Insomnia in adult patients with cancer: ESMO Clinical Practice Guideline

ESMO Open, Год журнала: 2023, Номер 8(6), С. 102047 - 102047

Опубликована: Ноя. 21, 2023

•Insomnia is common in patients with cancer, a higher prevalence than observed the general population.•Insomnia often under-recognised and inadequately treated cancer.•Brief validated screening tools are available for evaluation of insomnia clinical practice.•First-line therapy should be based on international guidelines recommending cognitive behavioural insomnia.

Язык: Английский

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Allostatic Load and Endocrine Disorders

Psychotherapy and Psychosomatics, Год журнала: 2023, Номер 92(3), С. 162 - 169

Опубликована: Янв. 1, 2023

The building of life stress, well expressed by the concept allostatic load, plays an important part in all phases endocrine illness. Allostatic load refers to cumulative burden both stressful events and chronic stress. When environmental challenges exceed individual ability cope, overload ensues. Assessment load/overload clinical measurements including indices rating scales, addition biomarkers, offers a characterization person’s psychosocial environment that is missing from current formulations. Consideration endocrinology may shed light on number issues: interpretation abnormal hormone values lack explanations; coping with various illness; maladaptive illness behavior; response treatment; presence residual symptoms; health-damaging lifestyle habits. Addressing calls for innovative models outpatients multidisciplinary organization care, extended time interview, focus rehabilitation. We provide overview mechanisms how it can be assessed, its potential role disturbances, consideration lead needed innovation patient care.

Язык: Английский

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Time outdoors and residential greenness are associated with reduced systemic inflammation and allostatic load

Environmental Pollution, Год журнала: 2024, Номер 344, С. 123408 - 123408

Опубликована: Янв. 24, 2024

Язык: Английский

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Drivers of individual differences in the sleep behaviour of fallow deer neonates

Journal of Animal Ecology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Abstract Inter‐individual differences are necessary for selection to act, while plasticity (intra‐individual variation) may buffer against selection. Sleep is a critical self‐maintenance behaviour but, unlike most behaviours, the causes and consequences of its inter‐ intra‐individual variation in wild animals poorly understood, particularly neonates where sleep plays key role development. We have shown previously that free‐ranging neonate fallow deer ( Dama dama ) differ during first few weeks life. Here, we test whether individual variability organised systematically across population, these associated with chronic stress measured using hair cortisol, or timing birth. Four dimensions (total time, fragmentation, quality, distribution over 24‐h) were quantified state‐of‐the‐art triaxial accelerometers. then used multivariate mixed‐effects model Bayesian framework evaluate covariation between multiple behaviour, quantify relative importance birth, accounting confounding effects environmental conditions age. found birth not changes individuals. While both total time number bouts per day declined age, their rate development covaried, but no other covaried. Our results represent an in‐depth analysis natural sleep, show four aspects architecture free‐living fawns strong independent one another unrelated suggest might emerge later life cortisol be very short transient.

Язык: Английский

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Examining the Interaction between Exercise, Gut Microbiota, and Neurodegeneration: Future Research Directions

Biomedicines, Год журнала: 2023, Номер 11(8), С. 2267 - 2267

Опубликована: Авг. 14, 2023

Physical activity has been demonstrated to have a significant impact on gut microbial diversity and function. Emerging research revealed certain aspects of the complex interactions between gut, exercise, microbiota, neurodegenerative diseases, suggesting that changes in metabolic function may an onset progression neurological conditions. This study aimed review current literature from several databases until 1 June 2023 (PubMed/MEDLINE, Web Science, Google Scholar) interplay physical neurodegeneration. We summarized roles exercise microbiota neurodegeneration identified ways which these are all connected. The gut–brain axis is multifaceted network gained considerable attention recent years. Research indicates plays vital shifts during physiological or pathophysiological conditions diseases; therefore, they closely related maintaining overall health well-being. Similarly, shown positive effects brain cognitive function, reduce/delay severe disorders. Exercise associated with various neurochemical changes, including alterations cortisol levels, increased production endorphins, endocannabinoids like anandamide, as well higher levels serotonin dopamine. These linked mood improvements, enhanced sleep quality, better motor control, enhancements resulting exercise-induced effects. However, further clinical necessary evaluate bacteria taxa along age- sex-based differences.

Язык: Английский

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U‐shaped association between sleep duration and biological aging: Evidence from the UK Biobank study

Aging Cell, Год журнала: 2024, Номер 23(7)

Опубликована: Март 31, 2024

Previous research on sleep and aging largely has failed to illustrate the optimal dose-response curve of this relationship. We aimed analyze associations between duration measures predicted age. In total, 241,713 participants from UK Biobank were included. Habitual was collected baseline questionnaire. Four indicators, homeostatic dysregulation (HD), phenoAge (PA), Klemera-Doubal method (KDM), allostatic load (AL), chosen assess Multivariate linear regression models utilized. The association age followed a U-shape (All p for nonlinear <0.05). Compared with individuals who 7 h/day, multivariable-adjusted beta ≤5 ≥9 h/day 0.05 (95% CI 0.03, 0.07) 0.03 0.02, 0.05) HD, 0.08 0.01, 0.14) 0.36 0.31, 0.41) PA, 0.21 0.12, 0.30) 0.30 0.23, 0.37) KDM. Significant independent joint effects cystatin C (CysC) gamma glutamyltransferase (GGT) metrics future found. Similar results observed when conducting stratification analyses. Short long associated accelerated mediated by CysC GGT.

Язык: Английский

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Association of allostatic load measured by allostatic load index on physical performance and psychological responses during arduous military training

Physiological Reports, Год журнала: 2025, Номер 13(6)

Опубликована: Март 1, 2025

Abstract Military personnel experience decrements in physical fitness and psychological well‐being during training that may be attributed to allostatic load. This investigation examined the association between load measured by index (ALI) performance responses undergoing a 10‐week course. Thirty‐one participants (14 women) provided biochemical, questionnaire (perceived stress appraisal (PSS), sleep difficulty (SD), resilience (CD‐RISC‐25), Physical Fitness Test (PFT; three‐mile run [3MR], pullups, Run‐Row PFT score, Push‐Pull Crunches‐Plank total score)) data before after training. ALI (0–8) was calculated using biomarker components from neuroendocrine, autonomic, immune systems. Simple linear regression analysis assessed change (Δ) responses. Backward stepwise identified associated with ( α = 0.05). In men, ΔALI Δpullups β −0.88, p 0.015), Δpush‐pull score −2.87, 0.013), Δtotal −3.48, 0.007), ΔSD −0.56, 0.046) explaining relationships. women, −1.25, < 0.001) ΔCD‐RISC‐25 2.65, 0.025) no component Increased is worsened men improved outcomes highlighting potential sex‐specific increased

Язык: Английский

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Does Relative Energy Deficiency in Sport (REDs) Syndrome Exist?

Sports Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский

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Allostatic Load Is Associated with Overuse Musculoskeletal Injury during US Marine Corps Officer Candidates School

Medicine & Science in Sports & Exercise, Год журнала: 2024, Номер 56(11), С. 2220 - 2229

Опубликована: Июнь 27, 2024

ABSTRACT Introduction Overuse musculoskeletal injuries (MSKI) remain a significant medical challenge in military personnel undergoing training courses; further understanding of the biological process leading to overuse MSKI development and signatures for injury risk are warranted. The purpose this study was determine association between occurrence physiological characteristics allostatic load characterized as maladaptive responses chronic stress measured by wearable devices US Marine Corps officer candidates during 10-wk course. Methods Devices recorded energy expenditure (EE), daytime heart rate (HR), sleeping HR, sleep architecture (time percentage deep, light, rapid eye movement sleep, awake time, total sleep). Flux calculated raw or absolute difference average value that day night beforehand. Linear mixed-effect model analysis accounting cardiorespiratory fitness assessed device metrics ( α = 0.05). Results Sixty-nine participants (23 females) were included. Twenty-one (eight sustained MSKI. male positively associated with HR β 5.316, P 0.008), 2.708, 0.032), relative EE 8.968, 0.001), flux 2.994, 0.002), 626.830, 204.062, 0.004). female 5.955, 0.026), deep time 0.664, < percent 12.564, 0.001) negatively −0.660, 0.009). Conclusions occurrences load, including chronically elevated greater restorative stages, which may serve risk.

Язык: Английский

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Sleep Health, Self-Medication, and Cannabis Risk: A Bidirectional Model and Research Agenda

Current Sleep Medicine Reports, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 3, 2025

Язык: Английский

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