Stimuli-induced adjustment of spatial distribution of fluorescence resonance energy transfer dyads in smart polymers

Coordination Chemistry Reviews, Год журнала: 2023, Номер 500, С. 215518 - 215518

Опубликована: Ноя. 2, 2023

Язык: Английский

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Molecule Engineering Metal–Organic Framework-Based Organic Photoelectrochemical Transistor Sensor for Ultrasensitive Bilirubin Detection

Analytical Chemistry, Год журнала: 2024, Номер 96(31), С. 12739 - 12747

Опубликована: Июль 26, 2024

The functionalization of metal-organic frameworks (MOFs) with organic small molecules by in situ postsynthetic modification has garnered considerable attention. However, the precise engineering recognition sites using this method remains rarely explored optically controlled bioelectronics. Herein, employing Schiff base reaction to embed molecule (THBA) into a Zr-MOF, we fabricated hydroxyl-rich MOF on surface titanium dioxide nanorod arrays (U6H@TiO

Язык: Английский

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Diselenides as novel effective fluorescence quenchers to construct a two-photon fluorescent probe for thiols in a mouse stroke model

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A fluorescence quenching mechanism using linear diselenides was proposed for the first time through a combination of intramolecular charge transfer (ICT) and Förster resonance energy (FRET).

Язык: Английский

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1,8-naphthalimide-triphenylamine-based red-emitting fluorescence probes for the detection of hydrazine in real water samples and applications in bioimaging in vivo

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 398, С. 134725 - 134725

Опубликована: Окт. 5, 2023

Язык: Английский

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Rational design of a ratiometric fluorescent nanoprobe for real-time imaging of hydroxyl radical and its therapeutic evaluation of diabetes

Biosensors and Bioelectronics, Год журнала: 2023, Номер 246, С. 115868 - 115868

Опубликована: Ноя. 26, 2023

Язык: Английский

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Accurate detection depression cell model with a dual-locked fluorescence probe in response to noradrenaline and HClO

Bioorganic Chemistry, Год журнала: 2024, Номер 146, С. 107296 - 107296

Опубликована: Март 22, 2024

Язык: Английский

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User-Friendly Multifunctional Red-Emissive Carbon Dots for Rapid Cell Nucleus Staining via Targeting Nuclear Proteins

Analytical Chemistry, Год журнала: 2024, Номер 96(21), С. 8432 - 8440

Опубликована: Май 6, 2024

Cytoarchitectural staining is of great importance in disease diagnosis and cell biology research. This study developed user-friendly multifunctional red-emissive carbon dots (R-CDs) for rapid nucleus via targeting nuclear proteins. R-CDs, simply prepared by electrochemical treatment 1,2,4-benzenetriamine, exhibit strong emission at 635 nm when excited 507 nm. The R-CDs can rapidly stain the human SH-SY5Y, HepG2, HUH-7 cells with a high signal-to-noise ratio owing to fluorescence enhancement after entering nucleus. Compared conventional cytosolic dyes such as Hoechst DAPI, are cheaper, more highly dispersed water, stable (requiring no stringent storage conditions). show optical properties insignificant photobleaching over 7 days salt resistance up 2 M NaCl. More importantly, possessing positive charge, allow live (3 min) dead (10 s) saline. According kinetic variation, distinguish from cells. Staining exhibits efficiency onion epidermal cells, Aspergillus niger, Caenorhabditis elegans, spermatozoa. mechanism efficient based on their fast accumulation due small size charge interaction proteins amino acid residues histidine arginine, resulting dozens times. do not bind DNA would cause genetic damage will find various safe applications biological medical fields.

Язык: Английский

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Hypochlorous Acid-Activatable NIR Fluorescence/Photoacoustic Dual-Modal Probe with High Signal-to-Background Ratios for Imaging of Liver Injury and Plasma Diagnosis of Sepsis

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Hypochlorous acid can be employed as a biomarker for blood infection (such sepsis) and tissue damage drug-induced liver injury, DILI), the diagnosis of or achieved through detection hypochlorous in relevant biological samples. Considering complex environment diverse interferences living organisms plasma, developing new methods HClO with high signal-to-background ratios is particularly important, it improve accuracy quality imaging based on higher contrast, which makes clearer more accurate. Here, advantages NIR fluorescence/photoacoustic dual-modal probe, we reported acid-activatable probe (NIRF-PA-HClO) spirolactam ring-opening strategy this paper. NIRF-PA-HClO showed excellent NIRF/PA responses SBRs solution, cells, mice. Moreover, was successfully applied high-contrast DILI. Finally, plasma sepsis satisfactory results. In summary, above results proved that would potentially useful tool study physiological pathological roles HClO, investigation pathology therapeutic mechanisms hepatotoxicity, infection. Also, development provides design mentality constructing other analyte-activatable probes SBRs.

Язык: Английский

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Detecting Changes in Singlet Oxygen and Viscosity during Apoptosis-Ferroptosis Mediated Photodynamic Therapy and Establishing Visual Imaging of Fatty Liver

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Cancer is a serious global health threat, and photodynamic therapy (PDT) an effective treatment method for cancer. This works by generating large amount of singlet oxygen (1O2) under the influence light, which induces apoptosis in tumor cells, leading to their destruction. However, resistance cells limits development PDT, thus combination ferroptosis provides new perspective PDT. During PDT ferroptosis, levels 1O2 microenvironment (viscosity) within often change. To address this, this study developed novel fluorescent probe, NI–QM-OH, based on TICT–ICT effect, capable monitoring changes viscosity during The probe exhibits excellent selectivity, high sensitivity, low LOD (0.38 μM), has been successfully applied bioimaging HepG2, HeLa, MCF-7 as well zebrafish. Most importantly, NI–QM–OH also enables visualization diagnosis fatty liver disease (both alcoholic nonalcoholic).

Язык: Английский

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Asymmetric D–A–D′ Ratiometric Molecule for Highly Specific Hypochlorous Acid Detection

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Hypochlorous acid exists as HClO in acidic conditions and ClO– alkaline conditions, posing a significant challenge for differentiation due to their strong closely similar oxidative reaction activities. Addressing this challenge, our study presents an asymmetric donor–acceptor–donor′ (D–A–D′) molecular architecture the design of fluorescent probe (PMT NPs) that demonstrates exceptionally high specificity toward alongside optimized ratiometric response. The incorporation electron acceptor 2-(diphenylmethylene)malononitrile (A) modulates reducing ability phenothiazine recognition site, adjusting probe's oxidation potential intermediate level between ClO–. This adjustment directly dictates selectivity, enabling it respond exclusively HClO. By incorporating D′, response shifts intramolecular charge transfer (ICT) from original D–A D′–A, instead usual Dox–A presented previous works. controls blue shift fluorescence wavelength upon recognition, thereby improving accuracy signals vivo. PMT NPs precisely recognize environments was validated through live cell imaging vivo experiments using zebrafish mouse models, real-time monitoring surges. dual-pronged strategy, which combines interaction modulation with D–A–D′ architecture, promises revolutionize designs various biomolecules is anticipated advance understanding diseases linked these analytes.

Язык: Английский

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