Cancer Letters,
Год журнала:
2024,
Номер
unknown, С. 217391 - 217391
Опубликована: Дек. 1, 2024
Circadian
rhythm,
regulated
by
a
time
keeping
system
termed
as
the
circadian
clock,
is
important
for
many
biological
processes
in
eukaryotes.
Disordered
rhythm
implicated
different
human
diseases,
including
cardiovascular
disease,
neurologic
metabolic
disorders,
and
cancer.
The
stem
like-cancer
cells
(or
cancer
cells,
CSCs)
are
proposed
to
stand
at
top
of
heterogeneous
hierarchy
solid
tumors,
which
responsible
tumor
initiation,
development,
therapy
resistance
metastasis.
Emerging
evidence
has
shown
that
clock
genes
potentially
regulate
stemness
features
CSCs
several
malignant
systems,
leukemia,
glioblastoma,
breast
cancer,
colorectal
prostate
chronotherapies
targeting
therefore
therapeutic
potentials
treating
malignancies.
In
this
review,
we
have
summarized
our
current
knowledge
gene
regulation
normal
stem/progenitor
cells.
Moreover,
provided
linking
dysregulations
development.
Importantly,
listed
potential
mechanisms
underlying
CSCs.
Finally,
offered
attempts
chronotherapy
Elucidating
molecular
will
provide
us
novel
direction
development
therapeutics
target
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Май 29, 2025
Circadian
rhythms
orchestrate
nearly
every
aspect
of
human
physiology
through
a
hierarchical
network
clocks.
While
the
suprachiasmatic
nucleus
(SCN)
serves
as
central
pacemaker,
peripheral
clocks
within
brain,
heart,
liver,
gut,
pancreas,
adipose
tissue,
adrenal
glands,
lungs,
and
skeletal
muscle
independently
regulate
organ-specific
functions.
These
autonomous
oscillators,
governed
by
transcriptional–translational
feedback
loops
core
clock
genes,
align
with
environmental
physiological
zeitgebers
such
light,
feeding,
temperature,
hormones.
Disruption
this
temporal
organization—through
shift
work,
genetic
alterations,
or
lifestyle
factors—drives
systemic
misalignment,
contributing
to
metabolic
disease,
cardiovascular
dysfunction,
neurodegeneration,
cancer,
immune
imbalance.
This
review
explores
molecular
mechanisms
roles
across
organ
systems,
emphasizing
their
interplay
SCN
.
We
also
highlight
emerging
chronotherapeutic
strategies
that
exploit
circadian
biology
optimize
treatment
outcomes.
Understanding
inter-organ
communication
is
key
unlocking
personalized
interventions
restoring
rhythmicity
for
health.
Biology,
Год журнала:
2024,
Номер
13(12), С. 1031 - 1031
Опубликована: Дек. 10, 2024
Background:
Circadian
rhythms
are
driven
by
the
biological
clock,
an
endogenous
oscillator
that
generates
approximately
24
h
cycles
in
mammals.
The
circadian
regulation
of
lipid
metabolism
plays
a
crucial
role
overall
metabolic
health.
An
analysis
correlation
between
skin’s
physiological
parameters
and
skin
lipids
can
provide
better
insight
into
rhythmic
changes
condition.
Objectives:
aim
was
to
reveal
how
surface
(SSLs)
participate
importance
oscillation
facial
molecules
maintaining
epidermal
homeostasis.
Methods:
Changes
SSLs
were
assessed
using
UPLC-QTOF-MS.
quantified
non-invasive
instruments.
Multivariate
data
employed
evaluate
differences.
Results:
Both
exhibited
certain
variation
patterns.
Four
major
classes
(fatty
acids,
glycerophospholipids,
prenol
lipids,
saccharolipids)
trends,
with
seven
subclasses
contributing
most
significantly
patterns
observed.
Among
assessed,
sebum
secretion,
transepidermal
water
loss,
moisture
measurement
value,
temperature
sinusoidal
rhythms.
Further
revealed
significant
correlations
fatty
acids
saccharolipids
values,
glycerolipids
pH
value.
In
addition,
closely
associated
barrier
such
as
unsaturated
ceramide
chain
lengths
correlated
values.
Conclusions:
Through
analysis,
study
elucidates
influence
diurnal
fluctuations
on
function.
These
findings
hold
implications
for
understanding
impairment
rhythm
disruptions.
Cancer Letters,
Год журнала:
2024,
Номер
unknown, С. 217391 - 217391
Опубликована: Дек. 1, 2024
Circadian
rhythm,
regulated
by
a
time
keeping
system
termed
as
the
circadian
clock,
is
important
for
many
biological
processes
in
eukaryotes.
Disordered
rhythm
implicated
different
human
diseases,
including
cardiovascular
disease,
neurologic
metabolic
disorders,
and
cancer.
The
stem
like-cancer
cells
(or
cancer
cells,
CSCs)
are
proposed
to
stand
at
top
of
heterogeneous
hierarchy
solid
tumors,
which
responsible
tumor
initiation,
development,
therapy
resistance
metastasis.
Emerging
evidence
has
shown
that
clock
genes
potentially
regulate
stemness
features
CSCs
several
malignant
systems,
leukemia,
glioblastoma,
breast
cancer,
colorectal
prostate
chronotherapies
targeting
therefore
therapeutic
potentials
treating
malignancies.
In
this
review,
we
have
summarized
our
current
knowledge
gene
regulation
normal
stem/progenitor
cells.
Moreover,
provided
linking
dysregulations
development.
Importantly,
listed
potential
mechanisms
underlying
CSCs.
Finally,
offered
attempts
chronotherapy
Elucidating
molecular
will
provide
us
novel
direction
development
therapeutics
target
