Rapid enrichment and SERS differentiation of various bacteria in skin interstitial fluid by 4-MPBA-AuNPs-functionalized hydrogel microneedles DOI Creative Commons
Ying Yang,

Xingyu Wang,

Yexin Hu

и другие.

Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 15(3), С. 101152 - 101152

Опубликована: Ноя. 20, 2024

Bacterial infection is a major threat to global public health, and can cause serious diseases such as bacterial skin foodborne diseases. It essential develop new method rapidly diagnose clinical multiple infections monitor food microbial contamination in production sites real-time. In this work, we developed 4-mercaptophenylboronic acid gold nanoparticles (4-MPBA-AuNPs)-functionalized hydrogel microneedle (MPBA-H-MN) for bacteria detection interstitial fluid. MPBA-H-MN could conveniently capture enrich variety of within 5 min. Surface enhanced Raman spectroscopy (SERS) was then performed combined with machine learning technology distinguish identify bacteria. Overall, the efficiency exceeded 50%. concentration range 1 × 107 1010 colony-forming units/mL (CFU/mL), corresponding SERS intensity showed certain linear relationship concentration. Using random forest (RF)-based learning, were effectively distinguished an accuracy 97.87%. addition, harmless disposal used MNs by photothermal ablation convenient, environmentally friendly, inexpensive. This technique provided potential rapid real-time diagnosis monitoring sites.

Язык: Английский

Innovative Nanozyme-Based Detection Methods for Biomarkers in Interstitial Fluid DOI

Jiuhong Zhao,

Junjie Tian, Xiaoyu Zhang

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 118248 - 118248

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1

Glucose detection: In-situ colorimetric analysis with double-layer hydrogel microneedle patch based on polyvinyl alcohol and carboxymethyl chitosan DOI

Yannan Yin,

Xiaodan Li,

Meng Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134408 - 134408

Опубликована: Авг. 2, 2024

Язык: Английский

Процитировано

9

Recent progress in the 3D printing of microneedle patches for biomedical applications DOI
Huan Liu,

Aminov Nail,

Decheng Meng

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124995 - 124995

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

7

Staggered Design of UV–Curable Polymer Microneedle Arrays with Increased Vertical Action Space DOI Open Access
Baoling Jia,

Tiandong Xia,

Yangtao Xu

и другие.

Polymers, Год журнала: 2025, Номер 17(1), С. 104 - 104

Опубликована: Янв. 2, 2025

Recent studies have identified microneedle (MN) arrays as promising alternatives for transdermal drug delivery. This study investigated the properties of novel staggered MN design featuring two distinct heights MNs. The were precisely fabricated via PμSL light-cured 3D printing technology. systematically evaluated their morphology, fracture force, skin penetration ability, mechanism, and delivery capability. results demonstrated that punctured incrementally, leveraging benefits deformation during puncture process. approach effectively reduced force needed, achieving a maximum reduction approximately 80.27% due to variations in height. Additionally, facilitated penetration, confirmed by rat hematoxylin-eosin (H&E) staining experiments. Compared with 3D-printed planar structures highly uniform arrays, exhibited enhanced hydrophilicity, evidenced contact angle from 93° 70°. Simulated release images both coated hollow MNs illustrated capabilities these across various layers, expanded effective area within vertical dimension layers. offers experimental theoretical foundations developing three–dimensional structural distributions, thereby facilitating advancements array

Язык: Английский

Процитировано

1

Interfacing hydrogel microneedle patch for diagnosis DOI

Mengyao Miao,

Qiaoli Wu,

Xingwu Zhou

и другие.

Surfaces and Interfaces, Год журнала: 2024, Номер unknown, С. 105474 - 105474

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

4

3D-printed microneedles for sensing applications: emerging topics and future trends DOI Creative Commons
Kelcilene B. R. Teodoro, Tamires S. Pereira, Ana Laura M.M. Alves

и другие.

Advanced Sensor and Energy Materials, Год журнала: 2025, Номер unknown, С. 100139 - 100139

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

From fabrication to function: Mechanical insights into GelMA microneedle arrays DOI Creative Commons

Moloud Amini Baghbadorani,

Masoumeh Zargar, Asghar Eskandarinia

и другие.

Smart Materials in Manufacturing, Год журнала: 2025, Номер 3, С. 100083 - 100083

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Enhancing vascular implants with heparin-polylysine-copper nanozyme coating for synergistic anticoagulation and antirestenotic activity DOI
Zheng Zeng, Tao Liu, Pei Zeng

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143048 - 143048

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery DOI Creative Commons
Hui Li,

Fengzhen Meng,

Chengwei Hu

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Abstract The microneedle, a minimally invasive transdermal system, provides convenient and painless method for drug delivery. Among the various types of microneedles, hydrogel‐forming microneedles (HFMs) demonstrate distinct advantages in terms high‐dose loading biocompatibility. However, HFMs usually require drying to obtain sufficient puncture strength, which may destroy activity increase storage costs. Herein, high‐strength HFM patch with pH‐responsiveness post‐drug long‐term release is developed based on acrylonitrile‐acrylic acid copolymer. dipole‐dipole hydrogen bonding interactions formed through gradient solvent replacement are evenly distributed within cross‐linked network, significantly enhancing mechanical properties hydrogel required epidermal penetration. prepared exhibits tensile strength 26 MPa Young's modulus 407 MPa. from this display single needle force 1.18 N. post‐loading mode conferred by pH responsiveness allows be encapsulated both tips substrate, acting as reservoir. Once applied skin, microneedle activated body fluids achieve release. Overall, improves hydrated state, making it promising delivery platform.

Язык: Английский

Процитировано

0

SERS-Based Microneedle Biosensor for In Situ and Sensitive Detection of Tyrosinase DOI Creative Commons

Zimeng Gu,

Di Zhao, Hongyan He

и другие.

Biosensors, Год журнала: 2024, Номер 14(4), С. 202 - 202

Опубликована: Апрель 19, 2024

Tyrosinase (TYR) emerges as a key enzyme that exerts regulatory influence on the synthesis of melanin, thereby assuming role critical biomarker for detection melanoma. Detecting authentic concentration TYR in skin remains primary challenge. Distinguished from ex vivo methods, this study introduces novel sensor platform integrates microneedle (MN) biosensor with surface-enhanced Raman spectroscopy (SERS) technology situ human skin. The utilized dopamine (DA)-functionalized gold nanoparticles (Au NPs) capturing substrate and 4-mercaptophenylboronic acid (4-MPBA)-modified silver (Ag acting SERS probe. Here, Au NPs were functionalized mercaptosuccinic (MSA) DA capture. In presence TYR, immobilized MN is preferentially oxidized to quinone (DQ), process results decreased density probes platform. was detected through variations signal intensity emitted by phenylboronic acid. system able evaluate concentrations within linear range 0.05 U/mL 200 showed robust anti-interference capabilities. proposed platform, integrating MN-based sensing, technology, responsiveness, holds significant importance diagnosing cutaneous

Язык: Английский

Процитировано

2