Microbiome-metabolome analysis insight into the effects of high-salt diet on hemorheological functions in SD rats

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Сен. 24, 2024

The present study examined the effect of two dietary regimens with elevated salt concentrations (4% and 8% salt) on hemorheological functions SD rats, explored underlying mechanisms mainly through microbiome-metabolome analysis. An HSD substantially altered parameters, compromised intestinal barrier integrity reduced short-chain fatty acid levels. analysis revealed that 49 genus-specific microorganisms 156 metabolites showed a consistent trend after exposure to both 4% HSDs. Pathway identified significant alterations in key within bile arachidonic metabolism pathways. A two-sample Mendelian randomization (MR) verified link between high intake hemorheology. It also suggested some microbes (such as

Язык: Английский

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Prevalence of Diabetes, Hypertension, and Associated of Cardiovascular Diseases: A Comparative Pre- and Post-Covid Study

Diseases, Год журнала: 2024, Номер 12(12), С. 329 - 329

Опубликована: Дек. 13, 2024

Background: Diabetes and hypertension are major global health challenges aggravated by COVID-19’s impact on healthcare lifestyle factors. This study aims to compare the prevalence associated socio-demographic factors of these conditions before after pandemic (2019 vs. 2022). Materials Methods: We used data from Italy’s “Aspects Daily Life” survey; 74,294 adults were included. Results: Results show a rise in diabetes 7.76% 2019 8.49% 2022 (p < 0.05), while did not this. Logistic regression analysis for years revealed statistically significant association between year increased odds (OR = 1.08, p 0.008). BMI’s role as risk factor intensified, with higher ratios (ORs) both overweight obese individuals 2022. For example, obesity-related ORs 2.45 (95%CI 1.73–3.47) 3.02 2.09–4.35) 2022, 2.86 2.28–3.58) 3.64 2.87–4.61). Lower education levels also showed greater 2022; subjects only middle or high school diplomas had significantly than education; there was non-significant trend 2019. However, lower remained stable years. Conclusions: These findings suggest that may have hypertension, particularly BMI educational level, compared literature burden chronic diseases during COVID-19.

Язык: Английский

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Cerebral cortex changes in FD, IBS, and GERD: A Mendelian randomization study

Journal of Affective Disorders, Год журнала: 2024, Номер 369, С. 1153 - 1160

Опубликована: Окт. 22, 2024

Язык: Английский

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Mediation Effect of Obesity on the Association of Socioeconomic Status with Blood Pressure in the Elderly Hypertensive Population

Nutrients, Год журнала: 2024, Номер 16(15), С. 2401 - 2401

Опубликована: Июль 24, 2024

Socioeconomic status (SES) plays a crucial role in blood pressure (BP) control. SES may influence BP control through obesity indices, such as body mass index (BMI) and waist circumference (WC). This study aimed to understand the relationships between elderly hypertensive population, determine whether BMI WC mediate relationship

Язык: Английский

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Deciphering the role of oxidative stress genes in idiopathic pulmonary fibrosis: a multi-omics mendelian randomization approach

Genes and Immunity, Год журнала: 2024, Номер 25(5), С. 389 - 396

Опубликована: Авг. 22, 2024

Язык: Английский

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Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization study

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Ноя. 25, 2024

Several blood proteins might be associated with the development of colorectal cancer (CRC), but many studies on this topic are often biased. By using genetic variation data, which is less influenced by environmental factors, we can better determine causal relationship between specific and occurrence cancer.

Язык: Английский

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Community-Based Occupational Health Promotion for Reducing Blood Pressure: A Randomized Control Trial of Agricultural Health Program

Journal of Occupational Health and Epidemiology, Год журнала: 2024, Номер 13(4), С. 252 - 260

Опубликована: Дек. 1, 2024

Язык: Английский

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