Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101060 - 101060
Опубликована: Апрель 1, 2025
Язык: Английский
Nano Biomedicine and Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2
Small, Год журнала: 2024, Номер 20(29)
Опубликована: Фев. 22, 2024
Parkinson's disease (PD) is currently the second most incurable central neurodegenerative resulting from various pathogenesis. As "energy factory" of cells, mitochondria play an extremely important role in supporting neuronal signal transmission and other physiological activities. Mitochondrial dysfunction can cause accelerate occurrence progression PD. How to effectively prevent suppress mitochondrial disorders a key strategy for treatment PD root. Therefore, emerging mitochondria-targeted therapy has attracted considerable interest. Herein, relationship between PD, causes results dysfunction, major strategies ameliorating treat are systematically reviewed. The study also prospects main challenges
Язык: Английский
Процитировано
8
ACS Omega, Год журнала: 2024, Номер 9(33), С. 35223 - 35242
Опубликована: Авг. 5, 2024
Neurodegenerative diseases, encompassing conditions such as Alzheimer's disease, Parkinson's multiple sclerosis, amyotrophic lateral prion and Huntington's present a growing health concern human life expectancy increases. Despite this, effective treatments to halt disease progression remain elusive due various factors, including challenges in drug delivery across physiological barriers like the blood-brain barrier patient compliance issues leading treatment discontinuation. In response, innovative approaches leveraging noninvasive techniques with higher are emerging promising alternatives. This Review aims synthesize current options encountered managing neurodegenerative while also exploring modalities. Specifically, strategies intranasal administration nanosized systems gaining prominence for their potential enhance efficacy adherence. Nanosized systems, liposomes, polymeric micelles, nanoparticles, evaluated within context of outstanding studies. The advantages disadvantages these discussed, providing insights into therapeutic limitations. Through this comprehensive examination, contributes ongoing discourse surrounding development diseases.
Язык: Английский
Процитировано
8
Asian Journal of Biochemistry Genetics and Molecular Biology, Год журнала: 2025, Номер 17(1), С. 32 - 41
Опубликована: Янв. 11, 2025
In recent years, herbal plants have been widely used in the treatment of neurodegenerative diseases. Centella asiatica (l.) urb is a significant medicinal plant renowned for its diverse ethnomedicinal applications. The present study evaluated biological activities neuroprotective effect C. asiatica. summary, was identified using DNA barcoding such as matK and rbcL genes. sequences obtained were then compared through similarity search NCBI GenBank database. Notably, extracts exhibited high acetylcholinesterase inhibitory activity. Furthermore, butanol extract demonstrated most neurotrophic effects preliminary cell-based screenings, particularly promoting neurite outgrowth C6 cells. These findings suggest that holds considerable promise potential candidate development pharmacological treatments
Язык: Английский
Процитировано
0
Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101060 - 101060
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0