The impaired response of nasal epithelial cells to microplastic stimulation in asthma and COPD
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 4, 2025
Microplastic
particles
from
the
air
are
inhaled
and
accumulate
in
lungs,
potentially
causing
immunological
reactions
airway
tissue
injury.
This
study
aimed
to
evaluate
biological
effects
of
polyamide
fibres
on
nasal
epithelium
co-cultivated
with
macrophages
control,
asthma,
COPD
groups.
Nasal
epithelial
cells
alone
or
co-culture
monocyte-derived
were
exposed
for
48
h.
We
identified
8
differentially
expressed
genes
(DEGs)
controls,
309
DEGs
asthma
(including
ANKRD36C,
BCL2L15,
FCGBP,
IL-19),
22
(e.g.,
IL-19,
CAPN14,
PGBD5,
PTPRH),
particularly
epithelial/moMφ
co-cultures.
exposure
induced
inflammatory
cytokine
secretion
only
IL-8
production
controls
(epithelial/
moMφs
co-culture)
asthmatic
(monoculture)
contrast
PM2.5,
which
was
a
strong
inducer.
Gene
Ontology
analysis
revealed
that
microplastic
affected
sterol
cholesterol
biosynthesis,
secondary
alcohol
metabolism,
acetyl-CoA
metabolism
cell
motility,
chemokine
signaling,
leukocyte
migration,
chemotaxis
COPD.
stimulation
altered
response
obstructive
lung
diseases
differently
than
linking
Th2
inflammation,
stress
modulation,
carcinogenesis.
Asthmatic
more
susceptible
damage
fibre
exposure.
Язык: Английский
Unlocking lung regeneration: insights into progenitor cell dynamics and metabolic control
Cell Regeneration,
Год журнала:
2024,
Номер
13(1)
Опубликована: Дек. 16, 2024
Abstract
Regenerative
responses
are
particularly
important
in
the
lungs,
which
critical
for
gas
exchange
and
frequently
challenged
by
environmental
insults.
The
lung
progenitor
cells
play
a
central
role
regeneration
response,
their
dysfunction
is
associated
with
various
diseases.
Understanding
mechanisms
regulating
cell
function
essential
developing
new
therapeutic
approaches
to
promote
regeneration.
This
review
summarizes
recent
advancements
field
of
regeneration,
focusing
on
metabolic
control
function.
We
discuss
lineage
plasticity
cell–cell
signaling
under
different
physiological
conditions.
Additionally,
we
highlight
connection
between
diseases,
emphasizing
need
develop
strategies
regenerative
medicine
improve
capacity.
Язык: Английский