Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1469 - 1469
Опубликована: Июль 3, 2024
The
immune
system
is
a
highly
complex
and
tightly
regulated
that
plays
crucial
role
in
protecting
the
body
against
external
threats,
such
as
pathogens,
internal
abnormalities,
like
cancer
cells.
It
undergoes
development
during
fetal
stages
continuously
learns
from
each
encounter
with
allowing
it
to
develop
immunological
memory
provide
wide
range
of
protection.
Over
time,
after
numerous
encounters
years
functioning,
can
begin
show
signs
erosion,
which
commonly
named
immunosenescence.
In
this
review,
we
aim
explore
how
responds
initial
antigens
handles
persistent
stimulations
throughout
person's
lifetime.
Our
understanding
has
greatly
benefited
advanced
technologies
flow
cytometry.
context,
will
discuss
valuable
contribution
cytometry
enhancing
our
knowledge
behavior
aging,
specific
focus
on
T-cells.
Moreover,
expand
discussion
cytometry-based
assessment
extracellular
vesicles,
recently
discovered
communication
channel
biology,
their
implications
for
functioning.
Journal of Translational Autoimmunity,
Год журнала:
2025,
Номер
10, С. 100269 - 100269
Опубликована: Янв. 8, 2025
Autoimmune
rheumatic
diseases
(ARDs)
are
a
heterogeneous
group
of
conditions
characterized
by
excessive
and
misdirected
immune
responses
against
the
body's
own
musculoskeletal
tissues.
Their
exact
aetiology
remains
unclear,
with
genetic,
demographic,
behavioural
environmental
factors
implicated
in
disease
onset.
One
prominent
hypothesis
for
initial
breach
tolerance
(leading
to
autoimmunity)
is
molecular
mimicry,
which
describes
structural
or
sequence
similarities
between
human
microbial
proteins
(mimotopes).
This
similarity
can
lead
cross-reactive
antibodies
T-cell
receptors,
resulting
an
response
autoantigens.
Both
commensal
microbes
microbiome
pathogens
trigger
thereby
potentially
contributing
onset
ARDs.
In
this
review,
we
focus
on
role
mimicry
rheumatoid
arthritis
systemic
lupus
erythematosus.
Moreover,
implications
also
briefly
discussed
ankylosing
spondylitis,
sclerosis
myositis.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 17, 2025
Human
longevity
is
a
sex-biased
process
in
which
sex
chromosomes
and
sex-specific
immunity
may
play
crucial
role
the
health
lifespan
disparities
between
men
women.
Generally,
women
have
higher
life
expectancy
than
men,
exhibiting
lower
infection
rates
for
broad
range
of
pathogens,
results
prevalence
female
centenarians
compared
to
males.
Investigation
immunological
changes
that
occur
during
healthy
aging,
while
taking
into
account
differences
sexes,
can
significantly
enhance
our
understanding
mechanisms
underlie
longevity.
In
this
review,
we
aim
summarize
current
knowledge
on
sexual
dimorphism
human
immune
system
gut
microbiome
with
particular
focus
centenarians,
based
exclusively
data.
Archives of Medical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Introduction
It
has
been
reported
that
individuals
with
type
1
diabetes
(T1D)
are
at
a
higher
risk
of
concomitant
occurrence
other
autoimmune
diseases
(AIDs).
Currently,
there
is
lack
research
investigating
the
causal
relationship
between
T1D
and
AIDs.
A
comprehensive
Mendelian
randomization
(MR)
study
was
conducted
using
debiased
inverse-variance
weighted
(dIVW)
(IVW)
estimators
to
examine
bidirectional
12
Material
methods
Genome-wide
association
(GWAS)
summary
statistics
datasets
related
or
AIDs
were
obtained
from
FinnGen
published
cohort
studies.
Pruned
SNPs
in
linkage
disequilibrium
(LD)-clumped
single-nucleotide
polymorphisms
(SNPs)
used
as
instrumental
variables.
For
dIVW
analysis,
no
genome-wide
significance
threshold
applied
for
SNP
selection.
Results
each
1-unit
increase
log-transformed
odds
ratio
(OR)
patients
primary
biliary
cholangitis
(PBC)
rheumatoid
arthritis
(RA),
ORs
1.123
(95%
CI:
1.094–1.151)
1.133
1.100–1.167),
respectively.
Conversely,
OR
T1D,
RA
1.383
1.213–-1.578).
No
associations
found
Conclusions
Patients
PBC
have
developing
those
also
an
increased
RA.
These
findings
highlight
importance
regular
screening
RA,
PBC.
Open Life Sciences,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Abstract
The
current
study
was
designed
to
explore
the
clinical
significance
of
serum
tissue
inhibitor
metalloproteinase
4
(TIMP4)
levels
in
rheumatoid
arthritis
(RA).
GSE1919
chip
analyzed,
differentially
expressed
genes
(DEGs)
were
identified,
and
gene
ontology
as
well
Kyoto
Encyclopedia
Genes
Genomes
analyses
identified
DEGs
conducted.
Patients
with
RA
(
n
=
96)
healthy
individuals
enrolled
this
study.
Serum
from
participants
collected,
RT-qPCR
WB
have
been
conducted
examine
TIMP4
levels;
additionally,
interleukin
(IL)-6
IL-1β
determined
using
ELISA
method.
Pearson’s
correlation
analysis
for
evaluating
relationships
between
expression
those
IL-6
or
IL-1β.
A
receiver
operating
characteristic
(ROC)
curve
drawn
determine
potential
diagnostic
value
RA.
a
markedly
downregulated
involved
development.
significantly
decreased
patients
RA,
results
ROC
showed
that
may
be
marker.
Furthermore,
concentrations
elevated
Finally,
negative
either
is
reliable
marker
diagnosis.
Abstract
As
global
life
expectancy
increases,
research
reveals
a
critical
challenge
in
aging:
the
progressive
deterioration
of
immune
function,
termed
immunosenescence.
This
age-related
decline
is
characterized
by
complex
dysregulation
responses,
which
leaves
older
adults
increasingly
vulnerable
to
infections,
chronic
inflammatory
states,
and
various
degenerative
diseases.
Without
intervention,
immunosenescence
significantly
contributes
morbidity
mortality
among
elderly,
intensifying
healthcare
burdens
diminishing
quality
on
both
individual
societal
levels.
review
explores
essential
role
zinc,
trace
element
for
health,
mitigating
impact
slowing
cascade
immunological
dysfunctions
associated
with
aging.
By
modulating
activity
key
cells
pathways,
zinc
supplementation
emerges
as
promising
approach
strengthen
immunity,
reduce
oxidative
stress,
counteract
"inflammaging,"
state
chronic,
low-grade
inflammation
that
accelerates
tissue
damage
drives
disease
progression.
Zinc’s
involvement
cellular
defense
repair
mechanisms
across
system
highlights
its
ability
enhance
cell
functionality,
resilience,
adaptability,
strengthening
body's
resistance
infection
manage
stressors
contribute
diseases
Indeed,
has
demonstrated
potential
improve
decrease
inflammation,
mitigate
risk
conditions
including
diabetes,
depression,
cardiovascular
disease,
vision
loss.
Given
prevalent
barriers
adequate
intake
adults,
dietary
limitations,
decreased
absorption,
interactions
medications,
this
underscores
urgent
need
address
deficiency
aging
populations.
Recent
findings
zinc’s
molecular
effects
health
present
practical,
accessible
intervention
supporting
healthier
improving
life.
integrating
into
targeted
strategies,
public
efforts
may
not
only
sustain
immunity
elderly
but
also
extend
healthy
longevity,
costs,
potentially
incidence
strain
systems
worldwide.
The Journal of Cardiovascular Aging,
Год журнала:
2025,
Номер
5(2)
Опубликована: Май 30, 2025
Aging
alters
the
immune
system,
leading
to
immunosenescence
characterized
by
impaired
T
cell
functions.
The
balance
between
regulatory
cells
and
type
17
helper
(Th17)
is
crucial
for
maintaining
peripheral
homeostasis.
disrupts
this
balance,
contributing
a
systemic
chronic
proinflammatory
environment
that
increases
prevalence
of
age-related
diseases.
Treg/Th17
imbalance
compromises
self-tolerance,
promoting
autoimmune
diseases
such
as
rheumatoid
arthritis,
lupus
erythematosus,
multiple
sclerosis.
Furthermore,
inflammation
driven
aberrant
responses
significant
risk
factor
progression
cardiovascular
(CVD),
including
hypertension,
atherosclerosis,
myocardial
infarction,
myocarditis.
Autoimmune
disorders
further
exacerbate
CVD,
which
remains
cause
mortality
among
patients
with
This
review
provides
an
in-depth
analysis
mechanisms
driving
during
aging,
highlighting
its
impact
on
homeostasis,
autoimmunity,
health.
It
explores
how
inflammaging
dysfunction
contribute
emphasizing
shared
pathways
therapeutic
strategies
restore
mitigate
inflammation.
Understanding
these
highlights
potential
restoring
tolerance
reduce
inflammation,
thereby
mitigating
onset
conditions.
