medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 4, 2024
Abstract
Research
into
magnetic
resonance
imaging
(MRI)-
visible
perivascular
spaces
(PVS)
has
recently
increased,
as
results
from
studies
in
different
diseases
and
populations
are
cementing
their
association
with
sleep,
disease
phenotypes,
overall
health
indicators.
With
the
establishment
of
worldwide
consortia
availability
large
databases,
computational
methods
that
allow
to
automatically
process
all
this
wealth
information
becoming
increasingly
relevant.
Several
approaches
have
been
proposed
assess
PVS
MRI,
efforts
made
summarise
appraise
most
widely
applied
ones.
We
systematically
reviewed
meta-analysed
publications
available
up
September
2023
describing
development,
improvement,
or
application
quantification
MRI.
analysed
67
60
applications
implementation,
112
publications.
The
two
were
use
a
morphological
filter
enhance
PVS-like
structures,
Frangi
being
choice
preferred
by
most,
U-Net
configuration
without
residual
connections.
Older
adults
population
comprising
18
years
old
onwards
were,
overall,
more
frequent
than
using
clinical
samples.
mainly
assessed
T2-weighted
MRI
acquired
1.5T
and/or
3T
scanners,
although
combinations
it
T1-weighted
FLAIR
images
also
abundant.
Common
associations
researched
included
age,
sex,
hypertension,
diabetes,
white
matter
hyperintensities,
sleep
cognition,
occupation-related,
ethnicity,
genetic/hereditable
traits
explored.
Despite
promising
improvements
overcome
barriers
such
noise
differentiation
other
confounds,
need
for
joined
wider
testing
increasing
is
now
paramount.
NeuroImage,
Год журнала:
2024,
Номер
297, С. 120685 - 120685
Опубликована: Июнь 22, 2024
Research
into
magnetic
resonance
imaging
(MRI)-visible
perivascular
spaces
(PVS)
has
recently
increased,
as
results
from
studies
in
different
diseases
and
populations
are
cementing
their
association
with
sleep,
disease
phenotypes,
overall
health
indicators.
With
the
establishment
of
worldwide
consortia
availability
large
databases,
computational
methods
that
allow
to
automatically
process
all
this
wealth
information
becoming
increasingly
relevant.
Several
approaches
have
been
proposed
assess
PVS
MRI,
efforts
made
summarise
appraise
most
widely
applied
ones.
We
systematically
reviewed
meta-analysed
publications
available
up
September
2023
describing
development,
improvement,
or
application
quantification
MRI.
analysed
67
60
applications
implementation,
112
publications.
The
two
were
use
a
morphological
filter
enhance
PVS-like
structures,
Frangi
being
choice
preferred
by
most,
U-Net
configuration
without
residual
connections.
Older
adults
population
comprising
18
years
old
onwards
were,
overall,
more
frequent
than
using
clinical
samples.
mainly
assessed
T2-weighted
MRI
acquired
1.5T
and/or
3T
scanners,
although
combinations
it
T1-weighted
FLAIR
images
also
abundant.
Common
associations
researched
included
age,
sex,
hypertension,
diabetes,
white
matter
hyperintensities,
sleep
cognition,
occupation-related,
ethnicity,
genetic/hereditable
traits
explored.
Despite
promising
improvements
overcome
barriers
such
noise
differentiation
other
confounds,
need
for
joined
wider
testing
increasing
is
now
paramount.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 7, 2024
Introduction
Traumatic
brain
injury
(TBI)
even
in
the
mild
form
may
result
long-lasting
post-concussion
symptoms.
TBI
is
also
a
known
risk
to
late-life
neurodegeneration.
Recent
studies
suggest
that
dysfunction
glymphatic
system,
responsible
for
clearing
protein
waste
from
brain,
play
pivotal
role
development
of
dementia
following
TBI.
Given
diverse
nature
TBI,
longitudinal
investigations
are
essential
comprehending
dynamic
changes
system
and
its
implications
recovery.
Methods
In
this
prospective
study,
we
evaluated
two
promising
imaging
markers,
namely
enlarged
perivascular
space
(ePVS)
burden
Diffusion
Tensor
Imaging-based
ALPS
index,
44
patients
with
mTBI
at
early
post-injury
time
points:
approximately
14
days
(14Day)
6–12
months
(6–12Mon)
post-injury,
while
examining
their
associations
Additionally,
37
controls,
comprising
both
orthopedic
healthy
individuals,
were
included
comparative
analysis.
Results
Our
key
findings
include:
(1)
White
matter
ePVS
(WM-ePVS)
index
exhibit
significant
correlations
age.
(2)
Elevated
WM-ePVS
acute
significantly
linked
higher
number
symptoms,
particularly
memory
problems.
(3)
The
increase
chronic
phases
correlates
improvement
sleep
measures.
Furthermore,
incorporating
phase
enhances
prediction
problems
beyond
socio-demographic
basic
clinical
information.
Conclusion
offers
distinct
values
assessing
structure
activity.
Early
evaluation
function
could
be
crucial
understanding
recovery
developing
targeted
interventions
improve
patient
outcomes.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 2, 2024
Traumatic
brain
injury
(TBI)
even
in
the
mild
form
may
result
long-lasting
post-concussion
symptoms.
TBI
is
also
a
known
risk
to
late-life
neurodegeneration.
Recent
studies
suggest
that
dysfunction
glymphatic
system,
responsible
for
clearing
protein
waste
from
brain,
play
pivotal
role
development
of
dementia
following
TBI.
Given
diverse
nature
TBI,
longitudinal
investigations
are
essential
comprehending
dynamic
changes
system
and
its
implications
recovery.
In
this
prospective
study,
we
evaluated
two
promising
imaging
markers,
namely
enlarged
perivascular
space
(ePVS)
burden
Diffusion
Tensor
Imaging-based
ALPS
index,
44
patients
with
mTBI
at
early
post-injury
time
points:
approximately
14
days
(14Day)
6-12
months
(6-12Mon)
post-injury,
while
examining
their
associations
Additionally,
37
controls,
comprising
both
orthopedic
healthy
individuals,
were
included
comparative
analysis.
Our
key
findings
include:
1)
White
matter
ePVS
(WM-ePVS)
index
exhibit
significant
correlations
age.
2)
Elevated
WM-ePVS
acute
significantly
linked
higher
number
symptoms,
particularly
memory
problems.
3)
The
increase
chronic
phases
correlates
improvement
sleep
measures.
Furthermore,
incorporating
phase
enhances
prediction
problems
beyond
socio-demographic
basic
clinical
information,
highlighting
distinct
roles
assessing
structure
activity.
Early
evaluation
function
could
be
crucial
understanding
recovery
developing
targeted
interventions
improve
patient
outcomes.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 19, 2024
ABSTRACT
Background
and
Purpose
An
association
recently
emerged
between
magnetic
resonance
imaging
(MRI)-visible
perivascular
spaces
(MV-PVS)
with
intracerebral
solute
clearance
neuroinflammation,
in
adults.
However,
it
is
unknown
how
MV-PVS
change
throughout
adolescence
what
factors
influence
volume
morphology.
This
study
assesses
the
temporal
evolution
of
adolescents
young
adults,
secondarily
evaluates
relationship
MV-PVS,
age,
sex,
body
mass
index
(BMI).
Materials
Methods
analysis
included
a
783
participant
cohort
from
longitudinal
multicenter
National
Consortium
on
Alcohol
Neurodevelopment
Adolescence
that
involved
up
to
6
visits
spanning
5
years.
Healthy
aged
12-21
years
at
entry
least
two
MRI
scans
were
included.
The
primary
outcome
was
mean
(mm
3
/white
matter
cm
).
Results
On
average,
males
had
greater
all
ages
compared
females.
A
linear
mixed-effect
model
for
performed.
Mean
BMI
increases
person’s
associated
over
time.
In
females
only,
changes
correlated
volume.
One
unit
increase
above
average
0.021
mm
/cm
(p<0.001).
Conclusion
showed
sex
differences
features
during
adulthood.
Importantly,
we
report
are
only.
These
findings
suggest
potential
link
warrants
future
study.
Journal of Cardiovascular Development and Disease,
Год журнала:
2024,
Номер
11(11), С. 345 - 345
Опубликована: Ноя. 1, 2024
:
Perivascular
spaces
(PVS)
are
usually
enlarged
in
small
vessel
disease
(SVD).
However,
the
significance
of
PVS
patterns
different
locations
is
uncertain.
Hence,
we
analyzed
distribution
patients
with
a
recent
subcortical
infarct
(RSSI)
and
their
correlation
clinical
imaging
factors.
The
development
of
Alzheimer’s
disease
(AD)
is
closely
associated
with
the
integrity
and
function
perivascular
space
(PVS).
PVS
has
essential
roles
in
transporting
cerebrospinal
fluid
exchanging
intracellular
substances
necessary
to
clear
metabolic
waste
from
brain.
An
enlarged
(ePVS)
now
acknowledged
as
a
major
factor
AD
development,
thus
indicating
complex
interplay
other
pathogenic
factors.
Herein,
we
present
detailed
examination
imaging
features
PVS,
depicted
by
various
MRI
modalities,
highlighting
how
these
techniques
have
advanced
understanding
pathogenesis.
Furthermore,
critically
assess
strengths
limitations
approaches
discuss
prospective
enhancements
that
may
provide
refined
insights.
Further
reveal
new
diagnostic
biomarkers
inform
targeted
therapeutic
approaches,
improving
clinical
management
for
patients
AD.
Abstract
Increased
waste
clearance
in
the
brain
is
thought
to
occur
most
readily
during
late-stage
sleep
(stage
N3).
Sleep
deprivation
disrupts
time
spent
deeper
stages,
fragmenting
process.
Here,
we
have
utilized
publicly
available
Stockholm
Sleepy
Brain
Study
investigate
whether
various
sleep-related
measures
are
associated
with
changes
perivascular
space
(PVS)
volume
fraction
following
a
late-night
short-sleep
experiment.
Our
sample
consisted
of
60
participants
divided
into
old
(65-75
years)
and
young
(20-30
age
groups.
We
found
that
partial
was
not
significantly
major
PVS
changes.
In
centrum
semiovale,
observed
an
interaction
between
percentage
total
N3
status
on
fraction.
basal
ganglia,
saw
N2
(both
absolute
minutes)
status.
However,
significance
these
findings
did
survive
multiple
comparisons
corrections.
This
work
highlights
need
for
future
longitudinal
studies
sleep,
allowing
quantification
within-subject
morphological
occurring
due
patterns
poor
sleep.
here
provide
insight
impacts
single
night
has
system.
Statement
Significance
issues
been
known
be
variety
health
risks.
Recent
research
shown
importance
clearance,
increases
seen
MRI
represent
both
influx
efflux
pathways
exchange
cerebrospinal
fluid
(CSF)
interstitial
(ISF)
parenchyma,
key
process
underlying
1
Numerous
recent
links
disruption
no
study
date
able
examine
resulting
from
experimental
manipulation
represents
first
looking
at
effects
using
automated
segmentation
technique.