Altered Intra‐ and Inter‐Network Resting‐State Functional Connectivity is Associated with Neuropsychological Functioning and Clinical Symptoms in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder
Movement Disorders,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Abstract
Background
Isolated
rapid‐eye
movement
(REM)
sleep
behavior
disorder
(iRBD)
is
characterized
by
abnormal
behaviors
in
REM
and
considered
as
a
prodromal
symptom
of
alpha‐synucleinopathies.
Resting‐state
functional
magnetic
resonance
imaging
(rsfMRI)
studies
have
unveiled
altered
connectivity
(rsFC)
patients
with
iRBD.
However,
the
associations
between
intra‐
inter‐network
rsFC
clinical
symptoms
neuropsychological
functioning
iRBD
remain
unclear.
Objective
To
characterize
using
data‐driven
approach
to
assess
its
features
cognitive
functioning.
Methods
Forty‐two
45
healthy
controls
(HC)
underwent
rsfMRI
comprehensive
testing.
networks
were
independent
component
analyses.
Group
differences
their
data
studied.
A
threshold
corrected
P
<
0.05
was
used
all
Results
displayed
lower
intra‐network
within
basal
ganglia,
visual,
sensorimotor,
cerebellar
networks,
relative
HC.
Mean
strength
ganglia
network
positively
correlated
processing
speed
negatively
non‐motor
patients.
Reduced
sensorimotor
visual
medial
observed
patients,
which
associated
global
status.
Conclusions
both
reductions
cortical
subcortical
dysconnectivity
networks.
Abnormalities
are
performance
symptoms,
suggesting
utility
measures
markers
©
2025
The
Author(s).
Movement
Disorders
published
Wiley
Periodicals
LLC
on
behalf
International
Parkinson
Disorder
Society.
Язык: Английский
Motor events during REM sleep are associated with occipital lobe activity in Parkinson's Disease
Sleep Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Behavioral disorders in Parkinson disease: current view
Journal of Neural Transmission,
Год журнала:
2024,
Номер
132(2), С. 169 - 201
Опубликована: Окт. 25, 2024
Язык: Английский
Brain Network Analysis Reveals Hemispheric Aberrant Topology in Patients with idiopathic REM Sleep Behavior Disorder
Yi Sun,
Lifeng Qian,
Biwen Wu
и другие.
Brain Research Bulletin,
Год журнала:
2024,
Номер
unknown, С. 111176 - 111176
Опубликована: Дек. 1, 2024
Idiopathic
rapid
eye
movement
sleep
behavior
disorder
(iRBD)
is
recognized
as
a
prodromal
stage
of
neuro-degenerative
disease.
While
brain
network
analysis
well-documented
approach
for
characterizing
disease-related
dysfunctions,
the
specific
patterns
in
iRBD,
particularly
those
related
to
hemispheric
aberrations
remain
largely
unexplored.
To
address
this
gap,
study
investigated
topological
abnormalities
multi-band
EEG
networks
patients
with
iRBD.
Specifically,
eyes-open
resting-state
signals
were
collected
from
30
iRBD
and
matched
health
control
(HC)
participants.
Graph
theoretical
was
then
employed
explore
properties
at
whole-brain
level.
At
level,
we
found
aberrant
increased
local
global
efficiency
along
distinct
pattern
frontal
decreased
parietal
nodal
alpha
band
patients.
displayed
more
efficient
left
hemisphere.
Additionally,
significant
asymmetry
observed
alpha-band
compared
that
HC.
In
sum,
these
findings
provide
novel
insights
into
disrupted
reorganization
suggest
potential
neural
biomarker
early
diagnosis
monitoring
Язык: Английский