Talanta, Год журнала: 2024, Номер 274, С. 126074 - 126074
Опубликована: Апрель 8, 2024
Язык: Английский
Analytical Chemistry, Год журнала: 2024, Номер 96(10), С. 4224 - 4231
Опубликована: Фев. 29, 2024
The detection of physiological phosphates (PPs) is great importance due to their essential roles in numerous biological processes, but the efficient different PPs simultaneously remains challenging. In this work, we propose a fluorescence sensor array for detecting based on metal-ion-regulated gold nanoclusters (AuNCs) via an indicator-displacement assay. Zn2+ and Eu3+ are selected assemble with two AuNCs, resulting quenching or enhancing fluorescence. Based competitive interaction metal ions AuNCs PPs, will be recovered owing disassembly AuNC-metal ion ensembles. Depending PPs' distinct responses, four-channel was established. not only exhibits good discrimination capability eight kinds (i.e., ATP, ADP, AMP, GTP, CTP, UTP, PPi, Pi) linear discriminant analysis also enables quantitative single phosphate (e.g., ATP) presence interfering mixtures. Moreover, potential application present real samples cell lysates serum) successfully demonstrated performance. This work illustrates ion-regulated as new sensing platform differential well other disease-related biomolecules.
Язык: Английский
Процитировано
19
Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(1)
Опубликована: Янв. 1, 2024
Abstract Food contaminants present a significant threat to public health. In response escalating global concerns regarding food safety, there is growing demand for straightforward, rapid, and sensitive detection technologies. Noble metal nanoclusters (NMNCs) have garnered considerable attention due their superior attributes compared other optical materials. These include high catalytic activity, excellent biocompatibility, outstanding photoluminescence properties. features render NMNCs promising candidates crafting nanosensors contaminant detection, offering the potential development of uncomplicated, swift, sensitive, user‐friendly, cost‐effective approaches. This review investigates based on NMNCs, including synthesis methodologies sensing strategies, applications in detecting contaminants. Furthermore, it involves comparative assessment performance. Ultimately, this paper imparts fresh perspectives forthcoming challenges. Hitherto, (particularly fluorescent) founded demonstrated exceptional capabilities realm detection. To enhance performance, future research should prioritize atomically precise synthesis, augmentation activity properties, high‐throughput multimode sensing, integration with microfluidic devices, optimization storage, shelf life, transportation conditions.
Язык: Английский
Процитировано
17
ACS Applied Nano Materials, Год журнала: 2023, Номер 6(14), С. 12609 - 12672
Опубликована: Июль 19, 2023
Nanoclusters are nanostructures consisting of few to tens atoms which have attracted great interest from the scientific community due their applications in a myriad fields, catalysis biomedical applications. Due discrete energy levels resulting ultrasmall size, nanoclusters exhibit distinctly different chemical, optical, and electrical properties compared with larger nanoparticle counterparts. Unlike previously reported dimensions (1–10 nm), typically single advantage (for example, high conductivity or optical properties), can be used as signaling and/or reaction-accelerating materials almost all sensing assays enhanced properties. among most promising luminescent emitters (electrochemiluminescent, fluorescent, chemiluminescent, colorimetry) quantum yield better biocompatibility than conventional emitters. Considering excelent biocompatibility, tailored modification, desirable electrochemical tunability, opened new horizons designing high-performance biosensing devices. In addition, they represent excellent photoelectrochemical behaviors improved functionality environmentally friendly traditional compounds. This review discusses recent advances nanoclusters, biosensing, current limitations, prospects overcome these challenges. The present study gives much brighter vision that one by particular advantages role developing frameworks.
Язык: Английский
Процитировано
23
Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(27), С. 5871 - 5891
Опубликована: Март 4, 2024
Язык: Английский
Процитировано
10
Small, Год журнала: 2024, Номер 20(45)
Опубликована: Июль 16, 2024
The tracking of nanomedicines in their concentration and location inside living systems has a pivotal effect on the understanding biological processes, early-stage diagnosis, therapeutic monitoring diseases. Nanoscale metal-organic frameworks (nano MOFs) possess high surface areas, definite structure, regulated optical properties, rich functionalized sites, good biocompatibility that allow them to excel wide range biomedical applications. Controllable syntheses functionalization endow nano MOFs with better properties as imaging agents sensing units for diagnosis treatment This minireview summarizes tunable synthesis strategies controllable size, shape, luminescent performance, pinpoints recent advanced applications elements bioimaging biosensing. current limitations future development directions MOF-contained materials biosensing are also discussed, aiming expand MOF-based nanomedicine facilitate production or clinical translation.
Язык: Английский
Процитировано
10
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Aggregation-induced emission (AIE) or aggregation-induced enhancement (AIEE) has endowed gold species with responsive fluorescent properties, favoring their potential applications in sensing, imaging, and therapy. However, it remains an interesting challenge to fabricate fluorophores both AIE AIEE effects. Herein, we presented highly luminescent Au(I) thiolate nanocomplex-based biosensors Zn2+ induced-AIE zeolite imidazolate framework (ZIF-8) induced-AIEE The nonemissive monovalent gold–glutathione complexes (AuI-SGs) were obtained synthesize the core–shell Zn2+/AuI-SG@ZIF-8 composites strong luminescence via coordination-assisted self-assembly strategy. By immobilizing GOx on surface of Zn2+/AuI-SG@ZIF-8, Zn2+/AuI-SG@ZIF-8/GOx exhibited effective responsiveness glucose, showing a "turn-off" detection model. mechanism study revealed that robust glucose sensing was attributed acid-stimulated degradation probe facilitated by H+ generated from oxidase (GOx)-catalyzed oxidation process. To achieve noninvasive intelligent blood detection, Zn2+/AuI-SG@ZIF-8/GOx-loaded microneedle (MN)-patch platform further developed. MN-patch-based had promising performance for on-needle capture situ detection. This demonstrated universal feasible protocol construct development MN-based analytical devices.
Язык: Английский
Процитировано
1
Materials Horizons, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Significant advancements have been made in biochemical sensing, particularly the design, development, and utilization of metallic nanoclusters metal–organic frameworks as separate functional materials.
Язык: Английский
Процитировано
1
TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 170, С. 117443 - 117443
Опубликована: Ноя. 18, 2023
Язык: Английский
Процитировано
17
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 180, С. 117919 - 117919
Опубликована: Авг. 17, 2024
Язык: Английский
Процитировано
8
Sensors and Actuators B Chemical, Год журнала: 2024, Номер 417, С. 136069 - 136069
Опубликована: Июнь 4, 2024
Язык: Английский
Процитировано
7