Experimental Hematology, Год журнала: 2024, Номер 137, С. 104247 - 104247
Опубликована: Июнь 6, 2024
Язык: Английский
FEBS Letters, Год журнала: 2024, Номер unknown
Опубликована: Март 5, 2024
Aging is a set of complex processes that occur temporally and continuously. It generally unidirectional progression cellular molecular changes occurring during the life stages cells, tissues ultimately whole organism. In vertebrate organisms, this begins at conception from first steps in blastocyst formation, gastrulation, germ layer differentiation, organogenesis to continuum embryonic, fetal, adolescent, adult, geriatric stages. Tales “fountain youth” songs being “forever young” are dominant ideas informing us growing old something science should strive counteract. Here, we discuss normal blood system, particularly historical recognition its importance early growth vertebrates, what means with respect progressive gain loss hematopoietic function adult.
Язык: Английский
Процитировано
2
Current Opinion in Hematology, Год журнала: 2024, Номер 31(4), С. 207 - 216
Опубликована: Апрель 12, 2024
Purpose of review The development new antiaging medicines is great interest to the current elderly and aging population. Aging hematopoietic system attributed stem cells (HSCs), epigenetic alterations are key effectors driving HSC aging. Understanding epigenetics holds promise providing insights for combating age-related hematological malignancies. Recent findings characterized by progressive loss physiological integrity, leading impaired function increased vulnerability death. During aging, HSCs undergo both quantitative qualitative changes. These functional changes in cause dysregulated hematopoiesis, resulting anemia, immune dysfunction, an risk Various cell-intrinsic cell-extrinsic influencing have also been identified. Epigenetic one such mechanism. Summary Cumulative aged affect their fate, aberrant self-renewal, differentiation, HSCs. In turn, these factors provide opportunity expand modulating self-renewal differentiation balance, thereby contributing
Язык: Английский
Процитировано
2
Stem Cell Reviews and Reports, Год журнала: 2024, Номер 20(4), С. 1135 - 1149
Опубликована: Март 4, 2024
Abstract In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing secreted and membrane-bound paracrine signals. Within BM, distinct vascular arteriole, transitional, sinusoidal EC subtypes display unique expression profiles create anatomically-discrete microenvironments. However, relative contributions in supporting hematopoiesis is unclear. Moreover, constitutive off-target currently available endothelial-specific endothelial-subtype-specific murine cre lines potentially confound data analysis interpretation. To address this, we describe two tamoxifen-inducible -expressing lines, Vegfr3-creER T2 Cx40-creER , that efficiently label sinusoidal/transitional arteriole endothelium respectively marrow, without or perivascular cells. Utilizing established mouse model -dependent recombination constitutively-activates MAPK signaling within endothelium, identify ECs as driver MAPK-mediated dysfunction. These results define complementary creER functionally-discrete non-overlapping populations providing a robust toolset to investigate differential maintaining homeostasis. Graphical
Язык: Английский
Процитировано
1
Experimental Hematology, Год журнала: 2024, Номер 134, С. 104214 - 104214
Опубликована: Апрель 4, 2024
Programmed cell death is an evolutionally conserved cellular process in multicellular organisms that eliminates unnecessary or rogue cells during development, infection, and carcinogenesis. Hematopoietic stem (HSCs) are a rare, self-renewing, multipotent population necessary for the establishment regeneration of hematopoietic system. Counterintuitively, key components programmed induction abundantly expressed long-lived HSCs, which often survive myeloablative stress by engaging prosurvival response counteracts death-inducing stimuli. Although HSCs well known their apoptosis resistance, recent studies have revealed unique vulnerability to certain types necrosis, such as necroptosis ferroptosis. Moreover, emerging evidence has shown pathways can be sublethally activated cause nonlethal consequences innate immune response, organelle dysfunction, mutagenesis. In this review, we summarized findings on how divergent programs molecularly regulated HSCs. We then discussed potential side effects caused sublethal activation functionality surviving
Язык: Английский
Процитировано
1
Experimental Hematology, Год журнала: 2024, Номер 137, С. 104247 - 104247
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
1