ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

The special pathological microenvironment of infected wounds (pathology weakly acidic, hypoxic, and overexpressed H2O2) provides fertile soil for the development disease. Tailoring treatment based on specific characteristics infectious (IME) has emerged as a novel direction in antimicrobial therapies. Here, polyoxovanadate (POV)-based covalent organic polymer (POV-Fc-COP) with inherent photothermal activity was facilely prepared via copolymerization 1,1′-bi(3-dimethylamino-1-oxo-2-enyl-ferrocene) (BDOEF) tris-NH2-modified POV (tris-V6O9), which nanovanadium oxide (V2O3 V2O5) core shell were generated directly during Michael addition–elimination reaction. unique structure composition impart pH-responsive peroxidase-like (POD-like) catalase-like (CAT-like) activities, concurrently, to POV-Fc-COP. Specifically, acid-activated mimicking-POD could consume H2O2 microenvironment, producing toxic •OH combat bacteria biofilms. vanadium consumes excessive acid, resulting an increase pH. Meanwhile, CAT-like transform excess expression into O2 relieve hypoxia induced by damage blood vessels facilitate wound healing. Additionally, synergistic amplified therapeutic effect triggered application laser irradiation facilitates rapid eradication biofilm, minimizing detrimental impacts bacterial proliferation IME, thereby accelerating restoration IME return normal state. Therefore, POV-Fc-COP dual-enzyme functionality not only utilize but also regulate significantly expediting healing bacteria-infected wounds. This study demonstrates simple method preparation intelligent platform programmed antibacterial antibiofilm formation, thus promoting while utilizing improving IME.

Язык: Английский