Abstract
N
‐heterocyclic
carbenes
(NHCs)
are
a
class
of
compounds
known
for
their
biological
activities
which
the
presence
therapeutic
metal
can
enhance.
The
discovery
cisplatin
as
an
effective
anticancer
metallodrug
led
to
research
into
other
metal‐based
drugs,
not
only
but
applications
such
antimicrobial,
antirheumatic,
and
antidiabetic.
Since
metallic
silver
has
been
have
antimicrobial
efficacy,
Ag(I)‐NHC
complexes
developed
enhance
efficacy
both
NHC.
In
this
study,
we
present
current
review
activity
several
azolium
salts
corresponding
NHC
coinage
metals
(Ag,
Au,
Cu
in
order
importance).
We
fully
analyzed
discussed
efficacies
when
benchmarked
against
commercially
available
drugs.
Also
highlighted
where
studies
based
on
structure‐activity
relationships,
included
variations
wingtip
‐substituents
ligands
changes
type,
number
oxidation
state
ions
complex.
British Journal of Sports Medicine,
Год журнала:
2023,
Номер
57(17), С. 1098 - 1110
Опубликована: Сен. 1, 2023
The
2023
International
Olympic
Committee
(IOC)
consensus
statement
on
Relative
Energy
Deficiency
in
Sport
(REDs)
notes
that
exposure
to
low
energy
availability
(LEA)
exists
a
continuum
between
adaptable
and
problematic
LEA,
with
range
of
potential
effects
both
health
performance.
However,
there
is
variability
the
outcomes
LEA
among
individuals
as
well
specific
manifestations
REDs.
We
outline
framework
for
‘systems
biology’
examination
effect
individual
body
systems,
eventual
goal
creating
an
integrated
map
system
interactions.
provide
template
systematically
identifies
characteristics
(eg,
magnitude,
duration,
origin)
variety
moderating
factors
medical
history,
diet
training
characteristics)
could
exacerbate
or
attenuate
type
severity
impairments
performance
faced
by
athlete.
REDs
Physiological
Model
may
assist
diagnosis
underlying
causes
problems
associated
personalised
nuanced
treatment
plan
promoting
compliance
efficacy.
It
also
be
used
strategic
prevention
drawing
attention
scenarios
which
are
most
likely,
based
knowledge
increase
risk
harmful
outcomes.
challenge
researchers
practitioners
create
unifying
dynamic
physiological
model
each
can
continuously
updated
mapped
gained.
International Journal of Psychophysiology,
Год журнала:
2025,
Номер
209, С. 112524 - 112524
Опубликована: Фев. 4, 2025
The
use
of
psychotropic
substances
has
negative
short-
and
long-term
health
outcomes,
including
complex
direct
indirect
effects
on
sleep
sleep-cardiovascular
function.
Here,
we
investigate
daily
relationships
between
self-reported
substance
objective
measures
sleep-related
heart
rate
(HR)
in
community-dwelling
young
adults.
Fifty-five
healthy
adults
(Mage
=
23.1
±
2.29
y,
30
female)
the
National
Consortium
Alcohol
Neurodevelopment
Adolescence
(NCANDA)
study
completed
a
28-day
ecological
momentary
assessment
protocol,
remote
HR
measurements
via
Fitbit
devices,
as
well
app-based
self-reports
alcohol
other
use.
A
total
1459
days
data
were
collected.
Caffeine
was
most
frequent
used,
followed
by
alcohol,
cannabis,
nicotine,
drugs.
analysis
showed
that
associated
with
delays
start
end
time,
reduced
duration
efficiency,
increased
wake
after
onset.
Increases
prior-day
Substance
negatively
influences
HR.
These
preliminary
highlight
potential
value
using
multimodal
collection
to
adults,
an
setting.
Brain and Behavior,
Год журнала:
2025,
Номер
15(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Background
Sleep
disturbances
have
become
increasingly
prevalent
in
modern
society.
Research
suggests
that
a
deficiency
magnesium
(Mg)
may
contribute
to
sleep
disturbances.
This
study
aims
investigate
the
association
between
daily
Mg
intake
and
self‐reported
duration
disorders
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods
The
dataset
includes
participants
five
cycles
(2009–2018)
of
NHANES.
associations
are
analyzed
weighted
logistic
regression.
Results
Baseline
characteristics
21,840
were
analyzed.
was
independently
associated
with
(OR
=
1.07,
95%
CI
(1.01–1.14),
p
0.024).
Higher
quartiles
food
normal
duration.
However,
did
not
differ
those
without
0.96,
(0.90–1.03),
0.238).
Among
3923
supplementation
data,
no
significant
differences
found
top
bottom
50%
supplementary
groups
regarding
or
disorders.
Conclusions
Dietary
is
short
but
either
Phytotherapy Research,
Год журнала:
2023,
Номер
37(12), С. 5558 - 5598
Опубликована: Сен. 7, 2023
Abstract
Caffeine,
which
shares
consubstantial
structural
similarity
with
purine
adenosine,
has
been
demonstrated
as
a
nonselective
adenosine
receptor
antagonist
for
eliciting
most
of
the
biological
functions
at
physiologically
relevant
dosages.
Accumulating
evidence
supports
caffeine's
beneficial
effects
against
different
disorders,
such
total
cardiovascular
diseases
and
type
2
diabetes.
Conversely,
paradoxical
are
also
linked
to
caffeine
ingestion
in
humans
including
hypertension–hypotension
tachycardia–bradycardia.
These
observations
suggest
association
action
its
ingested
concentration
and/or
concurrent
interaction
preferential
molecular
targets
direct
explicit
events
human
body.
Thus,
coherent
analysis
functional
caffeine,
normal
physiology,
disease
pathophysiology,
is
required
understand
pharmacology
caffeine.
This
review
provides
broad
overview
experimentally
validated
particularly
those
therapeutic
interest,
impacts
on
organ‐specific
physiology
pathophysiology.
Overall,
available
empirical
epidemiological
dose‐dependent
activities
advocates
further
studies
get
insights
into
caffeine‐induced
changes
under
specific
conditions,
asthma,
DNA
repair,
cancer,
view
applications.
Nutrients,
Год журнала:
2023,
Номер
16(1), С. 131 - 131
Опубликована: Дек. 30, 2023
Poor
sleep
health
is
common
in
older
adults
and
associated
with
negative
outcomes.
However,
the
relationship
between
caffeine
consumption
at
an
age
poorly
understood.
This
study
investigated
association
community-dwelling
males
females
The
Netherlands.
Cross-sectional
analyses
were
performed
using
data
from
1256
participants
aged
61-101
years
Longitudinal
Ageing
Study
Amsterdam.
Self-reported
questions
assessed
disturbances
(including
latency,
continuity,
early
awakening),
duration,
perceived
quality.
Caffeine
was
determined
about
frequency,
quantity,
type
of
coffee
tea
consumption.
Logistic
linear
regression
models
used,
controlling
for
potential
confounders,
interaction
by
sex
tested.
showed
significant
interactions
(p
<
0.005)
Older
who
abstained
reported
more
(β
=
0.64
[95%CI
0.13;
1.15])
had
greater
odds
short
duration
(<7
h/day)
(OR
2.26
[95%
CI
1.22;
4.20])
compared
to
those
consumed
caffeine.
No
associations
observed
long
(>8
males.
abstinence
females,
but
not
may
reflect
reverse
causation,
suggesting
that
have
different
motivations
discontinuing
than
