Renewable Polymers in Biomedical Applications: From the Bench to the Market DOI Open Access
Rauany Cristina Lopes Francisco, Tamires de Souza Nossa, Wilton R. Lustri

и другие.

JOURNAL OF RENEWABLE MATERIALS, Год журнала: 2024, Номер 12(4), С. 643 - 666

Опубликована: Янв. 1, 2024

Polymers from renewable resources have been used for a long time in biomedical applications and found an irreplaceable role some of them.Their uses increasing because their attractive properties, contributing to the improvement life quality, mainly drug release systems regenerative medicine.Formulations using natural polymer, nano microscale particles preparation, composites, blends chemical modification strategies improve properties clinical application.Although many studies carried out with these polymers, way reach market is only very few them become commercially available.Vegetable cellulose, bacterial chitosan, poly(lactic acid) starch can be among most studied polymers biological applications, several derivatives already established market, others potential such.In this scenario work aims describe routes bench perspectives future developments.

Язык: Английский

Cu-MOF loaded chitosan based freeze-dried highly porous dressings with anti-biofilm and pro-angiogenic activities accelerated Pseudomonas aeruginosa infected wounds healing in rats DOI

Saima Zulfiqar,

Shahzad Sharif, Muhammad Nawaz

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 271, С. 132443 - 132443

Опубликована: Май 16, 2024

Язык: Английский

Процитировано

7

Synthesis and characterisation of magnesium-wrapped hydroxyapatite nanomaterials for biomedical applications DOI

S. Sebastiammal,

Arul Sigamani Lesly Fathima,

Khalid A. Al‐Ghanim

и другие.

Surfaces and Interfaces, Год журнала: 2023, Номер 44, С. 103779 - 103779

Опубликована: Дек. 19, 2023

Язык: Английский

Процитировано

14

Emerging nanomaterials for novel wound dressings: From metallic nanoparticles and MXene nanosheets to metal-organic frameworks DOI Creative Commons

Gholamreza Faghani,

Amir Azarniya

Heliyon, Год журнала: 2024, Номер 10(21), С. e39611 - e39611

Опубликована: Окт. 22, 2024

The growing need for developing reliable and efficient wound dressings has led to recent progress in designing novel materials formulations different kinds of wounds caused by traumas, burns, surgeries, diabetes. In cases extreme urgency, accelerating recovery is high importance prevent persistent infection biofilm formation. application nanotechnology this domain resulted the creation distinct nanoplatforms highly advanced wound-healing therapeutic approaches. Recently developed nanomaterials have been used as antibacterial agents or drug carriers control infection. present review, authors aim review recently published research on effects incorporating emerging into investigate their roles healing process. It was determined that metallic nanoparticles (NPs) exhibit antimicrobial regenerative properties, metal oxide NPs regulate inflammation promote tissue regeneration, MXene enhance cell adhesion proliferation, while metal-organic frameworks (MOFs) offer controlled delivery capabilities. Further required fully understand mechanisms optimize applications these healing.

Язык: Английский

Процитировано

6

Adhesive Antibacterial Moisturizing Nanostructured Skin Patch for Sustainable Development of Atopic Dermatitis Treatment in Humans DOI
Alicja Kosik‐Kozioł, Paweł Nakielski, Daniel Rybak

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(25), С. 32128 - 32146

Опубликована: Июнь 14, 2024

Atopic dermatitis (AD) is a chronic inflammatory skin disease with complex etiology that lacks effective treatment. The therapeutic goals include alleviating symptoms, such as moisturizing and applying antibacterial anti-inflammatory medications. Hence, there an urgent need to develop patch effectively alleviates most of the AD symptoms. In this study, we employed "green" cross-linking approach poly(vinyl alcohol) (PVA) using glycerol, combined it polyacrylonitrile (PAN) fabricate core–shell (CS) nanofibers through electrospinning. Our designed structure offers multiple benefits core ensures controlled drug release increases strength patch, while shell provides moisturization exudate absorption. efficient PVA method facilitates inclusion sensitive molecules fermented oils. vitro studies demonstrate patches' exceptional biocompatibility efficacy in minimizing cell ingrowth into CS containing argan oil, property highly desirable for easy removal patch. Histological examinations conducted on ex vivo model showed nonirritant properties developed patches. Furthermore, eradication Staphylococcus aureus bacteria confirms potential use loaded oil or norfloxacin, separately, infected wounds. application patients, including one AD, demonstrated ideal effect. This innovative shows significant promise enhancing life quality sufferers by improving hydration avoiding infections.

Язык: Английский

Процитировано

5

Conductive Bacterial Nanocellulose-Polypyrrole Patches Promote Cardiomyocyte Differentiation DOI Creative Commons
Sumithra Yasaswini Srinivasan,

Marina Cler,

Osnat Zapata‐Arteaga

и другие.

ACS Applied Bio Materials, Год журнала: 2023, Номер 6(7), С. 2860 - 2874

Опубликована: Июнь 21, 2023

The low endogenous regenerative capacity of the heart, added to prevalence cardiovascular diseases, triggered advent cardiac tissue engineering in last decades. myocardial niche plays a critical role directing function and fate cardiomyocytes; therefore, biomimetic scaffold holds excellent promise. We produced an electroconductive patch bacterial nanocellulose (BC) with polypyrrole nanoparticles (Ppy NPs) mimic natural microenvironment. BC offers 3D interconnected fiber structure high flexibility, which is ideal for hosting Ppy nanoparticles. BC-Ppy composites were by decorating network fibers (65 ± 12 nm) conductive (83 8 nm). NPs effectively augment conductivity, surface roughness, thickness despite reducing scaffolds' transparency. flexible (up 10 mM Ppy), maintained their intricate extracellular matrix-like mesh all concentrations tested, displayed electrical conductivities range native tissue. Furthermore, these materials exhibit tensile strength, wettability values appropriate final use as patches. In vitro experiments fibroblasts H9c2 cells confirmed exceptional biocompatibility composites. scaffolds improved cell viability attachment, promoting desirable cardiomyoblast morphology. Biochemical analyses revealed that showed different cardiomyocyte phenotypes distinct levels maturity depending on amount substrate used. Specifically, employment drives partial differentiation toward cardiomyocyte-like phenotype. increase expression functional markers cells, indicative higher efficiency, not observed plain BC. Our results highlight remarkable potential therapies.

Язык: Английский

Процитировано

12

A comprehensive study on a novel chitosan/Ag-MOFs nanocomposite coatings for bone implants: Physico-chemical, biological and electrochemical properties DOI
Shahab Ahmadi Seyedkhani, Seyed Mohsen Dehnavi, Mahdi Barjasteh

и другие.

Materials Chemistry and Physics, Год журнала: 2023, Номер 308, С. 128268 - 128268

Опубликована: Июль 31, 2023

Язык: Английский

Процитировано

12

Sustainable celloMOF cargoes for regenerative medicine and drug delivery therapies: A review DOI
Farhad Esmailzadeh, Reza Taheri‐Ledari,

Amir Kashtiaray

и другие.

Industrial Crops and Products, Год журнала: 2024, Номер 212, С. 118293 - 118293

Опубликована: Март 7, 2024

Язык: Английский

Процитировано

4

Impedance Spectroscopy and Antimicrobial Activity in ZnO–Cellulose/Chitosan@Cu2+ Wavy‐Like Nanocomposites Formed via Semi‐Dissolved Chitosan Templating DOI

Amel Mohamed Abouelnaga

Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(3)

Опубликована: Март 1, 2025

ABSTRACT In this study, an advanced approach to synthesizing wavy ZnO–cellulose/chitosan@Cu 2+ nanocomposites with improved functionality and conductivity was semi‐dissolving chitosan as a dual‐functionality template. The template method uses form semi‐porous structures ethylene glycol the solvent crystallization agent for hybrid nanostructures. surface morphology, stability, conductive nano‐nanostructures significantly improve microstructural, electrical, antimicrobial properties of Cu‐doped ZnO–cellulose/chitosan formed composite morphology thermal are characterized by thermogravimetric analysis (TGA) field emission scanning electron microscope (SEM–EDX). revealed that nanostructures exhibited steady‐state plateau at low frequencies, which represents DC conductivity, while transferred frequency‐dependent increase higher frequencies due hopping conduction mechanism, Ac conductivity. impedance spectroscopy represented Cole–Cole indicated non‐Debye relaxation processes. equivalent circuit parameters estimated different samples showed segmental capacitance (C1) resistance (R1) values ranging from 4.5665 × 10 −11 F 2.3882 −10 4.9 6 Ω 5.244 5 Ω, Cu concentration increased zero (A0) 4 mol%(A2), respectively. activity using Well diffusion technique. demonstrated inhibition zone diameters 19 31 mm against various microorganisms, including 30 Aspergillus fumigatus 28 Escherichia coli A3 (6 mol% ). These findings suggest can be utilized in biomedical fields such wound dressings, environmental conservation, food packaging, coatings.

Язык: Английский

Процитировано

0

Conductive Polymers and Hydrogels for Brain-Computer Interfaces DOI
Shahab Ahmadi Seyedkhani, Azam Iraji zad, Raheleh Mohammadpour

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Advanced development of smart stimulus-responsive cellulose-based composites through polymer science and nanoscale engineering: Preparation approaches and applications DOI
Jiaqi Lang, Qi Liu, Ming‐Guo Ma

и другие.

Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123611 - 123611

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0