Endoscopic Delivery of a Double-Umbrella-Shaped Hydrogel Occluder with Instant Mechanical Interlock and Robust Wet Adhesion for Gastric Perforation Repair DOI
Haiyang Li, Ningli Chai, Yanyu Yang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Achieving robust adhesion of bioadhesives on wet tissues to block gastric perforation remains a challenge due the gradually deteriorated adhesive-tissue interactions by interfacial acidity and multienzyme fluids, thus accompanying failure shedding life-threatening risks. Here, we report biocompatible double-umbrella-shaped endoscopy-deliverable hydrogel occluder (EHO) made caffeic acid (CA)-grafted chitosan (CS) polyacrylamide (PAM) molding technique, which is capable customizable, rapid, robust, long-term sealing large perforations. In addition physiochemical (e.g., H-bonding, chelation) between polymers, efficient also integrates advantages fast mechanical interlocking in space gradual self-expansion over time tolerant acidic mechanically dynamic environments. The EHO exhibits favorable biodegradability reducible disulfide cross-linkers remarkable protective barrier functions impede infiltration digestive pepsin into wound. To validate EHO's therapeutic efficacy, further demonstrate vivo via endoscopic delivery porcine stomach monitor healing process with improved retention endogenous growth factors. Besides, views simple fabrication using biodegradable can be facilely tailored various topologies according application scenarios surgical minimally invasive delivery, offering promising alternative for clinical repair gastrointestinal perforations other organs.

Язык: Английский

3D-Printed Metal Organic Frameworks-Based Supramolecular Hydrogel as Biological Materials DOI Creative Commons
Moses Kumi, Bridget Kpomah, Onome Ejeromedoghene

и другие.

Supramolecular Materials, Год журнала: 2025, Номер unknown, С. 100100 - 100100

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Development of hyaluronic acid-based hydrogels for chronic diabetic wound healing: A review DOI
Wenhao Zhang, Yang Liu,

Ling Zhang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142273 - 142273

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Endoscopic Delivery of a Double-Umbrella-Shaped Hydrogel Occluder with Instant Mechanical Interlock and Robust Wet Adhesion for Gastric Perforation Repair DOI
Haiyang Li, Ningli Chai, Yanyu Yang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Achieving robust adhesion of bioadhesives on wet tissues to block gastric perforation remains a challenge due the gradually deteriorated adhesive-tissue interactions by interfacial acidity and multienzyme fluids, thus accompanying failure shedding life-threatening risks. Here, we report biocompatible double-umbrella-shaped endoscopy-deliverable hydrogel occluder (EHO) made caffeic acid (CA)-grafted chitosan (CS) polyacrylamide (PAM) molding technique, which is capable customizable, rapid, robust, long-term sealing large perforations. In addition physiochemical (e.g., H-bonding, chelation) between polymers, efficient also integrates advantages fast mechanical interlocking in space gradual self-expansion over time tolerant acidic mechanically dynamic environments. The EHO exhibits favorable biodegradability reducible disulfide cross-linkers remarkable protective barrier functions impede infiltration digestive pepsin into wound. To validate EHO's therapeutic efficacy, further demonstrate vivo via endoscopic delivery porcine stomach monitor healing process with improved retention endogenous growth factors. Besides, views simple fabrication using biodegradable can be facilely tailored various topologies according application scenarios surgical minimally invasive delivery, offering promising alternative for clinical repair gastrointestinal perforations other organs.

Язык: Английский

Процитировано

0