
Chemosensors, Год журнала: 2024, Номер 12(8), С. 166 - 166
Опубликована: Авг. 17, 2024
Luminescent Ag nanoclusters (Ag NCs) are a promising probe material for sensing and bioimaging applications. However, the intrinsic obstacle of poor water stability photostability greatly restrict their practical application in biological systems. Herein, we report intracellular hypochlorite (ClO−) detection with amphiphilic copolymer-modified luminescent NCs good biocompatibility photostability. The were synthesized by using chemically inert hydrophobic ligands then modified an (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly(ethylene glycol))-2000]) (DSPE-PEG-2000) sodium dodecyl sulfonate (SDS) phase transfer. It was found that approach removal organic solvents during transfer has remarkable influences on properties NCs, including size, luminescence property, aqueous stability. Furthermore, silver core could be oxidatively damaged ClO−, thereby causing photoluminescence (PL) quenching. ClO−-induced PL quenching specific over other common reactive oxygen species (ROS) as well some interferences. Finally, they have been successfully applied fluorescent nanoprobe detecting exogenous endogenous ClO− living cells.
Язык: Английский