A Systematic Review and Meta-Analysis of Automated Methods for Quantifying Enlarged Perivascular Spaces in the Brain DOI Creative Commons
Jennifer M.J. Waymont, María Valdés Hernández, José Bernal

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 4, 2024

Abstract Research into magnetic resonance imaging (MRI)- visible perivascular spaces (PVS) has recently increased, as results from studies in different diseases and populations are cementing their association with sleep, disease phenotypes, overall health indicators. With the establishment of worldwide consortia availability large databases, computational methods that allow to automatically process all this wealth information becoming increasingly relevant. Several approaches have been proposed assess PVS MRI, efforts made summarise appraise most widely applied ones. We systematically reviewed meta-analysed publications available up September 2023 describing development, improvement, or application quantification MRI. analysed 67 60 applications implementation, 112 publications. The two were use a morphological filter enhance PVS-like structures, Frangi being choice preferred by most, U-Net configuration without residual connections. Older adults population comprising 18 years old onwards were, overall, more frequent than using clinical samples. mainly assessed T2-weighted MRI acquired 1.5T and/or 3T scanners, although combinations it T1-weighted FLAIR images also abundant. Common associations researched included age, sex, hypertension, diabetes, white matter hyperintensities, sleep cognition, occupation-related, ethnicity, genetic/hereditable traits explored. Despite promising improvements overcome barriers such noise differentiation other confounds, need for joined wider testing increasing is now paramount.

Язык: Английский

Systematic review and meta-analysis of automated methods for quantifying enlarged perivascular spaces in the brain DOI Creative Commons
Jennifer M.J. Waymont, María Valdés Hernández, José Bernal

и другие.

NeuroImage, Год журнала: 2024, Номер 297, С. 120685 - 120685

Опубликована: Июнь 22, 2024

Research into magnetic resonance imaging (MRI)-visible perivascular spaces (PVS) has recently increased, as results from studies in different diseases and populations are cementing their association with sleep, disease phenotypes, overall health indicators. With the establishment of worldwide consortia availability large databases, computational methods that allow to automatically process all this wealth information becoming increasingly relevant. Several approaches have been proposed assess PVS MRI, efforts made summarise appraise most widely applied ones. We systematically reviewed meta-analysed publications available up September 2023 describing development, improvement, or application quantification MRI. analysed 67 60 applications implementation, 112 publications. The two were use a morphological filter enhance PVS-like structures, Frangi being choice preferred by most, U-Net configuration without residual connections. Older adults population comprising 18 years old onwards were, overall, more frequent than using clinical samples. mainly assessed T2-weighted MRI acquired 1.5T and/or 3T scanners, although combinations it T1-weighted FLAIR images also abundant. Common associations researched included age, sex, hypertension, diabetes, white matter hyperintensities, sleep cognition, occupation-related, ethnicity, genetic/hereditable traits explored. Despite promising improvements overcome barriers such noise differentiation other confounds, need for joined wider testing increasing is now paramount.

Язык: Английский

Процитировано

11
Effects of one-night partial sleep deprivation on perivascular space volume fraction: Findings from the Stockholm Sleepy Brain Study DOI Creative Commons
Rachel M. Custer, Kirsten M. Lynch, Giuseppe Barisano

и другие.

Sleep Medicine, Год журнала: 2025, Номер 131, С. 106537 - 106537

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Longitudinal assessment of glymphatic changes following mild traumatic brain injury: Insights from perivascular space burden and DTI-ALPS imaging DOI Creative Commons
Jiachen Zhuo, Prashant Raghavan, Jiang Li

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Авг. 7, 2024

Introduction Traumatic brain injury (TBI) even in the mild form may result long-lasting post-concussion symptoms. TBI is also a known risk to late-life neurodegeneration. Recent studies suggest that dysfunction glymphatic system, responsible for clearing protein waste from brain, play pivotal role development of dementia following TBI. Given diverse nature TBI, longitudinal investigations are essential comprehending dynamic changes system and its implications recovery. Methods In this prospective study, we evaluated two promising imaging markers, namely enlarged perivascular space (ePVS) burden Diffusion Tensor Imaging-based ALPS index, 44 patients with mTBI at early post-injury time points: approximately 14 days (14Day) 6–12 months (6–12Mon) post-injury, while examining their associations Additionally, 37 controls, comprising both orthopedic healthy individuals, were included comparative analysis. Results Our key findings include: (1) White matter ePVS (WM-ePVS) index exhibit significant correlations age. (2) Elevated WM-ePVS acute significantly linked higher number symptoms, particularly memory problems. (3) The increase chronic phases correlates improvement sleep measures. Furthermore, incorporating phase enhances prediction problems beyond socio-demographic basic clinical information. Conclusion offers distinct values assessing structure activity. Early evaluation function could be crucial understanding recovery developing targeted interventions improve patient outcomes.

Язык: Английский

Процитировано

3
Longitudinal Assessment of Glymphatic Changes Following Mild Traumatic Brain Injury: Insights from PVS burden and DTI-ALPS Imaging DOI Creative Commons
Jiachen Zhuo, Prashant Raghavan, Jiang Li

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 2, 2024

Traumatic brain injury (TBI) even in the mild form may result long-lasting post-concussion symptoms. TBI is also a known risk to late-life neurodegeneration. Recent studies suggest that dysfunction glymphatic system, responsible for clearing protein waste from brain, play pivotal role development of dementia following TBI. Given diverse nature TBI, longitudinal investigations are essential comprehending dynamic changes system and its implications recovery. In this prospective study, we evaluated two promising imaging markers, namely enlarged perivascular space (ePVS) burden Diffusion Tensor Imaging-based ALPS index, 44 patients with mTBI at early post-injury time points: approximately 14 days (14Day) 6-12 months (6-12Mon) post-injury, while examining their associations Additionally, 37 controls, comprising both orthopedic healthy individuals, were included comparative analysis. Our key findings include: 1) White matter ePVS (WM-ePVS) index exhibit significant correlations age. 2) Elevated WM-ePVS acute significantly linked higher number symptoms, particularly memory problems. 3) The increase chronic phases correlates improvement sleep measures. Furthermore, incorporating phase enhances prediction problems beyond socio-demographic basic clinical information, highlighting distinct roles assessing structure activity. Early evaluation function could be crucial understanding recovery developing targeted interventions improve patient outcomes.

Язык: Английский

Процитировано

2
Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces DOI Open Access
Erin Yamamoto, Seiji Koike,

Caitlyn E. Wong

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 19, 2024

ABSTRACT Background and Purpose An association recently emerged between magnetic resonance imaging (MRI)-visible perivascular spaces (MV-PVS) with intracerebral solute clearance neuroinflammation, in adults. However, it is unknown how MV-PVS change throughout adolescence what factors influence volume morphology. This study assesses the temporal evolution of adolescents young adults, secondarily evaluates relationship MV-PVS, age, sex, body mass index (BMI). Materials Methods analysis included a 783 participant cohort from longitudinal multicenter National Consortium on Alcohol Neurodevelopment Adolescence that involved up to 6 visits spanning 5 years. Healthy aged 12-21 years at entry least two MRI scans were included. The primary outcome was mean (mm 3 /white matter cm ). Results On average, males had greater all ages compared females. A linear mixed-effect model for performed. Mean BMI increases person’s associated over time. In females only, changes correlated volume. One unit increase above average 0.021 mm /cm (p<0.001). Conclusion showed sex differences features during adulthood. Importantly, we report are only. These findings suggest potential link warrants future study.

Язык: Английский

Процитировано

1
Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct DOI Creative Commons
C. Sozzi,

Carla Brenlla,

Inés Bartolomé

и другие.

Journal of Cardiovascular Development and Disease, Год журнала: 2024, Номер 11(11), С. 345 - 345

Опубликована: Ноя. 1, 2024

: Perivascular spaces (PVS) are usually enlarged in small vessel disease (SVD). However, the significance of PVS patterns different locations is uncertain. Hence, we analyzed distribution patients with a recent subcortical infarct (RSSI) and their correlation clinical imaging factors.

Язык: Английский

Процитировано

1
Imaging of enlarged perivascular spaces in Alzheimer’s disease with MRI techniques DOI

Wanyin Ma,

Xinxin Wang,

Renhua Wu

и другие.

Radiology Science, Год журнала: 2024, Номер 3(1)

Опубликована: Янв. 1, 2024

The development of Alzheimer’s disease (AD) is closely associated with the integrity and function perivascular space (PVS). PVS has essential roles in transporting cerebrospinal fluid exchanging intracellular substances necessary to clear metabolic waste from brain. An enlarged (ePVS) now acknowledged as a major factor AD development, thus indicating complex interplay other pathogenic factors. Herein, we present detailed examination imaging features PVS, depicted by various MRI modalities, highlighting how these techniques have advanced understanding pathogenesis. Furthermore, critically assess strengths limitations approaches discuss prospective enhancements that may provide refined insights. Further reveal new diagnostic biomarkers inform targeted therapeutic approaches, improving clinical management for patients AD.

Язык: Английский

Процитировано

0
WuYou Decoction effectively reduces neuronal damage, synaptic dysfunction, and Aβ production in rats exposed to chronic sleep deprivation by modulating the Aβ-related enzymes and SIRT1/Nrf2/NF-κB pathway DOI
Zhenyu Wang, Dan Wu, Xinyi Hu

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 118939 - 118939

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Effects of one-night partial sleep deprivation on perivascular space volume fraction: Findings from the Stockholm Sleepy Brain Study DOI Creative Commons
Rachel M. Custer, Kirsten M. Lynch, Giuseppe Barisano

и другие.

Опубликована: Окт. 27, 2024

Abstract Increased waste clearance in the brain is thought to occur most readily during late-stage sleep (stage N3). Sleep deprivation disrupts time spent deeper stages, fragmenting process. Here, we have utilized publicly available Stockholm Sleepy Brain Study investigate whether various sleep-related measures are associated with changes perivascular space (PVS) volume fraction following a late-night short-sleep experiment. Our sample consisted of 60 participants divided into old (65-75 years) and young (20-30 age groups. We found that partial was not significantly major PVS changes. In centrum semiovale, observed an interaction between percentage total N3 status on fraction. basal ganglia, saw N2 (both absolute minutes) status. However, significance these findings did survive multiple comparisons corrections. This work highlights need for future longitudinal studies sleep, allowing quantification within-subject morphological occurring due patterns poor sleep. here provide insight impacts single night has system. Statement Significance issues been known be variety health risks. Recent research shown importance clearance, increases seen MRI represent both influx efflux pathways exchange cerebrospinal fluid (CSF) interstitial (ISF) parenchyma, key process underlying 1 Numerous recent links disruption no study date able examine resulting from experimental manipulation represents first looking at effects using automated segmentation technique.

Язык: Английский

Процитировано

0
Rewiring of the glymphatic landscape in metabolic disorders DOI
Bandy Chen, David Meseguer, Stéphanie Lenck

и другие.

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0