CRISPR-integrated metal-organic frameworks for biosensing applications: Recent advances and future perspective

Sensing and Bio-Sensing Research, Год журнала: 2025, Номер unknown, С. 100736 - 100736

Опубликована: Янв. 1, 2025

Язык: Английский

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Recent Advancements in Microfluidic Biosensors for Clinical Applications

iLABMED, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

ABSTRACT The combination of low‐consumption microfluidic chips and high‐sensitivity biosensors enables rapid accurate detection complex target analytes. This integrated system holds significant potential for applications in disease diagnosis, health monitoring, treatment management. Advances novel biomaterials have led to device integration into wearable implantable systems point‐of‐care testing. Here, we review recent advances clinical detecting nucleic acids, proteins, metabolites, pathogens, cellular components. We outline the prospects devices based on analysis biofluids such as sweat discuss remaining challenges facing application biosensors.

Язык: Английский

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Redefining nanobiosensors in rapid detection of viral infections: Where are we now?

Trends in Environmental Analytical Chemistry, Год журнала: 2025, Номер unknown, С. e00263 - e00263

Опубликована: Март 1, 2025

Язык: Английский

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Application of novel biosensors for detecting biomarkers of community-acquired pneumonia in children

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 114126 - 114126

Опубликована: Май 1, 2025

Язык: Английский

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A Bioinspired Microfluidic Nucleic Acid Sensing Platform for Rapid and Simultaneous Screening of Viral Respiratory Infections

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

In the postpandemic era, to tackle engineering challenge from concurrent outbreak of routine and emerging viral respiratory infections, microfluidic-chip-based point-of-care screening multiple pathogens becomes essential for decentralized epidemic diagnosis management. Toward real-world POCT, state-of-the-art microfluidic diagnostic devices are limited by in-plane design fluidic circuit, which highly relies on external pumping apparatus sample injection distribution thus greatly hampers their portability accessibility. this work, inspired pump-free water absorption mechanism plant root hairs, we report a self-powered hand-held sensing platform simultaneous rapid nucleic acid pathogens, such as influenza A B SARS-CoV-2. This lifts liquid port out principal plane circuit harness power gravity equal distribution. The root-hair-like channels enable fast directional transport biological specimen. Cascaded recombinase polymerase amplification lateral flow assay yield visual readout three in 40 min with competitive detection sensitivity low 0.18 copies/μL, close limit qPCR (gold standard). For real clinical specimens, retrospective research shows 93.2% specificity 97.7%. From an economic perspective, unit cost down 1.4 USD per test can generally be attained. leverages biomimetic structures boost cost-efficient POCT diagnostics, particularly infrastructure-deficient areas.

Язык: Английский

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An Fe₃O₄-Au heterodimer nanoparticle-based lateral flow assay for rapid and simultaneous detection of multiple influenza virus nucleic acids

Analytical Methods, Год журнала: 2024, Номер 16(34), С. 5777 - 5784

Опубликована: Янв. 1, 2024

An Fe 3 O 4 -Au nanoparticle-based LFA was developed for simultaneous detection of multiple influenza virus nucleic acids. This showed good accuracy and satisfactory sensitivity, could serve as a portable method early detection.

Язык: Английский

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Development of Immunochromatographic and Homogeneous Assay Based on Quantum Dot-Functionalized Polystyrene Nanoprobes for the Qualitative and Quantitative Screening of Respiratory Viruses

Biosensors and Bioelectronics, Год журнала: 2024, Номер 267, С. 116716 - 116716

Опубликована: Сен. 17, 2024

Язык: Английский

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