Cells,
Год журнала:
2024,
Номер
13(23), С. 1948 - 1948
Опубликована: Ноя. 23, 2024
Numerous
studies
have
demonstrated
the
significant
influence
of
immune
cells
on
cancer
development
and
treatment.
This
study
specifically
examines
tumor-associated
macrophages
(TAMs),
detailing
their
characteristics
roles
in
tumorigenesis
analyzing
impact
ratio
TAM
subtypes
patient
survival
prognosis.
It
is
established
that
TAMs
interact
with
immunotherapy,
radiotherapy,
chemotherapy,
thereby
influencing
efficacy
these
treatments.
Emerging
therapies
are
explored,
such
as
use
nanoparticles
(NPs)
for
drug
delivery
to
target
modify
tumor
microenvironment
(TME).
Additionally,
novel
anticancer
strategies
like
chimeric
antigen
receptor
(CAR-Ms)
show
promising
results.
Investigations
into
training
using
magnetic
fields,
plasma
stimulation,
electroporation
also
discussed.
Finally,
this
presents
prospects
combination
TAM-based
enhanced
treatment
outcomes.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 31, 2025
The
IL-2
family,
consisting
of
IL-2,
IL-4,
IL-7,
IL-9,
IL-15
and
IL-21,
is
a
key
regulator
the
immune
response.
As
an
important
endocrine
digestive
organ,
function
pancreas
regulated
by
system.
Studies
have
shown
that
each
cytokine
family
influences
occurrence
development
pancreatic
diseases
participating
in
regulation
In
this
paper,
we
review
structural
functional
characteristics
members,
focus
on
their
molecular
mechanisms
including
acute
pancreatitis,
chronic
pancreatitis
cancer,
highlight
importance
related
proteins
response
disease
progression,
which
will
provide
valuable
insights
for
new
biomarkers
diseases,
early
diagnosis
assessment
severity,
therapeutic
regimens.
study
are
summarized
following
sections.
Cancer-associated
myeloid
cells
due
to
their
plasticity
play
dual
roles
in
both
promoting
and
inhibiting
tumor
progression.
Myeloid
with
immunosuppressive
properties
a
critical
role
anti-cancer
immune
regulation.
Cells
of
different
origin,
such
as
associated
macrophages
(TAMs),
neutrophils
(TANs),
derived
suppressor
(also
called
MDSCs)
eosinophils
are
often
expanded
cancer
patients
significantly
influence
survival,
but
also
the
outcome
therapies.
For
this
reason,
variety
preclinical
clinical
studies
modulate
activity
these
have
been
conducted,
however
without
successful
date.
In
review,
pro-tumor
cells,
cell-specific
therapeutic
targets,
vivo
on
cell
re-polarization
impact
immunotherapies/genetic
engineering
addressed.
This
paper
summarizes
ongoing
trials
concept
chimeric
antigen
receptor
macrophage
(CAR-M)
therapies,
suggests
future
research
perspectives,
offering
new
opportunities
development
novel
treatment
strategies.
American Journal of Cancer Research,
Год журнала:
2025,
Номер
15(3), С. 1096 - 1108
Опубликована: Янв. 1, 2025
The
incidence
of
bladder
cancer
(BCa)
is
increasing
worldwide
and
the
development
drug
targets
for
BCa
necessary.
We
conducted
a
proteome-wide
association
study
(PWAS)
mainly
using
mendelian
randomization
(MR)
to
explore
causal
proteins
associated
with
BCa.
Protein
quantitative
trait
locis
(pQTLs)
were
derived
from
two
large
proteome
genome-wide
studies.
After
validation
by
multiple
sensitivity
analysis
replication
analyses,
we
identified
five
plasma
showed
significant
associations
Our
indicated
that
GSTM4
(OR
=
0.81
(0.74-0.89),
P
5.14
×
10-6,
PPH4
0.89)
emerged
as
most
reliable
target.
Besides,
PSCA,
LY6D,
SLURP1
GSTM1
also
clear
but
only
failed
in
colocalization.
performed
several
downstream
analyses.
Protein-protein
interactions
found
these
came
glutathione
S-transferase
family
or
lymphocyte
antigen-6
family.
Phenome-wide
MR
revealed
PSCA
may
lead
peptic
ulcer
local
infections
skin
subcutaneous
tissue.
then
employed
single-cell
analysis,
protein-protein
interactions,
druggability
evaluation.
was
assess
possible
side
effects
targets.
Finally,
reliability
confirmed
via
colony
formation
assay.
Biotechnology Progress,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Abstract
Induced
pluripotent
stem
cells
(iPSCs)
offer
significant
therapeutic
potential,
but
cryopreservation
challenges,
particularly
the
reliance
on
cytotoxic
Dimethyl
Sulfoxide
(Me
2
SO),
hinder
their
clinical
application.
This
review
examines
current
practices
in
and
preclinical
iPSC‐based
therapies,
highlighting
consistent
use
of
Me
SO
logistical
challenges
post‐thaw
processing.
The
findings
underscore
urgent
need
for
alternative
techniques
to
ensure
safety
efficacy
off‐the‐shelf
iPSC
therapies.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
SUMMARY
Tissue-resident
macrophages
(TRMs)
are
innate
immune
cells
that
participate
in
tissue
development,
homeostasis,
and
surveillance.
Extensive
efforts
have
been
made
to
recapitulate
TRM
development
from
pluripotent
stem
(PSCs)
vitro
study
molecular
cellular
mechanisms
of
create
models
disease.
However,
available
PSC
mouse
exhibit
low
overall
efficiencies
generation,
produce
heterogeneous
off-target
populations,
rely
upon
undefined
media
components,
thus
limiting
their
reproducibility,
scalability,
widespread
application
as
an
experimental
platform
for
biology.
To
address
these
important
limitations,
we
developed
efficient
reproducible
protocol
faithfully
the
stepwise
differentiation
PSCs
(epiblast
cells)
into
unspecialized,
proliferative
TRMs
through
pro-definitive
hematopoietic
program
under
defined
conditions.
These
immature
can
stably
integrate
developing
neural
organoids
acquire
features
microglia.
In
addition,
engraft
lung
niche
vivo
adopt
alveolar
macrophage
characteristics.
This
new
modeling
represents
a
powerful
model
system
studying
function
dysfunction
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 116925 - 116925
Опубликована: Июнь 15, 2024
Macrophages
are
central
to
the
immune
system
and
found
in
nearly
all
tissues.
Recently,
development
of
therapies
based
on
macrophages
has
attracted
significant
interest.
These
utilize
macrophages'
key
roles
immunity,
their
ability
navigate
biological
barriers,
tendency
accumulate
tumors.
This
review
explores
advancement
macrophage-based
treatments.
We
discuss
bioengineering
for
improved
anti-tumor
effects,
use
CAR
macrophage
therapy
targeting
cancer
cells,
as
vehicles
therapeutic
delivery.
Additionally,
we
examine
engineered
products,
like
extracellular
vesicles
membrane-coated
nanoparticles,
potential
precise
less
toxic
tumor
therapy.
Challenges
moving
these
from
research
clinical
practice
also
highlighted.
The
aim
is
succinctly
summarize
current
status,
challenges,
future
directions
