Microglia‐Derived Vitamin D Binding Protein Mediates Synaptic Damage and Induces Depression by Binding to the Neuronal Receptor Megalin

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract Vitamin D binding protein (VDBP) is a potential biomarker of major depressive disorder (MDD). This study demonstrates for the first time that VDBP highly expressed in core emotion‐related brain regions mice susceptible to chronic unpredictable mild stress (CUMS). Specifically, overexpression microglia (MG)‐derived prelimbic leads depression‐like behavior and aggravates CUMS‐induced phenotypes mice, whereas conditional knockout MG‐derived can reverse both neuronal damage behaviors. Mechanistically, with receptor megalin mediates downstream SRC signaling pathway, leading synaptic These events may be caused by biased activation inhibitory neurons excitatory–inhibitory imbalance. Importantly, this has effectively identified as pivotal mediator interplay between via its interaction intricate impacts on functions, thus offering promising therapeutic target MDD.

Язык: Английский

Vitamin D and Endometriosis: Is There a Mechanistic Link?

Cell Biochemistry and Function, Год журнала: 2024, Номер 43(1)

Опубликована: Дек. 31, 2024

Endometriosis is a prevalent chronic gynaecological disorder, but its cause still unclear, and both genetic environmental factors may contribute disease aetiology. Prominent amongst the latter vitamin D which can be obtained either by action of sunlight on skin or from dietary sources. Serum levels main circulating form D, 25-hydroxvitamin (25(OH)D), have been reported to inversely correlated with endometriosis, suggesting that D-deficiency risk factor for disease. Crucially, active 1,25-dihydroxyvitamin (1,25(OH)

Язык: Английский