Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study DOI Creative Commons

H. Alexander Chen,

Ling Li,

Y P Sun

и другие.

Nature and Science of Sleep, Год журнала: 2025, Номер Volume 17, С. 97 - 113

Опубликована: Янв. 1, 2025

COVID-19 has led to reports of fatigue and sleep problems. Brain function changes underlying problems (SP) post-COVID-19 are unclear. This study investigated SP-related brain functional connectivity (FC) alterations. Fifty-five survivors with SP (COVID_SP) 33 without (COVID_NSP), matched for demographics, completed PSQI underwent rs-fMRI at baseline 2-month follow-up. Correlations between FC clinical data were analyzed by Pearson correlation analysis Gaussian random field (GRF) correction. The repeated-measures variance (R-M ANOVA) was explore the interaction time. At baseline, COVID_SP exhibited elevated FC: right precentral gyrus (PrG) left lateral occipital cortex (LOcC)/right PrG, inferior parietal lobule (IPL) superior frontal (SFG), hippocampus (IFG). Higher SFG correlated scores. follow-up, decreased implicated in emotion regulation, executive function, memory; increased semantics, attention, auditory-visual processing. these regions scores PSQI, GAD, PHQ. Repeated-Measures Analysis Variance revealed a significant time effect various scales. Moreover, PrG as well that IPL also discovered effect. provides insight into associated after COVID-19. These may partially explain development SP, they changed over

Язык: Английский

Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study DOI Creative Commons

H. Alexander Chen,

Ling Li,

Y P Sun

и другие.

Nature and Science of Sleep, Год журнала: 2025, Номер Volume 17, С. 97 - 113

Опубликована: Янв. 1, 2025

COVID-19 has led to reports of fatigue and sleep problems. Brain function changes underlying problems (SP) post-COVID-19 are unclear. This study investigated SP-related brain functional connectivity (FC) alterations. Fifty-five survivors with SP (COVID_SP) 33 without (COVID_NSP), matched for demographics, completed PSQI underwent rs-fMRI at baseline 2-month follow-up. Correlations between FC clinical data were analyzed by Pearson correlation analysis Gaussian random field (GRF) correction. The repeated-measures variance (R-M ANOVA) was explore the interaction time. At baseline, COVID_SP exhibited elevated FC: right precentral gyrus (PrG) left lateral occipital cortex (LOcC)/right PrG, inferior parietal lobule (IPL) superior frontal (SFG), hippocampus (IFG). Higher SFG correlated scores. follow-up, decreased implicated in emotion regulation, executive function, memory; increased semantics, attention, auditory-visual processing. these regions scores PSQI, GAD, PHQ. Repeated-Measures Analysis Variance revealed a significant time effect various scales. Moreover, PrG as well that IPL also discovered effect. provides insight into associated after COVID-19. These may partially explain development SP, they changed over

Язык: Английский

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