Aptasensor‐based point‐of‐care detection of cardiac troponin biomarkers for diagnosis of acute myocardial infarction

The Kaohsiung Journal of Medical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Abstract Acute myocardial infarction (AMI) represents a critical health challenge characterized by significant reduction in blood flow to the heart, leading high rates of mortality and morbidity. Cardiac troponins, specifically cardiac troponin I T, are essential proteins involved muscle contraction serve as vital biomarkers for diagnosis AMI. Aptasensors utilize synthetic aptamers or peptides with affinity specific offer promising approach integration into portable, user‐friendly point‐of‐care (POC) applications. This review explores recent advances POC aptasensor‐based platforms rapid detection biomarkers. Furthermore, this addresses current challenges potential future directions development aptasensor. Also, it highlights their improve timely accurate clinical emergency settings.

Язык: Английский

---

Quantitative immunoassay of prostate-specific antigen dependent on SERS substrate of polymer-silver nanocubes modified with 4-mercaptobenzoic acid: the crucial effect of thiol molecule as internal standard

Talanta, Год журнала: 2025, Номер 294, С. 128252 - 128252

Опубликована: Май 1, 2025

Язык: Английский

---

Reliable electrochemical ratiometric sensing based on diazotization/Schiff base reaction for accurate detection of alpha-fetoprotein

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161916 - 161916

Опубликована: Март 1, 2025

Язык: Английский

---

Au-Ag alloy nanourchins as a highly efficient SERS tag synergistically with MOF@Au for the ultrasensitive detection of oxytetracycline

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 695, С. 137840 - 137840

Опубликована: Май 8, 2025

Язык: Английский

---

Electrochemical ratiometric biosensor based on 2D flower-like Co/Ni MOF and sea urchin-like PdCuNi for accurate quantification of alpha-fetoprotein

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156248 - 156248

Опубликована: Сен. 1, 2024

Язык: Английский

---

A sensitive electrochemical biosensor based on Pd@PdPtCo mesoporous nanopolyhedras as signal amplifiers for assay of cardiac troponin I

Bioelectrochemistry, Год журнала: 2024, Номер 161, С. 108838 - 108838

Опубликована: Окт. 17, 2024

Язык: Английский

---

Sensitive ratiometric detection of Fumonisin B1 using a reusable ag-pSi SERS platform

Food Chemistry X, Год журнала: 2024, Номер 25, С. 102151 - 102151

Опубликована: Дек. 31, 2024

Язык: Английский

---

Enhanced electrochemical aptasensor integrating MoS2/CuS-Au and SI-RAFT for dual signal amplification in cTnI detection

Bioelectrochemistry, Год журнала: 2024, Номер 163, С. 108862 - 108862

Опубликована: Дек. 5, 2024

Язык: Английский

---

Ferricyanide-Mediated, Electrocatalytic Mechanism of Electrochemical Aptamer-Based Sensor Supports Ultrasensitive Analysis of Cardiac Troponin I in Clinical Samples

Langmuir, Год журнала: 2024, Номер unknown

Опубликована: Авг. 13, 2024

Rapid, reagent-free, and ultrasensitive analysis of cardiac troponin I (cTnI) is significance for early diagnosis acute myocardial infarction (AMI). The electrochemical aptamer-based (EAB) sensors are promising candidates to fill this role as they reagentless can be directly interrogated in complex matrices (e.g., blood). To achieve high sensitivity, EAB typically require nanomaterials or other amplification strategies, which often involves a cumbersome fabrication process. circumvent this, here we develop simple yet effective electrocatalytic (Ec-EAB) sensor that utilizes target-induced regulation the catalytic mechanism measurement cTnI. In assay, employed probe-attached redox reporter (i.e., methylene blue, MB) solution-diffusive Fe(CN)63–) generate two signals, latter used catalyze MB amplify aptamer-mediated charge transfer. recognition target altered diffusion catalysts (2.2 × 10–9 mol/cm2 target-free state versus 1.2 target-bound state) thus electrocatalytical efficiency, enabling cTnI with 1000-fold improvement their sensitivity (a limit detection value: 10 pg/mL).

Язык: Английский

---

An in situ ratiometric fluorescence immunosensor via Mn²⁺-triggered aggregation-induced emission transformation of levodopa fluorescent copolymer nanoparticles

Analytical Methods, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This communication demonstrates the feasibility of using Mn 2+ -triggered aggregation-induced emission transformation levodopa fluorescent copolymer nanoparticles as a direct in situ alkaline phosphatase-labeled luminescent nanoimmunoassay platform.

Язык: Английский

---