Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

Neuron, Год журнала: 2011, Номер 70(4), С. 687 - 702

Опубликована: Май 1, 2011

Язык: Английский

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The Glial Nature of Embryonic and Adult Neural Stem Cells

Annual Review of Neuroscience, Год журнала: 2009, Номер 32(1), С. 149 - 184

Опубликована: Июнь 1, 2009

Glial cells were long considered end products of neural differentiation, specialized supportive with an origin very different from that neurons. New studies have shown some glial cells—radial glia (RG) in development and specific subpopulations astrocytes adult mammals—function as primary progenitors or stem (NSCs). This is a fundamental departure classical views separating neuronal lineages early development. Direct visualization the behavior NSCs lineage-tracing reveal how emerge. In brain, many neurons are not direct progeny NSCs, but instead originate transit amplifying, intermediate, progenitor (IPCs). Within IPCs, genetic programs unfold for generating extraordinary diversity cell types central nervous system. The timing location property tightly linked to their neuroepithelial origin, appear be key determinants generated. Identification IPCs critical understand brain neurogenesis develop new strategies repair.

Язык: Английский

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Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

Cell stem cell, Год журнала: 2010, Номер 7(2), С. 150 - 161

Опубликована: Авг. 1, 2010

Язык: Английский

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Physiology of Astroglia

Physiological Reviews, Год журнала: 2017, Номер 98(1), С. 239 - 389

Опубликована: Дек. 24, 2017

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis and defense the central nervous system (CNS). highly heterogeneous in morphological appearance; they express a multitude receptors, channels, membrane transporters. This complement underlies their remarkable adaptive plasticity defines functional maintenance CNS development aging. tightly integrated into networks act within context tissue; astrocytes control at all levels organization from molecular to whole organ.

Язык: Английский

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Angiocrine functions of organ-specific endothelial cells

Nature, Год журнала: 2016, Номер 529(7586), С. 316 - 325

Опубликована: Янв. 1, 2016

Язык: Английский

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Corridors of migrating neurons in the human brain and their decline during infancy

Nature, Год журнала: 2011, Номер 478(7369), С. 382 - 386

Опубликована: Сен. 28, 2011

Язык: Английский

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Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells

Cell stem cell, Год журнала: 2011, Номер 8(5), С. 486 - 498

Опубликована: Май 1, 2011

Язык: Английский

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Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

Cell stem cell, Год журнала: 2015, Номер 17(3), С. 329 - 340

Опубликована: Июль 30, 2015

Язык: Английский

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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

Cell stem cell, Год журнала: 2015, Номер 17(4), С. 385 - 395

Опубликована: Окт. 1, 2015

Язык: Английский

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The brain tumor microenvironment

Glia, Год журнала: 2011, Номер 60(3), С. 502 - 514

Опубликована: Ноя. 22, 2011

Abstract High‐grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and a range intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some increased tumorigenicity stem cell‐like capacity. The stem‐like may be origin for relapse. However, tumor‐associated such as vascular cells, microglia, peripheral immune neural precursor also play vital role in controlling course pathology. In this review, we describe interactions bulk glioma populations highlight pathological impact well signaling pathways known these types cell‐cell communication. tumor‐vasculature not only nourishes glioblastomas, but provides specialized niche addition, microglial which can contribute up 30% mass, glioblastoma invasion. Moreover, non‐neoplastic astrocytes converted into reactive phenotype by microenvironment then secrete number factors influences biology. young have capacity inhibit gliomagenesis endogenous suppressive factors. factors, pathways, described review provide new prospective on biology primary tumors, ultimately generate treatment modalities. our picture between is still incomplete. © 2011 Wiley Periodicals, Inc.

Язык: Английский

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