Bioengineering innovations for neural organoids with enhanced fidelity and function

Cell stem cell, Год журнала: 2025, Номер 32(5), С. 689 - 709

Опубликована: Май 1, 2025

Язык: Английский

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Engineering blood–brain barrier microphysiological systems to model Alzheimer's disease monocyte penetration and infiltration

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We report the development of engineered human stem cell-derived blood-brain barrier microphysiological systems for modeling neuroinflammation in Alzheimers' disease.

Язык: Английский

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Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 24, 2025

Abstract The complexity and precision of the human nervous system have posed significant challenges for researchers seeking suitable models to elucidate refractory neural disorders. Traditional approaches, including monolayer cell cultures animal models, often fail replicate intricacies tissue. advent organoid technology derived from stem cells has addressed many these limitations, providing highly representative platforms studying structure function embryonic brain spinal cord. Researchers induced organoids with regional characteristics by mimicking morphogen gradients in development. Recent advancements demonstrated utility disease modeling, offering insights into pathophysiology various disorders, as well field regeneration. Developmental defects due lack microglia or vascular systems are addressed. In addition induction methods, microfluidics is used simulate dynamic physiological environment; bio‐manufacturing technologies employed regulate physical signaling shape complex organs. These further expand construction strategies application scope organoids. With emergence new material paradigms advances AI, possibilities realm witnessed.

Язык: Английский

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Mind over scaffold: Vascular network-inspired scaffolds for functionally mature neural organoids

Опубликована: Май 1, 2025

Язык: Английский

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Engineering Spinal Cord and Peripheral Nerve Organoids: Strategies for Construction and Potential Applications for Regenerative Medicine in Neurotrauma

Engineering, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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