Decoding human chemical reprogramming: mechanisms and principles

Trends in Biochemical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Greasing the machinery toward maturation of stem cell-derived β cells

Cell stem cell, Год журнала: 2024, Номер 31(6), С. 793 - 794

Опубликована: Июнь 1, 2024

Язык: Английский

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Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 29, 2024

ABSTRACT Pluripotent stem cell (SC)-derived islets offer hope as a renewable source for β replacement type 1 diabetes (T1D), yet functional and metabolic immaturity may limit their long-term therapeutic potential. Here, we show that limitations in mitochondrial transcriptional programming impede the formation maturation of SC-derived (SC-β) cells. Utilizing transcriptomic profiling, assessments chromatin accessibility, phenotyping, lipidomics analyses, observed SC-β cells exhibit reduced oxidative fatty acid metabolism compared to primary human are related key networks. Surprisingly, found reductions glucose- stimulated respiration SC-islets were not associated with alterations mass, structure, or genome integrity. In contrast, limited expression targets PPARIZ PPARγ, which regulate programming, whose functions differentiation unknown. Importantly, treatment WY14643, potent agonist, induced targets, improved insulin secretion, increased both vitro following transplantation. Thus, promotes be promising target improve efforts T1D.

Язык: Английский

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cProtective Effects and Bioinformatic Analysis of Narciclasine on Vascular Aging via Cross-talk between Inflammation and Metabolism through Inhibiting Skeletal Muscle-specific Ceramide Synthase 1

Mechanisms of Ageing and Development, Год журнала: 2024, Номер unknown, С. 112021 - 112021

Опубликована: Дек. 1, 2024

Язык: Английский

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Insulin-producing cells derived from expandable stem cell-derived endoderm are effective for the treatment of type 2 diabetes

Annals of Translational Medicine, Год журнала: 2024, Номер 12(6), С. 121 - 121

Опубликована: Дек. 1, 2024

Язык: Английский

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