Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Biosensors, Год журнала: 2025, Номер 15(5), С. 320 - 320
Опубликована: Май 17, 2025
In this study, we present an innovative optical biosensor designed to detect Interleukin-6 (IL-6), a pivotal cytokine implicated in many pathological conditions. Our sensing platform is made of porous silicon (PSi) nanostructured substrate modified with thin (~5 nm) molecularly imprinted polymer (MIP), ensuring both high specificity and sensitivity toward IL-6 molecules. The fabrication process involves electrochemical etching chips create the structure, followed by electrodeposition MIP, which tailored selectively bind target. Extensive testing over broad concentration range demonstrates clear, proportional response, yielding limit detection (LOD) 13 nM. Moreover, robustness was verified evaluating its performance bovine serum, complex biological matrix. Despite presence various interfering components, sensor maintained selectivity displayed minimal matrix effects, underlining practical applicability real-world diagnostic scenarios.
Язык: Английский
Процитировано
0
Current Topics in Medicinal Chemistry, Год журнала: 2024, Номер 24(11), С. 986 - 1009
Опубликована: Апрель 1, 2024
This review explores the advancements in nanomaterial-based electrochemical sensors for multiplex detection of medicinal compounds. The growing demand efficient and selective methods pharmaceutical field has prompted significant research into development employing nanomaterials. These materials, defined as functional materials with at least one dimension between 1 100 nanometers, encompass metal nanoparticles, polymers, carbon-based nanocomposites, nano-bioprobes. are characterized by their enhanced sensitivity selectivity, playing a crucial role simultaneous offering comprehensive analysis multiple complexes within single sample. comprehensively examines design, fabrication, application nanomaterial- based sensors, focusing on ability to achieve various substances. Insights strategies nanomaterials employed enhancing sensor performance discussed. Additionally, challenges future perspectives this evolving field, highlighting potential impact advancement technologies.
Язык: Английский
Процитировано
2
ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(16), С. 9914 - 9921
Опубликована: Авг. 14, 2024
Molecularly imprinted polymers (MIPs) function as synthetic analogues of antibody–antigen systems that provide molecular recognition. In combination with an electrochemical interface, MIPs afford a promising route to selectively detect diverse range chemical analytes and environmental contaminants (e.g., per- polyfluoroalkyl substances, PFAS). However, mechanical instabilities binding irreversibility may limit the practical utility field-deployable sensor. Herein, we present directed optimization MIP-based sensors for PFAS by varying key fabrication parameters (i.e., potential window, scan rate, molar ratio) modulate properties sensing reversibility, measured atomic force microscopy (AFM)-based nanoindentation methods. We demonstrate elastic recovery MIP films strongly depends on synthesis rate during anodic polymerization. Furthermore, increase in significantly improves reversibility mitigates signal drift. anticipate understanding will insights into development robust reliable monitoring.
Язык: Английский
Процитировано
2
Biosensors and Bioelectronics, Год журнала: 2024, Номер 271, С. 117075 - 117075
Опубликована: Дек. 17, 2024
Язык: Английский
Процитировано
2
International Journal of Electrochemical Science, Год журнала: 2024, Номер 19(9), С. 100706 - 100706
Опубликована: Июнь 27, 2024
As an important proinflammatory cytokine, interleukin-6 (IL-6) possesses great influence in the treatment of several diseases (e.g. acute pancreatitis and infections) regulation immune, thus it's necessary to develop a simple sensitive method for IL-6 detection. In this work, by preparing defect‑engineered graphene nanoribbons (EGr) as substrate material sensor using 1,2-diaminobenzene functional monomer, molecularly imprinted polymer (MIP) voltammetric was successfully designed via electropolymerization detect IL-6. Because superior electrical property coupled with large surface area EGr high specific-recognition MIP, as-designed MIP exhibits wide linearity (0.1–1000 pg mL−1) low analytical limit (0.025 optimizing various influencing factors. addition, repeatability long-term stability well real application performances. The yielded acceptable performances based on developed reveal it could realize detection novel sensing platform.
Язык: Английский
Процитировано
1
Biosensors, Год журнала: 2024, Номер 14(9), С. 422 - 422
Опубликована: Авг. 30, 2024
Depression is currently a major contributor to unnatural deaths and the healthcare burden globally, patient's battle with depression often long one. Because causes, symptoms, effects of medications are complex highly individualized, early identification personalized treatment key improving outcomes. The development wearable electronics, machine learning, other technologies in recent years has provided more possibilities for realization this goal. Conducting regular monitoring through biosensing technology allows comprehensive objective analysis than previous self-evaluations. This includes identifying depressive episodes, distinguishing somatization analyzing etiology, evaluating effectiveness programs. review summarizes research on depression. Special attention given that can be portable or wearable, potential enable patient use outside hospital, periods.
Язык: Английский
Процитировано
1
Biosensors, Год журнала: 2024, Номер 14(10), С. 457 - 457
Опубликована: Сен. 25, 2024
Herein, we report a ratio-based electrochemical biosensor for the detection of interleukin-6 (IL-6). We electropolymerized methylene blue (MB) on surface screen-printed carbon electrodes; introduced an internal reference signal probe; modified carboxylate multi-walled nanotubes electrode to increase electrochemically active area; and finally linked amino-modified IL-6 aptamer through Schiff base reaction, with bovine serum albumin (BSA) added mask non-specific adsorption. After adding samples, I
Язык: Английский
Процитировано
1
Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(28), С. 6237 - 6257
Опубликована: Окт. 16, 2024
Abstract Interleukin-6 (IL-6) belongs to the cytokine family and plays a vital role in regulating immune response, bone maintenance, body temperature adjustment, cell growth. The overexpression of IL-6 can indicate various health complications, such as anastomotic leakage, cancer, chronic diseases. Therefore, availability highly sensitive specific biosensing platforms for detection is critical. In this study, first time, epitope-mediated IL-6-specific magnetic molecularly imprinted core–shell structures with fluorescent properties were synthesized using three-step protocol, namely, nanoparticle functionalization, polymerization, template removal following thorough optimization studies. polymers (MMIPs) characterized dynamic electrophoretic light scattering (DLS ELS), revealing hydrodynamic size 169.9 nm zeta potential +17.1 mV, while Fourier transform infrared (FTIR) spectroscopy fluorescence techniques showed characteristic peaks polymer tag, respectively. Scanning electron microscopy (SEM) high-resolution transmission (HRTEM) investigations confirmed successful encapsulation core within ca. 5-nm-thick polymeric shell. MMIP-based electrochemical sensing platform achieved limit 0.38 pM linear range 0.38–380 pM, indicating high affinity (dissociation constant K D = 1.6 pM) protein 50% diluted serum samples. Moreover, comparative non-imprinted control demonstrated an imprinting factor 4, confirming selectivity. With multifunctional features, including fluorescence, properties, target responsiveness, MMIPs hold significant application sensor well imaging.
Язык: Английский
Процитировано
1
The Analyst, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Molecularly imprinted polymer sensors, combined with electrochemical, optical, thermal, and acoustic detection technologies, detect biomarkers for key cardiovascular diseases: coronary artery disease, acute myocardial infarction, heart failure.
Язык: Английский
Процитировано
1
Macromolecular Bioscience, Год журнала: 2024, Номер unknown
Опубликована: Сен. 18, 2024
Addressing global challenges in wound management has greatly encouraged the emergence of home diagnosis and monitoring devices. This technological shift accelerated development new skin patch sensors for continuous health monitoring. A key requirement is creation flexible platforms capable mimicking human features. Here, first time, an innovative, highly adaptable electrochemical biosensor with molecularly imprinted polymers (MIPs) customized detection inflammatory biomarker interleukin-6 (IL-6). The 3-electrode gold pattern geometrically standardized onto a 6 µm thick polyimide membrane, optically transparent, biocompatible polymeric substrate. Subsequently, biomimetic sensing layer specifically designed IL-6 target produced on these transducers. obtained MIP shows good linear response within concentration range 50 pg mL
Язык: Английский
Процитировано
0