trials and is recommended as a first-line treatment option, few studies have systematically examined its effectiveness, engagement, durability, adaptability settings. Objective To evaluate the of dCBT-I. Design, Setting, Participants This retrospective cohort study was conducted using longitudinal data collected via mobile app named Good Sleep 365 between November 14, 2018, February 28, 2022. Three therapeutic modes (ie, dCBT-I, medication, their combination) were compared at month 1, 3, 6 (primary). Inverse probability weighting (IPTW) propensity scores applied to enable homogeneous comparisons 3 groups. Exposures Treatment with medication therapy, or combination according prescriptions. Main Outcomes Measures The Pittsburgh Quality Index (PSQI) score essential subitems used primary outcomes. Effectiveness on comorbid somnolence, anxiety, depression, somatic symptoms secondary Cohen d effect size, P value, standardized mean difference (SMD) measure differences Changes outcomes response rates (≥3 points change PSQI score) also reported. Results A total 4052 patients (mean [SD] age, 44.29 [12.01] years; 3028 [74.7%] female participants) selected dCBT-I (n = 418), 862), 2772). Compared months participants receiving alone (from 12.85 [3.49] 8.92 [4.03]), both 13.51 [3.03] 7.15 [3.25]; , −0.50; 95% CI, −0.62 −0.38; < .001; SMD 0.484) 12.92 6.98 [3.43]; 0.50; 0.42 0.58; 0.518) associated significant reductions; had comparable (Cohen 0.05; −0.05 0.15; .66; 0.05), but showed unstable durability. improved steadily rapidly during first months, then fluctuated. higher than medication. indicated statistically benefits from therapy. results subgroup analysis consistent main findings, demonstrating superiority vs various subpopulations. Conclusions Relevance In this study, evidence suggested that optimal, more effective long-term insomnia. Future are needed analyze effectiveness reliability distinct

Язык: Английский

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The Positive Effects of Poria cocos Extract on Quality of Sleep in Insomnia Rat Models

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(11), С. 6629 - 6629

Опубликована: Май 29, 2022

Sleep disorders may have various causes and can incur mental and/or physical symptoms, affect an individual’s quality of life. In this study, we confirm that the Poria cocos extract (PCET) improve sleep structure by promoting inhibitory neurotransmission via γ-aminobutyric acid (GABA) type A (GABAA) receptors based on mechanisms revealed in experiment with superior cervical ganglion neurons. Pentobarbital-induced tests were conducted order to determine whether PCET improves normal ICR mice. latency duration checked righting reflex. To simulate state awakening as well a state, caffeine was administered orally before diet. After oral gavage PCET, decreased, total increased caffeine-induced disturbance state. ACTH-induced disturbed models, administration significantly reduced non-REM duration, which analyzed real-time EEG implanting wireless electrodes SD rats. found under through GABAA receptor; it also promoted improved both arousal activation stress-based disturbance.

Язык: Английский

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Growth in the development of health and fitness mobile apps amid COVID-19 pandemic

Digital Health, Год журнала: 2022, Номер 8, С. 205520762211290 - 205520762211290

Опубликована: Янв. 1, 2022

Objectives Technology in the form of mobile apps has played an essential role facilitating, tracking, and maintaining health fitness activities during pandemic. When countries opted for partial or complete lockdowns to contain spread coronavirus disease 2019 virus, it led people working on their fitness-related from homes, just as they continued home. This paper aims quantify impact development apps. Specifically, we compute effect growth different sub-categories Methods We scraped data about a population 78,890 iOS App Store. First, categories are identified using text analysis descriptions Second, rise new is analyzed. To apps, multiple time-series forecasting models created Results The twelve types app market. Our estimated that number market exceeded expected by 29.9% after results all discussed paper. Conclusions found significant pandemic outbreak. post hoc study presented current state this particular area In addition, provided potential areas markets where there fewer

Язык: Английский

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Stress and the hypothalamic–pituitary–adrenal axis: How can the COVID‐19 pandemic inform our understanding and treatment of acute insomnia?

Journal of Sleep Research, Год журнала: 2023, Номер 32(4)

Опубликована: Фев. 7, 2023

Summary Stress and sleep are very closely linked, stressful life events can trigger acute insomnia. The ongoing COVID‐19 pandemic is highly likely to represent one such event. Indeed, a wide range of cross‐sectional studies demonstrate that the associated with poor disturbances. Given high economic health burden insomnia disorder, strategies prevent treat insomnia, also transition from necessary. This narrative review outlines why event, activation hypothalamic–pituitary–adrenal axis, as biological marker psychological stress, result in Further, this how disturbances might arise pandemic, simultaneous axis measurement inform pathogenesis In particular, we focus on cortisol awakening response function, end‐product axis. From research perspective, future opportunities include identifying individuals, or particular occupational societal groups (e.g. frontline staff), who at risk developing intervening. an treatment priorities testing large‐scale online behavioural interventions; examining if reducing impact stress effective and, finally, assessing whether “sleep vaccination” maintain good by preventing occurrence disorder.

Язык: Английский

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Sleep disturbance increases the risk of severity and acquisition of COVID-19: a systematic review and meta-analysis

European journal of medical research, Год журнала: 2023, Номер 28(1)

Опубликована: Окт. 18, 2023

Abstract Background Understanding the association between sleep quality and COVID-19 outcomes is crucial for effective preventive strategies patient management. This systematic review aims to evaluate impact of as a risk factor acquiring infection severity disease. Methods A comprehensive search electronic databases was conducted identify relevant studies published from inception pandemic which 31 st December 2019 until 30 April 2023. Studies investigating relationship infection, or disease were included. Random effect meta-analysis performed with odds ratios (OR) their 95% confidence intervals (95% CI) measures. Results Out initial 1,132 articles identified, 12 met inclusion criteria. All observational (cohort, case–control, cross-sectional). The examined in 6 studies, results our showed that participants poor 16% increase regarding acquisition (OR 1.16; CI 1.03, 1.32; I 2 = 65.2%, p 0.02). Our 51% incidence primary composite outcome 1.51; 1.25, 1.81; 57.85%, < 0.001). result subgroup analysis also significantly increased mortality (RR 0.67; 0.50, 0.90; 31%, 0.008), 1.47; 1.19, 1.80; 3.21%, 0.001) when comparing group those good quality. Conclusion study highlights significant an well worse clinical outcomes.

Язык: Английский

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Neuropsychiatric Manifestations of Long COVID-19: A Narrative Review of Clinical Aspects and Therapeutic Approaches

Life, Год журнала: 2025, Номер 15(3), С. 439 - 439

Опубликована: Март 11, 2025

The COVID-19 (C-19) pandemic has highlighted the significance of understanding long-term effects this disease on quality life those infected. Long (L-C19) presents as persistent symptoms that continue beyond main illness period, usually lasting weeks to years. One lesser-known but significant aspects L-C19 is its impact neuropsychiatric manifestations, which can have a profound effect an individual’s life. Research shows creates issues such mental fog, emotional problems, and brain symptoms, along with sleep changes, extreme fatigue, severe head pain, tremors seizures, pain in nerves. People cognitive problems plus fatigue mood disorders experience great difficulty handling everyday activities, personal hygiene, social interactions. Neuropsychiatric make people withdraw from activity hurt relationships, thus causing feelings loneliness. unpredictable state generates heavy psychological pressure through suffering, including depression anxiety. changes impairment, swings it hard for work or study effectively, decreases their output at school lowers job contentment. purpose narrative review summarize clinical data present literature regarding manifestations L-C19, identify current methods diagnosis treatment lead correct management condition, highlight these patients’

Язык: Английский

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