Micro-Physiological System of Human Lung: The Current Status and Application to Drug Discovery

Drug Metabolism and Pharmacokinetics, Год журнала: 2025, Номер 60, С. 101050 - 101050

Опубликована: Янв. 9, 2025

Various attempts have been made to elucidate the mechanisms of human lung development, its physiological functions, and diseases, in hope new drug discovery. Recent technological advancements experimental animals, cell culture, gene editing, analytical methods provided insights therapeutic strategies. However, results obtained from animal experiments are often inconsistent with those data because reproducibility issues caused by structural differences between mice humans. In addition, it is not possible accurately reproduce internal environment structure using conventional two-dimensional (2D) or three-dimensional (3D) culture methods. As a result, micro-physiological system (MPS) technology, such as "lung-on-a-chip" that can cells state close body developed, applications disease models, toxicological studies, discovery accelerated worldwide. Here, we focus on mimetics lung, including review their recent progress, achievements challenges. Finally, discuss role these chips for refractory diseases.

Язык: Английский

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Cell therapy: A beacon of hope in the battle against pulmonary fibrosis

The FASEB Journal, Год журнала: 2025, Номер 39(2)

Опубликована: Янв. 28, 2025

Abstract Pulmonary fibrosis (PF) is a chronic and progressive interstitial lung disease characterized by abnormal activation of myofibroblasts pathological remodeling the extracellular matrix, with poor prognosis limited treatment options. Lung transplantation currently only approach that can extend life expectancy patients; however, its applicability severely restricted due to donor shortages patient‐specific limitations. Therefore, search for novel therapeutic strategies imperative. In recent years, stem cells have shown great promise in field regenerative medicine their self‐renewal capacity multidirectional differentiation potential, growing body literature supports efficacy cell therapy PF treatment. This paper systematically summarizes research progress various types PF. Furthermore, it discusses primary methods clinical outcomes PF, based on both preclinical data. Finally, current challenges key factors consider are objectively analyzed, future directions improving this proposed, providing new insights references patients.

Язык: Английский

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Unlocking lung regeneration: insights into progenitor cell dynamics and metabolic control

Cell Regeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Дек. 16, 2024

Abstract Regenerative responses are particularly important in the lungs, which critical for gas exchange and frequently challenged by environmental insults. The lung progenitor cells play a central role regeneration response, their dysfunction is associated with various diseases. Understanding mechanisms regulating cell function essential developing new therapeutic approaches to promote regeneration. This review summarizes recent advancements field of regeneration, focusing on metabolic control function. We discuss lineage plasticity cell–cell signaling under different physiological conditions. Additionally, we highlight connection between diseases, emphasizing need develop strategies regenerative medicine improve capacity.

Язык: Английский

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Hippo-TOR Signaling Crosstalks Underpin Microtubule Acetylation-linked Carcinogenesis inDrosophilaSquamous Epithelia

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 9, 2024

ABSTRACT Flattened squamous epithelial tissues undergo extensive cytoskeletal remodeling and display perpetual nuclear signaling of the Hippo transcription cofactor, YAP/TAZ, in mammals Yki Drosophila . Loss YAP humans or causes cell carcinoma (SCC), but only select types. Here, we reveal a mechanism Yki-loss induced SCC lumen-lining epithelium male accessory gland (MAG) loss MAG triggers TOR signaling-mediated microtubule hyperacetylation, which causally underpins its SCC. By contrast, oocyte-enveloping follicular neither activates nor induce hyperacetylation. Analysis available single-cell transcriptomic data further revealed characteristic type-specific signatures signaling. Thus, disparate epigenetic landscapes distinct mechanosensory cues likely prefigures their susceptibility to Yki-loss, with epithelia being oncogenically more susceptible.

Язык: Английский

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Multidisciplinary approaches in electronic nicotine delivery systems pulmonary toxicology: emergence of living and non-living bioinspired engineered systems

Communications Engineering, Год журнала: 2024, Номер 3(1)

Опубликована: Сен. 3, 2024

Abstract Technology-based platforms offer crucial support for regulatory agencies in overseeing tobacco products to enhance public health protection. The use of electronic nicotine delivery systems (ENDS), such as cigarettes, has surged exponentially over the past decade. However, understanding impact ENDS on lung remains incomplete due scarcity physiologically relevant technologies evaluating their toxicity. This review examines societal and impacts ENDS, prevalent preclinical approaches pulmonary space, application emerging Organ-on-Chip bioinspired robotics assessing respiratory It highlights challenges inhalation toxicology value multidisciplinary bioengineering generating reliable, human-relevant data at an accelerated pace.

Язык: Английский

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Alveolar Epithelium in Lung Toxicology

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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