Breast Cancer: Extracellular Matrix and Microbiome Interactions

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7226 - 7226

Опубликована: Июнь 30, 2024

Breast cancer represents the most prevalent form of and leading cause cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to appearance progression this disease. Despite advancements in breast treatment, a significant portion patients with distant metastases still experiences no cure. The extracellular matrix potential target for enhanced serum biomarkers cancer. Furthermore, degradation epithelial–mesenchymal transition constitute primary stages local invasion during tumorigenesis. Additionally, microbiome influence on diverse physiological processes. is emerging microbial dysbiosis element development various cancers, including Thus, better understanding interactions could provide novel alternatives treatment management. In review, we summarize current evidence regarding intricate relationship between microbiome. We discuss arising associations future perspectives field.

Язык: Английский

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Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression

Biomarker Research, Год журнала: 2025, Номер 13(1)

Опубликована: Янв. 23, 2025

The tumor microenvironment functions as a dynamic and intricate ecosystem, comprising diverse array of cellular non-cellular components that precisely orchestrate pivotal behaviors, including invasion, metastasis, drug resistance. While unraveling the interplay between behaviors represents tremendous challenge, recent research illuminates crucial biological phenomenon known mechanotransduction. Within microenvironment, mechanical cues like tensile stress, shear stiffness play role by activating mechanosensitive effectors such PIEZO proteins, integrins, Yes-associated protein. This activation initiates cascades intrinsic signaling pathways, effectively linking physical properties tissues to their physiological pathophysiological processes morphogenesis, regeneration, immunity. mechanistic insight offers novel perspective on how within impact behaviors. intricacies are yet be fully elucidated, it exhibits distinct attributes from non-malignant tissues, elevated solid stresses, interstitial hypertension, augmented matrix stiffness, enhanced viscoelasticity. These traits exert notable influences progression treatment responses, enriching our comprehension multifaceted nature microenvironment. Through this innovative review, we aim provide new lens decipher contexts, broadening knowledge these factors promote or inhibit thus offering valuable insights identify potential targets for anti-tumor strategies.

Язык: Английский

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Tension-induced organelle stress: an emerging target in fibrosis

Trends in Pharmacological Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Matrix stiffness induces heritable changes in chromosome numbers, consistent with solid tumor heterogeneity

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Abstract Solid tumors often have an abundance of collagen-I that stiffens the tissue, and they are invariably driven by mutations include chromosome losses gains. These observations linked here showing 3D matrix stiffness induces heritable changes to a cell ’ s DNA. We use live-cell reporters (ChReporters) hydrogels tunable show mitotic compression, micronuclei counts, ChReporter heterogeneity all increase as functions stiffness. Increased mistakes occur despite suppressed division in stiff minimal size variation between spheroids. Colonies ChReporter-negative cells within cancer spheroids align with Luria-Delbruck seminal theory for mutations, which predicts inter-spheroid variances exceed Poisson statistics. Suppression contractility motor Myosin-II also increases loss but not 2D does affect spheroid growth – thus clarifying putative role tumor suppressor. Consistent experiments, pan-cancer analyses clinical data associates gains levels genetic variation. Stiff extracellular drives mechano-evolution solid Darwin-Lamarck process complicates therapy.

Язык: Английский

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Collagen remodeling-mediated signaling pathways and their impact on tumor therapy

Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108330 - 108330

Опубликована: Фев. 1, 2025

Язык: Английский

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Exposomal determinants of non-genetic plasticity in tumor initiation

Trends in cancer, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis

The EMBO Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Abstract Fibroblasts form a major component of the stroma in normal mammary tissue and breast tumors. Here, we have applied longitudinal single-cell transcriptome profiling >45,000 fibroblasts mouse gland across five different developmental stages during oncogenesis. In gland, diverse stromal populations were resolved, including lobular-like fibroblasts, committed preadipocytes adipogenesis-regulatory, as well cycling puberty pregnancy. These specialized cell types appear to emerge from CD34 high mesenchymal progenitor cells, accompanied by elevated Hedgehog signaling. During late tumorigenesis, heterogeneous cancer-associated (CAFs) identified models cancer, population – myofibroblastic CAFs (myCAFs) that transcriptionally phenotypically similar senescent CAFs. Moreover, Wnt9a was demonstrated be regulator senescence myCAFs. findings reflect hierarchically organized compartment provides framework better understand cancerous states.

Язык: Английский

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Tissue mechanics in tumor heterogeneity and aggression

Trends in cancer, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Tumorigenesis ensues within a heterogeneous tissue microenvironment that promotes malignant transformation, metastasis and treatment resistance. A major feature of the tumor is population cancer-associated fibroblasts myeloid cells stiffen extracellular matrix. The heterogeneously stiffened matrix in turn activates cellular mechanotransduction creates hypoxic metabolically hostile microenvironment. elevated mechanosignaling also drive aggression by fostering cell growth, survival, invasion, compromising antitumor immunity, expanding cancer stem frequency, increasing mutational burden, which promote intratumor heterogeneity. Delineating molecular mechanisms whereby mechanics regulate these phenotypes should help to clarify basis for heterogeneity identify novel therapeutic targets could improve patient outcome. Here, we discuss role driving through its impact on

Язык: Английский

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Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering

Chem & Bio Engineering, Год журнала: 2024, Номер 1(11), С. 916 - 933

Опубликована: Окт. 8, 2024

The extracellular matrix (ECM) performs both as a static scaffold and dynamic, viscoelastic milieu that actively participates in cell signaling mechanical feedback loops. Recently, biomaterials with tunable properties have been utilized to mimic the native ECM fields of tissue engineering regenerative medicines. These materials can be designed support attachment, proliferation, differentiation, facilitating repair or replacement damaged tissues. Moreover, viscoelasticity modulation mimicry helps develop therapeutic strategies for diseases involving altered tissues such fibrosis cancer. study biomaterial thus intersects broad spectrum biological medical disciplines, offering insights into fundamental biology practical solutions improving human health. This review delves design fabrication hydrogels, focusing particularly on two major parameters, strength stress relaxation, how hydrogel mechanics influence interactions between living cells surrounding microenvironments. Meanwhile, this discusses current bottlenecks hydrogel-cell studies, highlighting challenges parameter decoupling, long-term stable maintenance microenvironment, general applicability testing standards conversion protocols.

Язык: Английский

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Interplay between hormonal and mechanical signals in mammary morphodynamics

Trends in Cell Biology, Год журнала: 2024, Номер 34(6), С. 434 - 436

Опубликована: Март 27, 2024

Язык: Английский

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