International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2923 - 2934
Опубликована: Март 1, 2025
Background:
Periodontitis,
one
of
the
most
common
oral
diseases
caused
by
bacterial
infection
which
affects
gums,
periodontal
ligament
and
alveolar
bone,
is
a
leading
cause
tooth
loss
in
adults.
Current
clinical
treatments,
such
as
scaling
or
antibiotics,
often
result
incomplete
biofilm
removal
can
contribute
to
drug
resistance.
Methods:
To
address
these
limitations,
nanozyme
comprising
platinum,
copper,
selenium
was
developed,
then
incorporated
into
thermoresponsive
hydrogel.
Results:
When
applied
pockets
exposed
808
nm
laser
irradiation,
hydrogel
became
soft,
dissolving
release
nanozyme.
This
demonstrated
superoxide
dismutase
(SOD)-like
catalase
(CAT)-like
activity,
reducing
excess
reactive
oxygen
species
(ROS)
while
displaying
strong
antibacterial
anti-inflammatory
effects.
Conclusion:
photothermal
showed
excellent
biocompatibility
has
potential
overcome
challenges
current
periodontitis
treatments.
Keywords:
thermosensitive,
therapy,
hydrogel,
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11802 - 11802
Опубликована: Ноя. 2, 2024
Antioxidants
have
a
well-established
effect
on
general
health
and
are
essential
in
preventing
oxidative
damage
to
cells
by
scavenging
free
radicals.
Free
radicals
thought
be
neutralized
these
substances,
which
include
polyphenols,
β-carotene,
vitamins
C
E,
reducing
cellular
damage.
On
the
other
hand,
recent
data
indicates
that
consuming
excessive
amounts
of
antioxidants
may
side
effects.
Apoptosis
cell
signaling
two
beneficial
physiological
processes
affected
supplementation.
Other
negative
effects
paradoxical
enhancement
stress
unbalanced
redox
potential.
Overdosing
particular
has
been
associated
with
increased
medication
interactions,
cancer
progression,
fatality
risks.
Additionally,
complex
impacts
they
fertility
might
both
useful
adverse,
depending
quantity
duration
usage.
This
review
delves
into
dual
role
emphasizes
importance
employing
moderation.
Antioxidant
overconsumption
disrupt
balance
necessary
for
normal
sperm
oocyte
function,
is
one
potential
males
females
also
investigated.
Although
modest
usage
generally
safe
useful,
high
levels
can
upset
hormonal
balance,
impair
motility,
negatively
impact
outcomes
assisted
reproductive
technologies
(ART).
The
findings
emphasize
need
use
antioxidant
supplements
balanced
way,
further
research
optimize
their
treatments,
supporting
avoid
adverse
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 18, 2025
Radiotherapy
(RT)
is
widely
applied
in
tumor
therapy,
but
inevitable
side
effects,
especially
for
skin
radiation
injury,
are
still
a
fatal
problem
and
life-threatening
challenge
patients.
The
main
components
of
topical
protection
preparations
currently
available
on
the
market
antioxidants,
such
as
SOD,
which
limited
by
their
unstable
activity
short
duration
action,
making
it
difficult
to
achieve
effects
damage
treatment.
Therefore,
we
designed
drug-free
antioxidant
hydrogel
patch
with
encapsulated
bioactive
epidermal
growth
factor
(EGF)
treatment
injury.
X-ray
responsive
formed
copolymerization
disulfide-containing
hyperbranched
poly(β-hydrazide
ester)
macromer
polymer
(PBAE),
methacryloylated
hyaluronic
acid,
acrylamide
exhibits
continuous
through
oxidation
disulfide
bonds
PBAE
well
triggered
release
EGF
after
breakage
network
finally
promote
radioactive
wound
healing.
Upon
radiotherapy,
able
alleviate
local
oxidative
stress
continuously
eliminating
excessive
ROS
can
prevent
deterioration
Moreover,
its
excellent
property
overcome
disadvantages
traditional
medicine
(such
poor
solubility,
random
diffusion,
rapid
drug
clearance,
interference
efficacy).
Notably,
negligible
effect
therapy
because
acts
only
epidermis
displays
no
shielding
ionization
radiation.
Ultimately,
vivo
animal
studies
affirm
efficacy
our
methodology,
wherein
administration
acute
irradiated
attenuates
progression
injury
promotes
This
innovative
strategy
points
out
new
inspiration
precise
hydrogels.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 19, 2025
Abstract
Dry
eye
disease
(DED)
is
a
multifaceted
ocular
surface
disorder
that
significantly
impacts
patients’
daily
lives
and
imposes
substantial
economic
burden
on
society.
Oxidative
stress,
induced
by
the
overproduction
of
reactive
oxygen
species
(ROS),
critical
factor
perpetuating
inflammatory
cycle
in
DED.
Effectively
scavenging
ROS
essential
to
impede
progression
In
this
study,
boronophenylalanine‐
containing
polydopamine
(PDA‐PBA)
nanoparticles
are
developed
loaded
with
melatonin
(MT),
which
blended
poly(vinyl
alcohol)
(PVA)
create
drops
PVA/
PDA‐PBA@MT
(PPP@MT).
vitro
vivo
studies
demonstrate
PPP@MT
exhibits
dual
functionalities
reducing
production
downregulating
pathways,
thereby
preserving
mitochondrial
integrity
further
inhibiting
programmed
cell
death.
Following
treatment,
tear
secretion,
corneal
structure,
number
goblet
cells
markedly
restored
mouse
model
dry
eye,
indicating
therapeutic
efficacy
agent.
Collectively,
PPP@MT,
characterized
minimal
side
effects
favorable
bioavailability,
offers
promising
insights
for
management
DED
other
ROS‐mediated
disorders.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2923 - 2934
Опубликована: Март 1, 2025
Background:
Periodontitis,
one
of
the
most
common
oral
diseases
caused
by
bacterial
infection
which
affects
gums,
periodontal
ligament
and
alveolar
bone,
is
a
leading
cause
tooth
loss
in
adults.
Current
clinical
treatments,
such
as
scaling
or
antibiotics,
often
result
incomplete
biofilm
removal
can
contribute
to
drug
resistance.
Methods:
To
address
these
limitations,
nanozyme
comprising
platinum,
copper,
selenium
was
developed,
then
incorporated
into
thermoresponsive
hydrogel.
Results:
When
applied
pockets
exposed
808
nm
laser
irradiation,
hydrogel
became
soft,
dissolving
release
nanozyme.
This
demonstrated
superoxide
dismutase
(SOD)-like
catalase
(CAT)-like
activity,
reducing
excess
reactive
oxygen
species
(ROS)
while
displaying
strong
antibacterial
anti-inflammatory
effects.
Conclusion:
photothermal
showed
excellent
biocompatibility
has
potential
overcome
challenges
current
periodontitis
treatments.
Keywords:
thermosensitive,
therapy,
hydrogel,
