Microbial cell factories for bioeconomy: From discovery to creation

BioDesign Research, Год журнала: 2024, Номер 6

Опубликована: Янв. 1, 2024

Microbial cell factories (MCFs) are extensively used to produce a wide array of bioproducts, such as bioenergy, biochemical, food, nutrients, and pharmaceuticals, have been regarded the "chips" biomanufacturing that will fuel emerging bioeconomy era. Biotechnology advances led screening, investigation, engineering an increasing number microorganisms diverse MCFs, which workhorses help develop bioeconomy. This review briefly summarizes progress strategies in development robust efficient MCFs for sustainable economic biomanufacturing. First, comprehensive understanding microbial chassis cells, including accurate genome sequences corresponding annotations; metabolic regulatory networks governing substances, energy, physiology, information; their similarity uniqueness compared with those other microorganisms, is needed. Moreover, application effective tools crucial both model nonmodel cells into identification characterization biological parts, well design, synthesis, assembly, editing, regulation genes, circuits, pathways. also highlights necessity integrating automation artificial intelligence (AI) biotechnology facilitate future customized synthetic expedite industrialization process

Язык: Английский

Paradigm of engineering recalcitrant non-model microorganism with dominant metabolic pathway as a biorefinery chassis

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Ноя. 30, 2024

Язык: Английский

Zymomonas mobilis: bringing an ancient human tool into the genomic era

Current Opinion in Biotechnology, Год журнала: 2025, Номер 92, С. 103257 - 103257

Опубликована: Янв. 21, 2025

Язык: Английский