Smart fluorogenic tools: From designing principles to visualization of multistep protein aggregation DOI

Jingyang Wan,

Chen‐Yang Huang, Ziyue Chen

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216625 - 216625

Опубликована: Март 19, 2025

Язык: Английский

Plasmon-Enhanced Fluorescence Based on Gold Nanobipyramids with PEG-Controlled Distance for Near-Infrared and Visual Analysis of Amyloid-β Aggregation DOI
Wen Sun,

Jingtian Yu,

Xiaoyan Liang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

The number of cases Alzheimer's disease (AD) characterized by progressive amnestic syndrome is dramatically increased with population aging. It urgent to detect and diagnose this early. state amyloid-beta protein 1-42 (Aβ

Язык: Английский

Процитировано

0
Novel amyloid-β oligomer-targeted fluorescent probes DOI

Rikuto Kashiyama,

Hiroyuki Watanabe,

Takahiro Akasaka

и другие.

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112680 - 112680

Опубликована: Янв. 1, 2025

Процитировано

0
Nano-Collision Electrochemistry for Real-Time Monitoring of Amyloid-β Oligomerization and Rapid Screening of Degrading Drugs DOI
Jinrong Liu, Luan Chen, Zhiling Zhang

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Toxic oligomers of amyloid-β (Aβ) are important in the pathology Alzheimer's disease (AD), and degradation Aβ (AβO) brain is considered a promising strategy for drug development. However, conventional screening techniques face challenges rapid real-time assessment AβO. Here, we report simple reliable nanocollision electrochemical method based on silver nanoparticles (AgNPs) "tagging" that can situ monitor oligomerization screen potential AβO-degrading drugs. The differences collision signals between AgNPs-Aβ complexes AgNPs were compared to achieve identification with different aggregation degrees. effect following addition drugs be quickly evaluated by recovery frequency (f, number peaks per unit time), which effective if f > 0.15. Degradation efficiency was further quantified using current lifetimes (τ, time required decay 1/e original), percentage τ ≤ 10 ms. practicability tested Aβ-degrading protease several small molecules, confirming offering novel accelerate development AD treatment.

Язык: Английский

Процитировано

0
High brightness NIR luminescence BOPYINs: Synthesis, optical properties, acidic and viscosity response DOI
Yangyang Liu,

Furong Shi,

Ziyi Zhang

и другие.

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127344 - 127344

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Smart fluorogenic tools: From designing principles to visualization of multistep protein aggregation DOI

Jingyang Wan,

Chen‐Yang Huang, Ziyue Chen

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216625 - 216625

Опубликована: Март 19, 2025

Язык: Английский

Процитировано

0