
Engineering, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Engineering, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Cell stem cell, Год журнала: 2025, Номер 32(5), С. 689 - 709
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
We report the development of engineered human stem cell-derived blood-brain barrier microphysiological systems for modeling neuroinflammation in Alzheimers' disease.
Язык: Английский
Процитировано
0Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Май 24, 2025
Abstract The complexity and precision of the human nervous system have posed significant challenges for researchers seeking suitable models to elucidate refractory neural disorders. Traditional approaches, including monolayer cell cultures animal models, often fail replicate intricacies tissue. advent organoid technology derived from stem cells has addressed many these limitations, providing highly representative platforms studying structure function embryonic brain spinal cord. Researchers induced organoids with regional characteristics by mimicking morphogen gradients in development. Recent advancements demonstrated utility disease modeling, offering insights into pathophysiology various disorders, as well field regeneration. Developmental defects due lack microglia or vascular systems are addressed. In addition induction methods, microfluidics is used simulate dynamic physiological environment; bio‐manufacturing technologies employed regulate physical signaling shape complex organs. These further expand construction strategies application scope organoids. With emergence new material paradigms advances AI, possibilities realm witnessed.
Язык: Английский
Процитировано
0Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Engineering, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0